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Research ArticleArticle

Photoaffinity Labeling of the Benzodiazepine Binding Site of α1β3γ2 γ-Aminobutyric AcidA Receptors with Flunitrazepam Identifies a Subset of Ligands that Interact Directly with His102 of the α Subunit and Predicts Orientation of These within the Benzodiazepine Pharmacophore

Ruth M. McKernan, Sophie Farrar, Ian Collins, Frances Emms, Ayodeji Asuni, Kathleen Quirk and Howard Broughton
Molecular Pharmacology July 1998, 54 (1) 33-43; DOI: https://doi.org/10.1124/mol.54.1.33

Article Information

vol. 54 no. 1 33-43
DOI 
https://doi.org/10.1124/mol.54.1.33
PubMed 
9658187
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received December 26, 1997
  • Accepted March 13, 1998
  • Published online July 1, 1998.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Ruth M. McKernan1,
  2. Sophie Farrar1,
  3. Ian Collins2,
  4. Frances Emms1,
  5. Ayodeji Asuni1,
  6. Kathleen Quirk1, and
  7. Howard Broughton2
  1. Departments of 1Biochemistry (R.M.M., S.F., F.E., A.A., K.Q.) and 2Chemistry (I.C., H.B.), Merck Sharp and Dohme Research Laboratories, Harlow, Essex, UK CM2O 2QR
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Research ArticleArticle

Photoaffinity Labeling of the Benzodiazepine Binding Site of α1β3γ2 γ-Aminobutyric AcidA Receptors with Flunitrazepam Identifies a Subset of Ligands that Interact Directly with His102 of the α Subunit and Predicts Orientation of These within the Benzodiazepine Pharmacophore

Ruth M. McKernan, Sophie Farrar, Ian Collins, Frances Emms, Ayodeji Asuni, Kathleen Quirk and Howard Broughton
Molecular Pharmacology July 1, 1998, 54 (1) 33-43; DOI: https://doi.org/10.1124/mol.54.1.33
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