Use of Chimeric Enzymes and Site-Directed Mutagenesis for Identification of Three Key Residues Responsible for Differences in Steroid Hydroxylation between Canine Cytochromes P-450 3A12 and 3A26

David J. Fraser; You Qun He; Greg R. Harlow; James R. Halpert

doi:10.1124/mol.55.2.241

Research ArticleArticle

Use of Chimeric Enzymes and Site-Directed Mutagenesis for Identification of Three Key Residues Responsible for Differences in Steroid Hydroxylation between Canine Cytochromes P-450 3A12 and 3A26

David J. Fraser, You Qun He, Greg R. Harlow and James R. Halpert

Molecular Pharmacology February 1999, 55 (2) 241-247; DOI: https://doi.org/10.1124/mol.55.2.241

David J. Fraser

Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tucson, Arizona

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You Qun He

Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tucson, Arizona

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Greg R. Harlow

Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tucson, Arizona

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James R. Halpert

Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tucson, Arizona

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Molecular Pharmacology

Vol. 55, Issue 2

1 Feb 1999

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Research ArticleArticle

Use of Chimeric Enzymes and Site-Directed Mutagenesis for Identification of Three Key Residues Responsible for Differences in Steroid Hydroxylation between Canine Cytochromes P-450 3A12 and 3A26

David J. Fraser, You Qun He, Greg R. Harlow and James R. Halpert

Molecular Pharmacology February 1, 1999, 55 (2) 241-247; DOI: https://doi.org/10.1124/mol.55.2.241

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Research ArticleArticle

Use of Chimeric Enzymes and Site-Directed Mutagenesis for Identification of Three Key Residues Responsible for Differences in Steroid Hydroxylation between Canine Cytochromes P-450 3A12 and 3A26

David J. Fraser, You Qun He, Greg R. Harlow and James R. Halpert

Molecular Pharmacology February 1, 1999, 55 (2) 241-247; DOI: https://doi.org/10.1124/mol.55.2.241

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