Table of Contents

Articles

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  Inverse Agonism and Neutral Antagonism at α_1a- and α_1b-Adrenergic Receptor Subtypes

  Olivier Rossier, Liliane Abuin, Francesca Fanelli, Amedeo Leonardi and Susanna Cotecchia

  Molecular Pharmacology November 1999, 56 (5) 858-866; DOI: https://doi.org/10.1124/mol.56.5.858
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  Implication of Radical Oxygen Species in Ceramide Generation, c-Jun N-Terminal Kinase Activation and Apoptosis Induced by Daunorubicin

  Véronique Mansat-De Mas, Christine Bezombes, Anne Quillet-Mary, Ali Bettaïeb, Aurélie De Thonel D’orgeix, Guy Laurent and Jean-Pierre Jaffrézou

  Molecular Pharmacology November 1999, 56 (5) 867-874; DOI: https://doi.org/10.1124/mol.56.5.867
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  Binding Pockets of the β₁- and β₂-Adrenergic Receptors for Subtype-Selective Agonists

  Masafumi Isogaya, Yoshiyuki Sugimoto, Ryuji Tanimura, Rie Tanaka, Hideo Kikkawa, Taku Nagao and Hitoshi Kurose

  Molecular Pharmacology November 1999, 56 (5) 875-885; DOI: https://doi.org/10.1124/mol.56.5.875
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  Calcineurin Enhances Acetylcholinesterase mRNA Stability during C2-C12 Muscle Cell Differentiation

  Z. David Luo, Yibin Wang, Guy Werlen, Shelley Camp, Kenneth R. Chien and Palmer Taylor

  Molecular Pharmacology November 1999, 56 (5) 886-894; DOI: https://doi.org/10.1124/mol.56.5.886
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  Activating Mutation of Adenylyl Cyclase Reverses its Inhibition by G Proteins

  Gregor Zimmermann, Dongmei Zhou and Ronald Taussig

  Molecular Pharmacology November 1999, 56 (5) 895-901; DOI: https://doi.org/10.1124/mol.56.5.895
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  δ-Opioid-Induced Liberation of Gβγ Mobilizes Ca²⁺ Stores in NG108-15 Cells

  Shin Hee Yoon, Tak-Man Lo, Horace H. Loh and Stanley A. Thayer

  Molecular Pharmacology November 1999, 56 (5) 902-908; DOI: https://doi.org/10.1124/mol.56.5.902
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  Study of Interaction between Agonists and Asn293 in Helix VI of Human β₂-Adrenergic Receptor

  Helene M. Zuurmond, Jutta Hessling, Klaus Blüml, Martin Lohse and Adriaan P. Ijzerman

  Molecular Pharmacology November 1999, 56 (5) 909-916; DOI: https://doi.org/10.1124/mol.56.5.909
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  Identification and Functional Analysis of Novel cAMP Response Element Binding Protein Splice Variants Lacking the Basic/Leucine Zipper Domain

  Norio Sakai, Lara M. Tolbert and Ronald S. Duman

  Molecular Pharmacology November 1999, 56 (5) 917-925; DOI: https://doi.org/10.1124/mol.56.5.917
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  Neutrophil Inhibitory Factor Abrogates Neutrophil Adhesion by Blockade of CD11a and CD11b β₂ Integrins

  Siu K. Lo, Arshad Rahman, Ning Xu, Ming Yuan Zhou, Pablito Nagpala, Howard A. Jaffe and Asrar B. Malik

  Molecular Pharmacology November 1999, 56 (5) 926-932; DOI: https://doi.org/10.1124/mol.56.5.926
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  m2-Toxin: A Selective Ligand for M2 Muscarinic Receptors

  Jigany M. Carsi, Helene H. Valentine and Lincoln T. Potter

  Molecular Pharmacology November 1999, 56 (5) 933-937; DOI: https://doi.org/10.1124/mol.56.5.933
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  Tumor Suppressor p53 But Not cGMP Mediates NO-Induced Expression of p21 ^{Waf1/Cip1/Sdi1} in Vascular Smooth Muscle Cells

  Akio Ishida, Toshiyuki Sasaguri, Yoshikazu Miwa, Chiya Kosaka, Yoji Taba and Takeo Abumiya

  Molecular Pharmacology November 1999, 56 (5) 938-946; DOI: https://doi.org/10.1124/mol.56.5.938
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  A Role of p75 in NGF-Mediated Down-Regulation of the A_2A Adenosine Receptors in PC12 Cells

  Zhongzhen Nie, Yun Mei, Renae L. Malek, Adriana Marcuzzi, Norman H. Lee and Vickram Ramkumar

  Molecular Pharmacology November 1999, 56 (5) 947-954; DOI: https://doi.org/10.1124/mol.56.5.947
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  Coexpression with the Inward Rectifier K⁺ Channel Kir6.1 Increases the Affinity of the Vascular Sulfonylurea Receptor SUR2B for Glibenclamide

  Ulrich Russ, Annette Hambrock, Ferruh Artunc, Cornelia Löffler-Walz, Yoshiyuki Horio, Yoshihisa Kurachi and Ulrich Quast

  Molecular Pharmacology November 1999, 56 (5) 955-961; DOI: https://doi.org/10.1124/mol.56.5.955
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  Using a Radioalloster to Test Predictions of the Cooperativity Model for Gallamine Binding to the Allosteric Site of Muscarinic Acetylcholine M₂ Receptors

  Christian Tränkle, Oliver Weyand, Alexandra Schröter and Klaus Mohr

  Molecular Pharmacology November 1999, 56 (5) 962-965; DOI: https://doi.org/10.1124/mol.56.5.962
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  Modulation of Cisplatinum Cytotoxicity by p53: Effect of p53-Mediated Apoptosis and DNA Repair

  Jianguo Fan and Joseph R. Bertino

  Molecular Pharmacology November 1999, 56 (5) 966-972; DOI: https://doi.org/10.1124/mol.56.5.966
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  Contribution of Individual Subunits to the Multimeric P2X₂ Receptor: Estimates based on Methanethiosulfonate Block at T336C

  Ron Stoop, Sarah Thomas, François Rassendren, Eric Kawashima, Gary Buell, Annmarie Surprenant and R. Alan North

  Molecular Pharmacology November 1999, 56 (5) 973-981; DOI: https://doi.org/10.1124/mol.56.5.973
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  Lead Inhibition of DNA-Binding Mechanism of Cys₂His₂ Zinc Finger Proteins

  Jay S. Hanas, Justin S. Rodgers, John A. Bantle and Yong-Gang Cheng

  Molecular Pharmacology November 1999, 56 (5) 982-988; DOI: https://doi.org/10.1124/mol.56.5.982
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  Inverse Agonist Properties of Dopaminergic Antagonists at the D_1A Dopamine Receptor: Uncoupling of the D_1ADopamine Receptor from G_s Protein

  Guoping Cai, Hakan Gurdal, Candyce Smith, Hoau-Yan Wang and Eitan Friedman

  Molecular Pharmacology November 1999, 56 (5) 989-996; DOI: https://doi.org/10.1124/mol.56.5.989
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  Domain Exchangeability between the Multidrug Transporter (MDR1) and Phosphatidylcholine Flippase (MDR2)

  Yi Zhou, Michael M. Gottesman and Ira Pastan

  Molecular Pharmacology November 1999, 56 (5) 997-1004; DOI: https://doi.org/10.1124/mol.56.5.997
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  G_i Activator Region of α_2A-Adrenergic Receptors: Distinct Basic Residues Mediate G_i versus G_s Activation

  Susan M. Wade, William K. Lim, Keng-Li Lan, Duane A. Chung, Masakatsu Nanamori and Richard R. Neubig

  Molecular Pharmacology November 1999, 56 (5) 1005-1013; DOI: https://doi.org/10.1124/mol.56.5.1005
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  Tight Association of the Human Mel_1a-Melatonin Receptor and G_i: Precoupling and Constitutive Activity

  Florian Roka, Lena Brydon, Maria Waldhoer, A. Donny Strosberg, Michael Freissmuth, Ralf Jockers and Christian Nanoff

  Molecular Pharmacology November 1999, 56 (5) 1014-1024; DOI: https://doi.org/10.1124/mol.56.5.1014
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  Human Dopamine D₃ Receptors Mediate Mitogen-Activated Protein Kinase Activation Via a Phosphatidylinositol 3-Kinase and an Atypical Protein Kinase C-Dependent Mechanism

  Didier Cussac, Adrian Newman-Tancredi, Valerie Pasteau and Mark J. Millan

  Molecular Pharmacology November 1999, 56 (5) 1025-1030; DOI: https://doi.org/10.1124/mol.56.5.1025
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  Alanine-Scanning Mutagenesis of Transmembrane Domain 6 of the M₁ Muscarinic Acetylcholine Receptor Suggests that Tyr381 Plays Key Roles in Receptor Function

  Stuart D. C. Ward, Carol A. M. Curtis and Edward C. Hulme

  Molecular Pharmacology November 1999, 56 (5) 1031-1041; DOI: https://doi.org/10.1124/mol.56.5.1031
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  Slow Sequential Conformational Changes in Escherichia coli Ribosomes Induced by Lincomycin: Kinetic Evidence

  Sofia Kallia-Raftopoulos and Dimitrios L. Kalpaxis

  Molecular Pharmacology November 1999, 56 (5) 1042-1046; DOI: https://doi.org/10.1124/mol.56.5.1042
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  Ion Dependence of Carrier-Mediated Release in Dopamine or Norepinephrine Transporter-Transfected Cells Questions the Hypothesis of Facilitated Exchange Diffusion

  Christian Pifl and Ernst A. Singer

  Molecular Pharmacology November 1999, 56 (5) 1047-1054; DOI: https://doi.org/10.1124/mol.56.5.1047
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  Activation of Leukotriene Synthesis in Human Neutrophils by Exogenous Arachidonic Acid: Inhibition by Adenosine A_2a Receptor Agonists and Crucial Role of Autocrine Activation by Leukotriene B₄

  Marc E. Surette, Eric Krump, Serge Picard and Pierre Borgeat

  Molecular Pharmacology November 1999, 56 (5) 1055-1062; DOI: https://doi.org/10.1124/mol.56.5.1055
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  Mechanisms of Acquired Resistance to Thymidylate Synthase Inhibitors: The Role of Enzyme Stability

  Maria E. Kitchens, Antonia M. Forsthoefel, Karen W. Barbour, H. Trent Spencer and Franklin G. Berger

  Molecular Pharmacology November 1999, 56 (5) 1063-1070; DOI: https://doi.org/10.1124/mol.56.5.1063
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  N-linked Glycosylation Is Required for Plasma Membrane Localization of D5, but Not D1, Dopamine Receptors in Transfected Mammalian Cells

  Kelly D. Karpa, Michael S. Lidow, Mary T. Pickering, Robert Levenson and Clare Bergson

  Molecular Pharmacology November 1999, 56 (5) 1071-1078; DOI: https://doi.org/10.1124/mol.56.5.1071
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  β2-Adrenergic Receptor Agonists and cAMP Arrest Human Cultured Airway Smooth Muscle Cells in the G₁ Phase of the Cell Cycle: Role of Proteasome Degradation of Cyclin D1

  Alastair G. Stewart, Trudi Harris, Darren J. Fernandes, Leslie C. Schachte, Valentina Koutsoubos, Elizabeth Guida, Claire E. Ravenhall, Peter Vadiveloo and John W. Wilson

  Molecular Pharmacology November 1999, 56 (5) 1079-1086; DOI: https://doi.org/10.1124/mol.56.5.1079
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  Agonist Gating and Isoflurane Potentiation in the Human γ-Aminobutyric Acid Type A Receptor Determined by the Volume of a Second Transmembrane Domain Residue

  Vladimir V. Koltchine, Suzanne E. Finn, Andrew Jenkins, Natalia Nikolaeva, Audrey Lin and Neil L. Harrison

  Molecular Pharmacology November 1999, 56 (5) 1087-1093; DOI: https://doi.org/10.1124/mol.56.5.1087