Table of Contents

Articles

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  Differentiation of Substrate and Nonsubstrate Inhibitors of the High-Affinity, Sodium-Dependent Glutamate Transporters

  Hans P. Koch, Michael P. Kavanaugh, Christopher S. Esslinger, Noah Zerangue, John M. Humphrey, Susan G. Amara, A. Richard Chamberlin and Richard J. Bridges

  Molecular Pharmacology December 1999, 56 (6) 1095-1104; DOI: https://doi.org/10.1124/mol.56.6.1095
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  Domain Interactions Affecting Human DNA Topoisomerase I Catalysis and Camptothecin Sensitivity

  Paola Fiorani, James F. Amatruda, Alessandra Silvestri, Richard H. Butler, Mary-Ann Bjornsti and Piero Benedetti

  Molecular Pharmacology December 1999, 56 (6) 1105-1115; DOI: https://doi.org/10.1124/mol.56.6.1105
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  Dopamine D4/D2 Receptor Selectivity Is Determined by A Divergent Aromatic Microdomain Contained within the Second, Third, and Seventh Membrane-Spanning Segments

  Merrill M. Simpson, Juan A. Ballesteros, Victor Chiappa, Jiayun Chen, Makiko Suehiro, Deborah S. Hartman, Thierry Godel, Lenore A. Snyder, Thomas P. Sakmar and Jonathan A. Javitch

  Molecular Pharmacology December 1999, 56 (6) 1116-1126; DOI: https://doi.org/10.1124/mol.56.6.1116
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  Analysis of Aryl Hydrocarbon Receptor-Mediated Signaling during Physiological Hypoxia Reveals Lack of Competition for the Aryl Hydrocarbon Nuclear Translocator Transcription Factor

  Richard S. Pollenz, Nikos A. Davarinos and Todd P. Shearer

  Molecular Pharmacology December 1999, 56 (6) 1127-1137; DOI: https://doi.org/10.1124/mol.56.6.1127
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  Selective Potentiation of L-Type Calcium Channel Currents by Cocaine in Cardiac Myocytes

  Louis S. Premkumar

  Molecular Pharmacology December 1999, 56 (6) 1138-1142; DOI: https://doi.org/10.1124/mol.56.6.1138
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  Platelet-Derived Growth Factor Inhibits α1D-Adrenergic Receptor Expression in Vascular Smooth Muscle Cells In Vitro and Ex Vivo

  Xiaohua Xin, Nengyu Yang and James E. Faber

  Molecular Pharmacology December 1999, 56 (6) 1143-1151; DOI: https://doi.org/10.1124/mol.56.6.1143
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  Platelet-Derived Growth Factor-BB Inhibits Rat α1D-Adrenergic Receptor Gene Expression in Vascular Smooth Muscle Cells by Inducing AP-2-Like Protein Binding to α1D Proximal Promoter Region

  Xiaohua Xin, Nengyu Yang and James E. Faber

  Molecular Pharmacology December 1999, 56 (6) 1152-1161; DOI: https://doi.org/10.1124/mol.56.6.1152
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  Adenosine Transporters in Bloodstream Forms of Trypanosoma brucei brucei: Substrate Recognition Motifs and Affinity for Trypanocidal Drugs

  Harry P. de Koning and Simon M. Jarvis

  Molecular Pharmacology December 1999, 56 (6) 1162-1170; DOI: https://doi.org/10.1124/mol.56.6.1162
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  Molecular and Functional Characterization of Human P2X₂ Receptors

  Kevin J. Lynch, Edward Touma, Wende Niforatos, Karen L. Kage, Edward C. Burgard, Tim van Biesen, Elizabeth A. Kowaluk and Michael F. Jarvis

  Molecular Pharmacology December 1999, 56 (6) 1171-1181; DOI: https://doi.org/10.1124/mol.56.6.1171
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  Visualizing Differences in Ligand Regulation of Wild-Type and Constitutively Active Mutant β₂-Adrenoceptor-Green Fluorescent Protein Fusion Proteins

  Alison J. McLean, Nicola Bevan, Stephen Rees and Graeme Milligan

  Molecular Pharmacology December 1999, 56 (6) 1182-1191; DOI: https://doi.org/10.1124/mol.56.6.1182
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  Mibefradil Potently Blocks ATP-Activated K⁺ Channels in Adrenal Cells

  Juan Carlos Gomora, Judith A. Enyeart and John J. Enyeart

  Molecular Pharmacology December 1999, 56 (6) 1192-1197; DOI: https://doi.org/10.1124/mol.56.6.1192
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  Regulation of Rat Hepatic Hydroxysteroid Sulfotransferase (SULT2-40/41) Gene Expression by Glucocorticoids: Evidence for a Dual Mechanism of Transcriptional Control

  Melissa Runge-Morris, Wei Wu and Thomas A. Kocarek

  Molecular Pharmacology December 1999, 56 (6) 1198-1206; DOI: https://doi.org/10.1124/mol.56.6.1198
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  Putative Partial Agonist 1-Aminocyclopropanecarboxylic Acid Acts Concurrently as a Glycine-Site Agonist and a Glutamate-Site Antagonist at N-Methyl-d-aspartate Receptors

  Rinat Nahum-Levy, Linda H. Fossom, Phil Skolnick and Morris Benveniste

  Molecular Pharmacology December 1999, 56 (6) 1207-1218; DOI: https://doi.org/10.1124/mol.56.6.1207
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  Effect of Multidrug Resistance-Reversing Agents on Transporting Activity of Human Canalicular Multispecific Organic Anion Transporter

  Zhe-Sheng Chen, Takeshi Kawabe, Mayumi Ono, Shunji Aoki, Tomoyuki Sumizawa, Tatsuhiko Furukawa, Takeshi Uchiumi, Morimasa Wada, Michihiko Kuwano and Shin-Ichi Akiyama

  Molecular Pharmacology December 1999, 56 (6) 1219-1228; DOI: https://doi.org/10.1124/mol.56.6.1219
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  Pivotal Role for the Cytoplasmic Carboxyl-Terminal Tail of a Nonmammalian Gonadotropin-Releasing Hormone Receptor in Cell Surface Expression, Ligand Binding, and Receptor Phosphorylation and Internalization

  Marion Blomenröhr, Anders Heding, Robin Sellar, Rob Leurs, Jan Bogerd, Karin A. Eidne and Gary B. Willars

  Molecular Pharmacology December 1999, 56 (6) 1229-1237; DOI: https://doi.org/10.1124/mol.56.6.1229
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  Differential Interaction of R-Mexiletine with the Local Anesthetic Receptor Site on Brain and Heart Sodium Channel α-Subunits

  Thomas Weiser, Yusheng Qu, William A. Catterall and Todd Scheuer

  Molecular Pharmacology December 1999, 56 (6) 1238-1244; DOI: https://doi.org/10.1124/mol.56.6.1238
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  Site-Directed Mutagenesis Reveals Two Epitopes Involved in the Subtype Selectivity of the Allosteric Interactions of Gallamine at Muscarinic Acetylcholine Receptors

  Ann L. Gnagey, Margaret Seidenberg and John Ellis

  Molecular Pharmacology December 1999, 56 (6) 1245-1253; DOI: https://doi.org/10.1124/mol.56.6.1245
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  Selectivity of the Polyspecific Cation Transporter rOCT1 Is Changed by Mutation of Aspartate 475 to Glutamate

  Valentin Gorboulev, Christopher Volk, Petra Arndt, Aida Akhoundova and Hermann Koepsell

  Molecular Pharmacology December 1999, 56 (6) 1254-1261; DOI: https://doi.org/10.1124/mol.56.6.1254
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  9-(2-Phosphonylmethoxyethyl) Derivatives of Purine Nucleotide Analogs: A Comparison of Their Metabolism and Interaction with Cellular DNA Synthesis

  Pavel Kramata and Kathleen M. Downey

  Molecular Pharmacology December 1999, 56 (6) 1262-1270; DOI: https://doi.org/10.1124/mol.56.6.1262
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  c-Jun N-Terminal Kinase Mediates Apoptotic Signaling Induced byN-(4-Hydroxyphenyl)retinamide

  Yi-Rong Chen, Guisheng Zhou and Tse-Hua Tan

  Molecular Pharmacology December 1999, 56 (6) 1271-1279; DOI: https://doi.org/10.1124/mol.56.6.1271
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  Different Vasoactive Intestinal Polypeptide Receptor Domains Are Involved in the Selective Recognition of Two VPAC₂-Selective Ligands

  Maria G. Juarranz, Jean Van Rampelbergh, Philippe Gourlet, Philippe De Neef, Johnny Cnudde, Patrick Robberecht and Magali Waelbroeck

  Molecular Pharmacology December 1999, 56 (6) 1280-1287; DOI: https://doi.org/10.1124/mol.56.6.1280
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  Cloning, Cell-Type Specificity, and Regulatory Function of the Mouse α_1B-Adrenergic Receptor Promoter

  Michael J. Zuscik, Michael T. Piascik and Dianne M. Perez

  Molecular Pharmacology December 1999, 56 (6) 1288-1297; DOI: https://doi.org/10.1124/mol.56.6.1288
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  Modulation of the K⁺ Channels Encoded by the Human Ether-a-Gogo-Related Gene-1 (hERG1) by Nitric Oxide

  Maurizio Taglialatela, Anna Pannaccione, Silvana Iossa, Pasqualina Castaldo and Lucio Annunziato

  Molecular Pharmacology December 1999, 56 (6) 1298-1308; DOI: https://doi.org/10.1124/mol.56.6.1298
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  Murine Transgenic Cells Lacking DNA Topoisomerase IIβ Are Resistant to Acridines and Mitoxantrone: Analysis of Cytotoxicity and Cleavable Complex Formation

  F. Errington, E. Willmore, M. J. Tilby, L. Li, G. Li, W. Li, B. C. Baguley and C. A. Austin

  Molecular Pharmacology December 1999, 56 (6) 1309-1316; DOI: https://doi.org/10.1124/mol.56.6.1309
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  Bone Marrow Stromal Cell Cytochrome P4501B1 Is Required for Pre-B Cell Apoptosis Induced by 7,12-Dimethylbenz[a]anthracene

  Shawn M. Heidel, Karrie Holston, Jeroen T.M. Buters, Frank J. Gonzalez, Colin R. Jefcoate and Charles J. Czupyrynski

  Molecular Pharmacology December 1999, 56 (6) 1317-1323; DOI: https://doi.org/10.1124/mol.56.6.1317
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  Protective Effects of Triterpene Compounds Against the Cytotoxicity of Cadmium in HepG2 Cells

  Nobuhiko Miura, Yoko Matsumoto, Shinichi Miyairi, Shoji Nishiyama and Akira Naganuma

  Molecular Pharmacology December 1999, 56 (6) 1324-1328; DOI: https://doi.org/10.1124/mol.56.6.1324
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  The Orphan Human Pregnane X Receptor Mediates the Transcriptional Activation of CYP3A4 by Rifampicin through a Distal Enhancer Module

  Bryan Goodwin, Ecushla Hodgson and Christopher Liddle

  Molecular Pharmacology December 1999, 56 (6) 1329-1339; DOI: https://doi.org/10.1124/mol.56.6.1329
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  Altered Drug Interaction and Regulation of Topoisomerase IIβ: Potential Mechanisms Governing Sensitivity of HL-60 Cells to Amsacrine and Etoposide

  Dale R. Grabowski, Katherine A. Holmes, Masako Aoyama, Ying Ye, Lisa A. Rybicki, Ronald M. Bukowski, Mahrukh K. Ganapathi, Ian D. Hickson and Ram Ganapathi

  Molecular Pharmacology December 1999, 56 (6) 1340-1345; DOI: https://doi.org/10.1124/mol.56.6.1340
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  The Mechanism for the Inhibition of Acetylcholinesterases by Irinotecan (CPT-11)

  Helen M. Dodds and Laurent P. Rivory

  Molecular Pharmacology December 1999, 56 (6) 1346-1353; DOI: https://doi.org/10.1124/mol.56.6.1346
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  Intracellular Metabolism of CycloSaligenyl 3′-Azido-2′,3′-dideoxythymidine Monophosphate, a Prodrug of 3′-Azido-2′,3′-dideoxythymidine (Zidovudine)

  Jan Balzarini, Lieve Naesens, S. Aquaro, T. Knispel, C.-F. Perno, E. De Clercq and C. Meier

  Molecular Pharmacology December 1999, 56 (6) 1354-1361; DOI: https://doi.org/10.1124/mol.56.6.1354
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  Agonist Selective Regulation of G Proteins by Cannabinoid CB₁ and CB₂ Receptors

  Michelle Glass and John K. Northup

  Molecular Pharmacology December 1999, 56 (6) 1362-1369; DOI: https://doi.org/10.1124/mol.56.6.1362