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Research ArticleArticle

Selective Potentiation of L-Type Calcium Channel Currents by Cocaine in Cardiac Myocytes

Louis S. Premkumar
Molecular Pharmacology December 1999, 56 (6) 1138-1142; DOI: https://doi.org/10.1124/mol.56.6.1138
Louis S. Premkumar
Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois
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Abstract

Cocaine use poses a major health problem not only because of the dependence it causes but also because of the generation of life-threatening cardiac arrhythmias following overdose. Elucidating the molecular mechanisms of action of cocaine, therefore, remains a critical step in developing treatment for cocaine addiction and preventing cardiac complications. Although the neurotransmitter transporters are suggested to be primary targets for cocaine, the continued drug-seeking behavior of transporter knock-out mice suggests the involvement of additional mechanisms. Several studies have shown that voltage-gated calcium channel blockers can prevent the behavioral and reinforcing effects of the drug and also cocaine-induced cardiac events, including lethal ventricular fibrillation. However, the role of voltage-gated calcium channels in cocaine-induced responses is not clear. Herein, I show that cocaine, in pharmacological doses, selectively and potently enhances L-type calcium channel currents in isolated rat ventricular myocytes. This potentiation by cocaine is due to an increase and decrease, respectively, in the calcium channel opening and closing rates, with no apparent effects on voltage-dependence or single-channel conductance. The effects of cocaine are rapidly reversible and unaffected by prior ATPγS-induced channel phosphorylation. These results suggest that cocaine directly binds and facilitates the opening of L-type calcium channels. Importantly, elevated intracellular calcium levels via this mechanism triggering second messenger pathways and gene activation may contribute to many of the cardiovascular and central nervous system effects of cocaine.

Footnotes

    • Received May 24, 1999.
    • Accepted August 28, 1999.
  • Send reprint requests to: Dr. Louis S. Premkumar, Department of Pharmacology, Southern Illinois University School of Medicine, 801 N. Rutledge St., Springfield, IL 62702. E-mail:lpremkumar{at}wpsmtp.siumed.edu

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Molecular Pharmacology: 56 (6)
Molecular Pharmacology
Vol. 56, Issue 6
1 Dec 1999
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Research ArticleArticle

Selective Potentiation of L-Type Calcium Channel Currents by Cocaine in Cardiac Myocytes

Louis S. Premkumar
Molecular Pharmacology December 1, 1999, 56 (6) 1138-1142; DOI: https://doi.org/10.1124/mol.56.6.1138

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Research ArticleArticle

Selective Potentiation of L-Type Calcium Channel Currents by Cocaine in Cardiac Myocytes

Louis S. Premkumar
Molecular Pharmacology December 1, 1999, 56 (6) 1138-1142; DOI: https://doi.org/10.1124/mol.56.6.1138
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