Table of Contents

Articles

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  The Soluble Guanylyl Cyclase Inhibitor 1H-[1,2,4]Oxadiazolo[4,3,-a]quinoxalin-1-one Is a Nonselective Heme Protein Inhibitor of Nitric Oxide Synthase and Other Cytochrome P-450 Enzymes Involved in Nitric Oxide Donor Bioactivation

  Martin Feelisch, Peter Kotsonis, Jan Siebe, Bernd Clement and Harald H. H. W. Schmidt

  Molecular Pharmacology August 1999, 56 (2) 243-253; DOI: https://doi.org/10.1124/mol.56.2.243
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  Intrastriatal Dopamine Injection Induces Apoptosis Through Oxidation-Involved Activation of Transcription Factors AP-1 and NF-κB in Rats

  Yongquan Luo, Akinori Hattori, James Munoz, Zheng-Hong Qin and George S. Roth

  Molecular Pharmacology August 1999, 56 (2) 254-264; DOI: https://doi.org/10.1124/mol.56.2.254
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  Protein Kinase C-Promoted Inhibition of Gα₁₁-Stimulated Phospholipase C-β Activity

  Michelle L. Cunningham, Theresa M. Filtz and T. Kendall Harden

  Molecular Pharmacology August 1999, 56 (2) 265-271; DOI: https://doi.org/10.1124/mol.56.2.265
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  Molecular Characterization of Binding of Substrates and Inhibitors to DT-Diaphorase: Combined Approach Involving Site-Directed Mutagenesis, Inhibitor-Binding Analysis, and Computer Modeling

  Shiuan Chen, Kebin Wu, Di Zhang, Mark Sherman, Richard Knox and Chung S. Yang

  Molecular Pharmacology August 1999, 56 (2) 272-278; DOI: https://doi.org/10.1124/mol.56.2.272
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  Inducible Cyclic AMP Early Repressor Protein in Rat Pinealocytes: A Highly Sensitive Natural Reporter for Regulated Gene Transcription

  Martina Pfeffer, Erik Maronde, Carlos A. Molina, Horst-Werner Korf and Jörg H. Stehle

  Molecular Pharmacology August 1999, 56 (2) 279-289; DOI: https://doi.org/10.1124/mol.56.2.279
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  Photoaffinity Labeling the Torpedo Nicotinic Acetylcholine Receptor with [³H]Tetracaine, a Nondesensitizing Noncompetitive Antagonist

  Richard E. Middleton, Nina P. Strnad and Jonathan B. Cohen

  Molecular Pharmacology August 1999, 56 (2) 290-299; DOI: https://doi.org/10.1124/mol.56.2.290
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  Identification of Amino Acids of the Torpedo Nicotinic Acetylcholine Receptor Contributing to the Binding Site for the Noncompetitive Antagonist [³H]Tetracaine

  Martin J. Gallagher and Jonathan B. Cohen

  Molecular Pharmacology August 1999, 56 (2) 300-307; DOI: https://doi.org/10.1124/mol.56.2.300
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  A Transmembrane Domain of the Sulfonylurea Receptor Mediates Activation of ATP-Sensitive K⁺ Channels by K⁺Channel Openers

  Nathalie D’hahan, Hélène Jacquet, Christophe Moreau, Patrice Catty and Michel Vivaudou

  Molecular Pharmacology August 1999, 56 (2) 308-315; DOI: https://doi.org/10.1124/mol.56.2.308
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  Selective Regulation of G Protein-Coupled Receptor-Mediated Signaling by G Protein-Coupled Receptor Kinase 2 in FRTL-5 Cells: Analysis of Thyrotropin, α_1B-Adrenergic, and A₁ Adenosine Receptor-Mediated Responses

  Luisa Iacovelli, Rossana Franchetti, Deborah Grisolia and Antonio De Blasi

  Molecular Pharmacology August 1999, 56 (2) 316-324; DOI: https://doi.org/10.1124/mol.56.2.316
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  Autoregulation of Bradykinin Receptors: Agonists in the Presence of Interleukin-1β Shift the Repertoire of Receptor Subtypes from B2 to B1 in Human Lung Fibroblasts

  Stephen B. Phagoo, Stephen Poole and L. M. Fredrik Leeb-Lundberg

  Molecular Pharmacology August 1999, 56 (2) 325-333; DOI: https://doi.org/10.1124/mol.56.2.325
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  Agonistic Effect of Buprenorphine in a Nociceptin/OFQ Receptor-Triggered Reporter Gene Assay

  Stephan Wnendt, Thomas Krüger, Elke Janocha, Dieter Hildebrandt and Werner Englberger

  Molecular Pharmacology August 1999, 56 (2) 334-338; DOI: https://doi.org/10.1124/mol.56.2.334
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  Regulation of Nerve Growth Factor Release by Nitric Oxide through Cyclic GMP Pathway in Cortical Glial Cells

  Huabao Xiong, Kiyofumi Yamada, Hussam Jourdi, Meiko Kawamura, Nobuyuki Takei, Daiken Han, Toshitaka Nabeshima and Hiroyuki Nawa

  Molecular Pharmacology August 1999, 56 (2) 339-347; DOI: https://doi.org/10.1124/mol.56.2.339
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  Effects of Guanine, Inosine, and Xanthine Nucleotides on β₂-Adrenergic Receptor/G_s Interactions: Evidence for Multiple Receptor Conformations

  Roland Seifert, Ulrik Gether, Katharina Wenzel-Seifert and Brian K. Kobilka

  Molecular Pharmacology August 1999, 56 (2) 348-358; DOI: https://doi.org/10.1124/mol.56.2.348
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  Selective Killing of Cancer Cells Based on Loss of Heterozygosity and Normal Variation in the Human Genome: A New Paradigm for Anticancer Drug Therapy

  James P. Basilion, Andrea R. Schievella, Erica Burns, Patrice Rioux, Jeffrey C. Olson, Brett P. Monia, Kristina M. Lemonidis, Vincent P. Stanton and David E. Housman

  Molecular Pharmacology August 1999, 56 (2) 359-369; DOI: https://doi.org/10.1124/mol.56.2.359
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  Inhibition of Protein Kinases by Balanol: Specificity within the Serine/Threonine Protein Kinase Subfamily

  Juliana Setyawan, Kazunori Koide, Thomas C. Diller, Mark E. Bunnage, Susan S. Taylor, K. C. Nicolaou and Laurence L. Brunton

  Molecular Pharmacology August 1999, 56 (2) 370-376; DOI: https://doi.org/10.1124/mol.56.2.370
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  Differential and Selective Inhibition of Protein Kinase A and Protein Kinase C in Intact Cells by Balanol Congeners

  Åsa B. Gustafsson and Laurence L. Brunton

  Molecular Pharmacology August 1999, 56 (2) 377-382; DOI: https://doi.org/10.1124/mol.56.2.377
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  Interactions of HIV Protease Inhibitors with ATP-Dependent Drug Export Proteins

  Heike Gutmann, Gert Fricker, Jürgen Drewe, Michael Toeroek and David S. Miller

  Molecular Pharmacology August 1999, 56 (2) 383-389; DOI: https://doi.org/10.1124/mol.56.2.383
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  Effect of Loss of DNA Mismatch Repair on Development of Topotecan-, Gemcitabine-, and Paclitaxel-Resistant Variants after Exposure to Cisplatin

  Xinjian Lin and Stephen B. Howell

  Molecular Pharmacology August 1999, 56 (2) 390-395; DOI: https://doi.org/10.1124/mol.56.2.390
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  Identification and Characterization of Three New Alternatively Spliced μ-Opioid Receptor Isoforms

  Ying-Xian Pan, Jin Xu, Elizabeth Bolan, Catherine Abbadie, Albert Chang, Amy Zuckerman, Grace Rossi and Gavril W. Pasternak

  Molecular Pharmacology August 1999, 56 (2) 396-403; DOI: https://doi.org/10.1124/mol.56.2.396
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  Point Mutations at N434 in D1-S6 of μ1 Na⁺ Channels Modulate Binding Affinity and Stereoselectivity of Local Anesthetic Enantiomers

  Carla Nau, Sho-Ya Wang, Gary R. Strichartz and Ging Kuo Wang

  Molecular Pharmacology August 1999, 56 (2) 404-413; DOI: https://doi.org/10.1124/mol.56.2.404
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  Steric Hindrance Is Not Required for n-Alkanol Cutoff in Soluble Proteins

  Roderic G. Eckenhoff, Jonathan W. Tanner and Jonas S. Johansson

  Molecular Pharmacology August 1999, 56 (2) 414-418; DOI: https://doi.org/10.1124/mol.56.2.414
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  Agonist-Induced Phosphorylation by G Protein-Coupled Receptor Kinases of the EP4 Receptor Carboxyl-Terminal Domain in an EP3/EP4 Prostaglandin E₂ Receptor Hybrid

  Frank Neuschäfer-Rube, Martin Oppermann, Ulrike Möller, Ulrike Böer and Gerhard P. Püschel

  Molecular Pharmacology August 1999, 56 (2) 419-428; DOI: https://doi.org/10.1124/mol.56.2.419
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  Kainate Receptors Coupled to G_i/G_oProteins in the Rat Hippocampus

  Rodrigo A. Cunha, João O. Malva and J. A. Ribeiro

  Molecular Pharmacology August 1999, 56 (2) 429-433; DOI: https://doi.org/10.1124/mol.56.2.429
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  Dopamine Transporter: Transmembrane Phenylalanine Mutations Can Selectively Influence Dopamine Uptake and Cocaine Analog Recognition

  Zhicheng Lin, Wenfei Wang, Theresa Kopajtic, Randal S. Revay and George R. Uhl

  Molecular Pharmacology August 1999, 56 (2) 434-447; DOI: https://doi.org/10.1124/mol.56.2.434