Table of Contents

Articles

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  Increased Site-Specific Phosphorylation of Tyrosine Hydroxylase Accompanies Stimulation of Enzymatic Activity Induced by Cessation of Dopamine Neuronal Activity

  Jow Y. Lew, Antonio Garcia-Espana, Kwan Y. Lee, Kenneth D. Carr, Menek Goldstein, John W. Haycock and Emanuel Meller

  Molecular Pharmacology February 1999, 55 (2) 202-209; DOI: https://doi.org/10.1124/mol.55.2.202
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  Pivotal Role of an Aspartate Residue in Sodium Sensitivity and Coupling to G Proteins of Neurotensin Receptors

  Stéphane Martin, Jean-Marie Botto, Jean-Pierre Vincent and Jean Mazella

  Molecular Pharmacology February 1999, 55 (2) 210-215; DOI: https://doi.org/10.1124/mol.55.2.210
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  DNA Damage Signals Induction of Fas Ligand in Tumor Cells

  Yin-Yuan Mo and William T. Beck

  Molecular Pharmacology February 1999, 55 (2) 216-222; DOI: https://doi.org/10.1124/mol.55.2.216
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  Autoantibodies against Cytochromes P-4502E1 and P-4503A in Alcoholics

  Simon D. Lytton, Anders Helander, Zhi-Qi Zhang-Gouillon, Knut Stokkeland, Roberta Bordone, Sarino Aricò, Emanuele Albano, Samuel W. French and Magnus Ingelman-Sundberg

  Molecular Pharmacology February 1999, 55 (2) 223-233; DOI: https://doi.org/10.1124/mol.55.2.223
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  Characterization of a Bioengineered Chimeric Na⁺-Nucleoside Transporter

  Juan Wang and Kathleen M. Giacomini

  Molecular Pharmacology February 1999, 55 (2) 234-240; DOI: https://doi.org/10.1124/mol.55.2.234
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  Use of Chimeric Enzymes and Site-Directed Mutagenesis for Identification of Three Key Residues Responsible for Differences in Steroid Hydroxylation between Canine Cytochromes P-450 3A12 and 3A26

  David J. Fraser, You Qun He, Greg R. Harlow and James R. Halpert

  Molecular Pharmacology February 1999, 55 (2) 241-247; DOI: https://doi.org/10.1124/mol.55.2.241
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  The α9 Nicotinic Acetylcholine Receptor Shares Pharmacological Properties with Type A γ-Aminobutyric Acid, Glycine, and Type 3 Serotonin Receptors

  Carla V. Rothlin, Eleonora Katz, Miguel Verbitsky and A. Belén Elgoyhen

  Molecular Pharmacology February 1999, 55 (2) 248-254; DOI: https://doi.org/10.1124/mol.55.2.248
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  Stimulation of the Extracellular Signal-Regulated Kinase 1/2 Pathway by Human Beta-3 Adrenergic Receptor: New Pharmacological Profile and Mechanism of Activation

  C. C. Gerhardt, J. Gros, A. D. Strosberg and T. Issad

  Molecular Pharmacology February 1999, 55 (2) 255-262; DOI: https://doi.org/10.1124/mol.55.2.255
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  Replacement of Threonine 394 by Alanine Facilitates Internalization and Resensitization of the Rat μ Opioid Receptor

  Ronald Wolf, Thomas Koch, Stefan Schulz, Marcus Klutzny, Helmut Schröder, Evelyn Raulf, Frank Bühling and Volker Höllt

  Molecular Pharmacology February 1999, 55 (2) 263-268; DOI: https://doi.org/10.1124/mol.55.2.263
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  The Steroid Promegestone Is a Noncompetitive Antagonist of theTorpedo Nicotinic Acetylcholine Receptor that Interacts with the Lipid-Protein Interface

  Michael P. Blanton, Yu Xie, Lawrence J. Dangott and Jonathan. B. Cohen

  Molecular Pharmacology February 1999, 55 (2) 269-278; DOI: https://doi.org/10.1124/mol.55.2.269
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  A Novel Positive Regulatory Element That Enhances HamsterCYP2A8 Gene Expression Mediated by Xenobiotic Responsive Element

  Kouichi Kurose, Masahiro Tohkin and Morio Fukuhara

  Molecular Pharmacology February 1999, 55 (2) 279-287; DOI: https://doi.org/10.1124/mol.55.2.279
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  Inhibition of Cardiac L-Type Calcium Channels by Epoxyeicosatrienoic Acids

  Jianyong Chen, Jorge H. Capdevila, Darryl C. Zeldin and Robert L. Rosenberg

  Molecular Pharmacology February 1999, 55 (2) 288-295; DOI: https://doi.org/10.1124/mol.55.2.288
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  No Role for Ca⁺⁺ or Protein Kinase C inAlpha-1A Adrenergic Receptor Activation of Mitogen-Activated Protein Kinase Pathways in Transfected PC12 Cells

  Alf Berts, Hongying Zhong and Kenneth P. Minneman

  Molecular Pharmacology February 1999, 55 (2) 296-303; DOI: https://doi.org/10.1124/mol.55.2.296
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  Inhibition of Astroglial Nitric Oxide Synthase Type 2 Expression by Idazoxan

  D. L. Feinstein, D. J. Reis and S. Regunathan

  Molecular Pharmacology February 1999, 55 (2) 304-308; DOI: https://doi.org/10.1124/mol.55.2.304
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  Dexamethasone Stimulates Human A₁ Adenosine Receptor (A₁AR) Gene Expression through Multiple Regulatory Sites in Promoter B

  Hongzu Ren and Gary L. Stiles

  Molecular Pharmacology February 1999, 55 (2) 309-316; DOI: https://doi.org/10.1124/mol.55.2.309
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  Inhibition of Glucocorticoid Receptor Binding by Nitric Oxide

  Mario D. Galigniana, Graciela Piwien-Pilipuk and Jamil Assreuy

  Molecular Pharmacology February 1999, 55 (2) 317-323; DOI: https://doi.org/10.1124/mol.55.2.317
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  Distinct Mechanisms for Activation of the Opioid Receptor-Like 1 and κ-Opioid Receptors by Nociceptin and Dynorphin A

  Catherine Mollereau, Lionel Mouledous, Sophie Lapalu, Gilles Cambois, Christiane Moisand, Jean-Luc Butour and Jean-Claude Meunier

  Molecular Pharmacology February 1999, 55 (2) 324-331; DOI: https://doi.org/10.1124/mol.55.2.324
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  Three Distinct d-Amino Acid Substitutions Confer Potent Antiangiogenic Activity on an Inactive Peptide Derived from a Thrombospondin-1 Type 1 Repeat

  David W. Dawson, Olga V. Volpert, S. Frieda A. Pearce, Andrew J. Schneider, Roy L. Silverstein, Jack Henkin and Noël P. Bouck

  Molecular Pharmacology February 1999, 55 (2) 332-338; DOI: https://doi.org/10.1124/mol.55.2.332
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  Constitutively Active Alpha-1b Adrenergic Receptor Mutants Display Different Phosphorylation and Internalization Features

  Sakina Mhaouty-Kodja, Larry S. Barak, Alexander Scheer, Liliane Abuin, Dario Diviani, Marc G. Caron and Susanna Cotecchia

  Molecular Pharmacology February 1999, 55 (2) 339-347; DOI: https://doi.org/10.1124/mol.55.2.339
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  A Structure-Based Approach to Nicotinic Receptor Pharmacology

  Stephen E. Ryan and John E. Baenziger

  Molecular Pharmacology February 1999, 55 (2) 348-355; DOI: https://doi.org/10.1124/mol.55.2.348
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  Isolation of cDNAs Encoding Cellular Drug-Binding Proteins Using a Novel Expression Cloning Procedure: Drug-Western

  Hideki Tanaka, Nobuko Ohshima and Hiroyoshi Hidaka

  Molecular Pharmacology February 1999, 55 (2) 356-363; DOI: https://doi.org/10.1124/mol.55.2.356
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  Purine and Pyrimidine Nucleotides Inhibit a Noninactivating K+ Current and Depolarize Adrenal Cortical Cells through a G Protein-Coupled Receptor

  Lin Xu and John J. Enyeart

  Molecular Pharmacology February 1999, 55 (2) 364-376; DOI: https://doi.org/10.1124/mol.55.2.364
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  Enhanced Binding to DNA and Topoisomerase I Inhibition by an Analog of the Antitumor Antibiotic Rebeccamycin Containing an Amino Sugar Residue

  Christian Bailly, Xiaogang Qu, Fabrice Anizon, Michelle Prudhomme, Jean-François Riou and Jonathan B. Chaires

  Molecular Pharmacology February 1999, 55 (2) 377-385; DOI: https://doi.org/10.1124/mol.55.2.377
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  The Startle Disease Mutation Q266H, in the Second Transmembrane Domain of the Human Glycine Receptor, Impairs Channel Gating

  Andrew J. Moorhouse, Patrice Jacques, Peter H. Barry and Peter R. Schofield

  Molecular Pharmacology February 1999, 55 (2) 386-395; DOI: https://doi.org/10.1124/mol.55.2.386
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  Induction of p53-Dependent, Insulin-Like Growth Factor-Binding Protein-3-Mediated Apoptosis in Glioblastoma Multiforme Cells by a Protein Kinase Cα Antisense Oligonucleotide

  Li Shen, Nicholas M. Dean and Robert I. Glazer

  Molecular Pharmacology February 1999, 55 (2) 396-402; DOI: https://doi.org/10.1124/mol.55.2.396