Table of Contents

Articles

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  J-104,871, a Novel Farnesyltransferase Inhibitor, Blocks Ras Farnesylation In Vivo in a Farnesyl Pyrophosphate-Competitive Manner

  Mari Yonemoto, Toshihiko Satoh, Hiroharu Arakawa, Ikuko Suzuki-Takahashi, Yoshiaki Monden, Tsutomu Kodera, Kenji Tanaka, Tetsuya Aoyama, Yoshikazu Iwasawa, Toshio Kamei, Susumu Nishimura and Koji Tomimoto

  Molecular Pharmacology July 1998, 54 (1) 1-7; DOI: https://doi.org/10.1124/mol.54.1.1
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  Yeast Expressed Cytochrome P450 2D6 (CYP2D6) Exposed on the External Face of Plasma Membrane Is Functionally Competent

  Jacqueline Loeper, Bénédicte Louérat-Oriou, Catherine Duport and Denis Pompon

  Molecular Pharmacology July 1998, 54 (1) 8-13; DOI: https://doi.org/10.1124/mol.54.1.8
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  Protein Kinase C-Mediated Down-Regulation of β₁-Adrenergic Receptor Gene Expression in Rat C6 Glioma Cells

  Zhongwei Li, Vidita A. Vaidya, John D. Alvaro, Philip A. Iredale, Richard Hsu, Ginger Hoffman, Laura Fitzgerald, Patricia K. Curran, Curtis A. Machida, Peter H. Fishman and Ronald S. Duman

  Molecular Pharmacology July 1998, 54 (1) 14-21; DOI: https://doi.org/10.1124/mol.54.1.14
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  Isoquinolines as Antagonists of the P2X₇ Nucleotide Receptor: High Selectivity for the Human versus Rat Receptor Homologues

  Benjamin D. Humphreys, Caterina Virginio, Annmarie Surprenant, Janet Rice and George R. Dubyak

  Molecular Pharmacology July 1998, 54 (1) 22-32; DOI: https://doi.org/10.1124/mol.54.1.22
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  Photoaffinity Labeling of the Benzodiazepine Binding Site of α1β3γ2 γ-Aminobutyric Acid_A Receptors with Flunitrazepam Identifies a Subset of Ligands that Interact Directly with His102 of the α Subunit and Predicts Orientation of These within the Benzodiazepine Pharmacophore

  Ruth M. McKernan, Sophie Farrar, Ian Collins, Frances Emms, Ayodeji Asuni, Kathleen Quirk and Howard Broughton

  Molecular Pharmacology July 1998, 54 (1) 33-43; DOI: https://doi.org/10.1124/mol.54.1.33
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  Phosphorylation and Functional Desensitization of the α_2A-Adrenergic Receptor by Protein Kinase C

  Mei Liang, Margaret G. Eason, Elizabeth A. Jewell-Motz, Mark A. Williams, Cheryl T. Theiss, Gerald W. Dorn and Stephen B. Liggett

  Molecular Pharmacology July 1998, 54 (1) 44-49; DOI: https://doi.org/10.1124/mol.54.1.44
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  Protein-Linked DNA Strand Breaks Induced by NSC 314622, a Novel Noncamptothecin Topoisomerase I Poison

  Glenda Kohlhagen, Kenneth D. Paull, Mark Cushman, Pamela Nagafuji and Yves Pommier

  Molecular Pharmacology July 1998, 54 (1) 50-58; DOI: https://doi.org/10.1124/mol.54.1.50
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  A Crucial Role for the Mitogen-Activated Protein Kinase Pathway in Nicotinic Cholinergic Signaling to Secretory Protein Transcription in Pheochromocytoma Cells

  Kechun Tang, Hongjiang Wu, Sushil K. Mahata and Daniel T. O’Connor

  Molecular Pharmacology July 1998, 54 (1) 59-69; DOI: https://doi.org/10.1124/mol.54.1.59
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  Sphingosine Kinase Mediates Cyclic AMP Suppression of Apoptosis in Rat Periosteal Cells

  Mohamed Machwate, Sevgi B. Rodan, Gideon A. Rodan and Shun-Ichi Harada

  Molecular Pharmacology July 1998, 54 (1) 70-77; DOI: https://doi.org/10.1124/mol.54.1.70
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  Etoposide Targets Topoisomerase IIα and IIβ in Leukemic Cells: Isoform-Specific Cleavable Complexes Visualized and QuantifiedIn Situ by a Novel Immunofluorescence Technique

  E. Willmore, A. J. Frank, K. Padget, M. J. Tilby and C. A. Austin

  Molecular Pharmacology July 1998, 54 (1) 78-85; DOI: https://doi.org/10.1124/mol.54.1.78
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  Point Mutation in Intron Sequence Causes Altered Carboxyl-Terminal Structure in the Aryl Hydrocarbon Receptor of the Most 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Resistant Rat Strain

  Raimo Pohjanvirta, Judy M. Y. Wong, Wei Li, Patricia A. Harper, Jouko Tuomisto and Allan B. Okey

  Molecular Pharmacology July 1998, 54 (1) 86-93; DOI: https://doi.org/10.1124/mol.54.1.86
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  Effector Pathway-Dependent Relative Efficacy at Serotonin Type 2A and 2C Receptors: Evidence for Agonist-Directed Trafficking of Receptor Stimulus

  Kelly A. Berg, Saul Maayani, Joseph Goldfarb, Clare Scaramellini, Paul Leff and William P. Clarke

  Molecular Pharmacology July 1998, 54 (1) 94-104; DOI: https://doi.org/10.1124/mol.54.1.94
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  Differential Response of Estrogen Receptor α and Estrogen Receptor β to Partial Estrogen Agonists/Antagonists

  Tomas Barkhem, Bo Carlsson, Yvonne Nilsson, Eva Enmark, Jan-Åke Gustafsson and Stefan Nilsson

  Molecular Pharmacology July 1998, 54 (1) 105-112; DOI: https://doi.org/10.1124/mol.54.1.105
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  Molecular Basis for the Lack of HERG K⁺ Channel Block-Related Cardiotoxicity by the H₁ Receptor Blocker Cetirizine Compared with Other Second-Generation Antihistamines

  Maurizio Taglialatela, Anna Pannaccione, Pasqualina Castaldo, Giovanna Giorgio, Zhengfeng Zhou, Craig T. January, Arturo Genovese, Gianni Marone and Lucio Annunziato

  Molecular Pharmacology July 1998, 54 (1) 113-121; DOI: https://doi.org/10.1124/mol.54.1.113
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  Regulation of Adenylyl Cyclase Type V/VI in Smooth Muscle: Interplay of Inhibitory G Protein and Ca²⁺ Influx

  Karnam S. Murthy and Gabriel M. Makhlouf

  Molecular Pharmacology July 1998, 54 (1) 122-128; DOI: https://doi.org/10.1124/mol.54.1.122
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  Ligand Specificity of the Genetic Variants of Human α₁-Acid Glycoprotein: Generation of a Three-Dimensional Quantitative Structure-Activity Relationship Model for Drug Binding to the A Variant

  Françoise Hervé, Giulia Caron, Jean-Claude Duché, Patrick Gaillard, Noorsaadah Abd. Rahman, Anna Tsantili-Kakoulidou, Pierre-Alain Carrupt, Philippe d’Athis, Jean-Paul Tillement and Bernard Testa

  Molecular Pharmacology July 1998, 54 (1) 129-138; DOI: https://doi.org/10.1124/mol.54.1.129
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  Identification of a [³H]Ligand for the Common Allosteric Site of Muscarinic Acetylcholine M₂ Receptors

  Christian Tränkle, Elisabeth Mies-Klomfass, Mario H. Botero Cid, Ulrike Holzgrabe and Klaus Mohr

  Molecular Pharmacology July 1998, 54 (1) 139-145; DOI: https://doi.org/10.1124/mol.54.1.139
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  Mutations at Lipid-Exposed Residues of the Acetylcholine Receptor Affect Its Gating Kinetics

  Cecilia Bouzat, Ana M. Roccamo, Ingrid Garbus and F. J. Barrantes

  Molecular Pharmacology July 1998, 54 (1) 146-153; DOI: https://doi.org/10.1124/mol.54.1.146
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  Chimeric Melanocortin MC1 and MC3 Receptors: Identification of Domains Participating in Binding of Melanocyte-Stimulating Hormone Peptides

  Helgi B. Schiöth, Philip Yook, Ruta Muceniece, Jarl E. S. Wikberg and Michael Szardenings

  Molecular Pharmacology July 1998, 54 (1) 154-161; DOI: https://doi.org/10.1124/mol.54.1.154
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  Structural Determinants of Potency and Stereoselective Block of hKv1.5 Channels Induced by Local Anesthetics

  Mónica Longobardo, Eva Delpón, Ricardo Caballero, Juan Tamargo and Carmen Valenzuela

  Molecular Pharmacology July 1998, 54 (1) 162-169; DOI: https://doi.org/10.1124/mol.54.1.162
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  Access to Hematin: The Basis of Chloroquine Resistance

  Patrick G. Bray, Mathirut Mungthin, Robert G. Ridley and Stephen A. Ward

  Molecular Pharmacology July 1998, 54 (1) 170-179; DOI: https://doi.org/10.1124/mol.54.1.170
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  Human Platelets and Polymorphonuclear Leukocytes Synthesize Oxygenated Derivatives of Arachidonylethanolamide (Anandamide): Their Affinities for Cannabinoid Receptors and Pathways of Inactivation

  William S. Edgemond, Cecilia J. Hillard, J. R. Falck, Christopher S. Kearn and William B. Campbell

  Molecular Pharmacology July 1998, 54 (1) 180-188; DOI: https://doi.org/10.1124/mol.54.1.180
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  Molecular Basis for Differential Inhibition of Glutamate Transporter Subtypes by Zinc Ions

  Robert J. Vandenberg, Ann D. Mitrovic and Graham A. R. Johnston

  Molecular Pharmacology July 1998, 54 (1) 189-196; DOI: https://doi.org/10.1124/mol.54.1.189
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  The Biophysical and Pharmacological Characteristics of Skeletal Muscle ATP-Sensitive K⁺ Channels Are Modified in K⁺-Depleted Rat, an Animal Model of Hypokalemic Periodic Paralysis

  Domenico Tricarico, Sabata Pierno, Rosanna Mallamaci, Giovanni Siro Brigiani, Raffaele Capriulo, Giuseppe Santoro and Diana Conte Camerino

  Molecular Pharmacology July 1998, 54 (1) 197-206; DOI: https://doi.org/10.1124/mol.54.1.197
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  Activation of Soluble Guanylyl Cyclase by the Nitrovasodilator 3-Morpholinosydnonimine Involves Formation ofS-Nitrosoglutathione

  Astrid Schrammel, Silvia Pfeiffer, Kurt Schmidt, Doris Koesling and Bernd Mayer

  Molecular Pharmacology July 1998, 54 (1) 207-212; DOI: https://doi.org/10.1124/mol.54.1.207
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  Sensitivity to Cisplatin and Platinum-Containing Compounds ofSchizosaccharomyces pombe Rad Mutants

  Paola Perego, Franco Zunino, Nives Carenini, Fernando Giuliani, Silvano Spinelli and Stephen B. Howell

  Molecular Pharmacology July 1998, 54 (1) 213-219; DOI: https://doi.org/10.1124/mol.54.1.213
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  A Novel Benzodiazepine that Activates Cardiac Slow Delayed Rectifier K⁺ Currents

  Joseph J. Salata, Nancy K. Jurkiewicz, Jixin Wang, Ben E. Evans, Heidi T. Orme and Michael C. Sanguinetti

  Molecular Pharmacology July 1998, 54 (1) 220-230; DOI: https://doi.org/10.1124/mol.54.1.220