Table of Contents

Articles

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  Mutational Analysis of the Highly Conserved Arginine within the Glu/Asp-Arg-Tyr Motif of the α_1b-Adrenergic Receptor: Effects on Receptor Isomerization and Activation

  Alexander Scheer, Tommaso Costa, Francesca Fanelli, Pier G. De Benedetti, Sakina Mhaouty-Kodja, Liliane Abuin, Monique Nenniger-Tosato and Susanna Cotecchia

  Molecular Pharmacology February 2000, 57 (2) 219-231;
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  Molecular and Conformational Features of a Transport-Relevant Domain in the C-Terminal Tail of the Vasopressin V₂Receptor

  Gerd Krause, Ricardo Hermosilla, Alexander Oksche, Claudia Rutz, Walter Rosenthal and Ralf Schülein

  Molecular Pharmacology February 2000, 57 (2) 232-242;
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  7- and 10-Substituted Camptothecins: Dependence of Topoisomerase I-DNA Cleavable Complex Formation and Stability on the 7- and 10-Substituents

  Bogdan Vladu, Jan M. Woynarowski, Govindarajan Manikumar, Mansukhlal C. Wani, Monroe E. Wall, Daniel D. Von Hoff and Randy M. Wadkins

  Molecular Pharmacology February 2000, 57 (2) 243-251;
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  β1-Adrenergic Receptors Mediate β3-Adrenergic-Independent Effects of CGP 12177 in Brown Adipose Tissue

  Anish A. Konkar, Ying Zhai and James G. Granneman

  Molecular Pharmacology February 2000, 57 (2) 252-258;
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  Functional Domains and Expression of Truncated Atrial Natriuretic Peptide Receptor-A: The Carboxyl-Terminal Regions Direct the Receptor Internalization and Sequestration in COS-7 Cells

  Kailash N. Pandey, Ravindra Kumar, Ming Li and Huong Nguyen

  Molecular Pharmacology February 2000, 57 (2) 259-267;
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  Molecular Determinants of Mexiletine Structure for Potent and Use-Dependent Block of Skeletal Muscle Sodium Channels

  Annamaria De Luca, Fedele Natuzzi, Jean-Francois Desaphy, Gabriella Loni, Giovanni Lentini, Carlo Franchini, Vincenzo Tortorella and Diana Conte Camerino

  Molecular Pharmacology February 2000, 57 (2) 268-277;
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  Mechanisms of Impaired β-Adrenergic Receptor Signaling in G_αq-Mediated Cardiac Hypertrophy and Ventricular Dysfunction

  Gerald W. Dorn, Nicole M. Tepe, Guangyu Wu, Atsuko Yatani and Stephen B. Liggett

  Molecular Pharmacology February 2000, 57 (2) 278-287;
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  Actions of Cannabinoids on Membrane Properties and Synaptic Transmission in Rat Periaqueductal Gray Neurons In Vitro

  Christopher W. Vaughan, Mark Connor, Elena E. Bagley and MacDonald J. Christie

  Molecular Pharmacology February 2000, 57 (2) 288-295;
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  Selection of Human Leukemic CEM Cells for Resistance to the DNA Topoisomerase II Catalytic Inhibitor ICRF-187 Results in Increased Levels of Topoisomerase IIα and Altered G₂/M Checkpoint and Apoptotic Responses

  Susan E. Morgan, Rhonda S. Cadena, Susana C. Raimondi and William T. Beck

  Molecular Pharmacology February 2000, 57 (2) 296-307;
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  Photoaffinity Labeling and Purification of ZG-16p, a High-Affinity Dihydropyridine Binding Protein of Rat Pancreatic Zymogen Granule Membranes that Regulates a K⁺-Selective Conductance

  Matthias Braun and Frank Thévenod

  Molecular Pharmacology February 2000, 57 (2) 308-316;
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  Role of the Amino Acid 45 Residue in Reduced Folate Carrier Function and Ion-Dependent Transport as Characterized by Site-Directed Mutagenesis

  Rongbao Zhao, Feng Gao, Pi Jun Wang and I. David Goldman

  Molecular Pharmacology February 2000, 57 (2) 317-323;
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  Basic Fibroblast Growth Factor Sensitizes NIH 3T3 Cells to Apoptosis Induced by Cisplatin

  Aaron B. Coleman, Jamil Momand and Susan E. Kane

  Molecular Pharmacology February 2000, 57 (2) 324-333;
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  Eosine-Induced Blockade ofN-Methyl-d-aspartate Channels in Acutely Isolated Rat Hippocampal Neurons

  Alexander I. Sobolevsky, Maria V. Yelshansky and Boris I. Khodorov

  Molecular Pharmacology February 2000, 57 (2) 334-341;
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  Alterations in Subunit Expression, Composition, and Phosphorylation of StriatalN-Methyl-d-Aspartate Glutamate Receptors in a Rat 6-Hydroxydopamine Model of Parkinson's Disease

  Anthone W. Dunah, Yuehua Wang, Robert P. Yasuda, Kimihiko Kameyama, Richard L. Huganir, Barry B. Wolfe and David G. Standaert

  Molecular Pharmacology February 2000, 57 (2) 342-352;
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  Differential Regulation of Prostaglandin F_2αReceptor Isoforms by Protein Kinase C

  Hiromichi Fujino, Dinesh Srinivasan, Kristen L. Pierce and John W. Regan

  Molecular Pharmacology February 2000, 57 (2) 353-358;
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  Drug-Resistant Variants of Escherichia coliThymidylate Synthase: Effects of Substitutions at Pro-254

  Corinne Fantz, David Shaw, William Jennings, Antonia Forsthoefel, Maria Kitchens, Jason Phan, Wladek Minor, Lukasz Lebioda, Franklin G. Berger and H. Trent Spencer

  Molecular Pharmacology February 2000, 57 (2) 359-366;
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  Molecular Determinant of High-Affinity Dofetilide Binding toHERG1 Expressed in Xenopus Oocytes: Involvement of S6 Sites

  James P. Lees-Miller, Yanjun Duan, Guo Qi Teng and Henry J. Duff

  Molecular Pharmacology February 2000, 57 (2) 367-374;
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  The Impact of Functional Vitamin D₃ Receptor Conformations on DNA-Dependent Vitamin D₃ Signaling

  Marcus Quack and Carsten Carlberg

  Molecular Pharmacology February 2000, 57 (2) 375-384;
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  A Designed Peptidomimetic Agonistic Ligand of TrkA Nerve Growth Factor Receptors

  Sergei Maliartchouk, Yangbo Feng, Ljubica Ivanisevic, Thomas Debeir, A. Claudio Cuello, Kevin Burgess and H. Uri Saragovi

  Molecular Pharmacology February 2000, 57 (2) 385-391;
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  Selective Block of Late Currents in the ΔKPQ Na⁺Channel Mutant by Pilsicainide and Lidocaine with Distinct Mechanisms

  Katsushige Ono, Toshihiko Kaku, Naomasa Makita, Akira Kitabatake and Makoto Arita

  Molecular Pharmacology February 2000, 57 (2) 392-400;
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  Post-Transcriptional Regulation of Mouse κ-Opioid Receptor Expression

  Li-Na Wei, Xinli Hu, Jing Bi and Horace Loh

  Molecular Pharmacology February 2000, 57 (2) 401-408;
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  Huprine X is a Novel High-Affinity Inhibitor of Acetylcholinesterase That Is of Interest for Treatment of Alzheimer's Disease

  Pelayo Camps, Bernadette Cusack, William D. Mallender, Rachid El Achab, Jordi Morral, Diego Muñoz-Torrero and Terrone L. Rosenberry

  Molecular Pharmacology February 2000, 57 (2) 409-417;