Table of Contents

Articles

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  Regulation of the Cellular Localization and Signaling Properties of the α_1B- and α_1D-Adrenoceptors by Agonists and Inverse Agonists

  Dan F. McCune, Stephanie E. Edelmann, Jennifer R. Olges, Ginell R. Post, Bruce A. Waldrop, David J. J. Waugh, Dianne M. Perez and Michael T. Piascik

  Molecular Pharmacology April 2000, 57 (4) 659-666; DOI: https://doi.org/10.1124/mol.57.4.659
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  Epidermal Growth Factor Receptor Agonists Increase Expression of Glutamate Transporter GLT-1 in Astrocytes through Pathways Dependent on Phosphatidylinositol 3-Kinase and Transcription Factor NF-κB

  Olga Zelenaia, Brian D. Schlag, Gordon E. Gochenauer, Raquelli Ganel, Wei Song, Jacqueline S. Beesley, Judith B. Grinspan, Jeffrey D. Rothstein and Michael B. Robinson

  Molecular Pharmacology April 2000, 57 (4) 667-678; DOI: https://doi.org/10.1124/mol.57.4.667
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  New Advances in the Transport of Doxorubicin through the Blood-Brain Barrier by a Peptide Vector-Mediated Strategy

  Christophe Rousselle, Philippe Clair, Jeanne-Marie Lefauconnier, Michel Kaczorek, Jean-Michel Scherrmann and Jamal Temsamani

  Molecular Pharmacology April 2000, 57 (4) 679-686; DOI: https://doi.org/10.1124/mol.57.4.679
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  Identification of Distinct Carboxyl-Terminal Domains Mediating Internalization and Down-Regulation of the Hamster α_1B- Adrenergic Receptor

  Jiefa Wang, Lei Wang, Jialin Zheng, Jodi L. Anderson and Myron L. Toews

  Molecular Pharmacology April 2000, 57 (4) 687-694; DOI: https://doi.org/10.1124/mol.57.4.687
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  Interaction of Deoxyguanosine Nucleotide Analogs with Human Telomerase

  Susan W. Tendian and William B. Parker

  Molecular Pharmacology April 2000, 57 (4) 695-699; DOI: https://doi.org/10.1124/mol.57.4.695
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  Preactivation Permits Subsequent Stimulation of Phospholipase C by G_i-Coupled Receptors

  Joy S. C. Chan, Jonathan W. M. Lee, Maurice K. C. Ho and Yung H. Wong

  Molecular Pharmacology April 2000, 57 (4) 700-708; DOI: https://doi.org/10.1124/mol.57.4.700
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  Nitric Oxide Up-Regulates Aldose Reductase Expression in Rat Vascular Smooth Muscle Cells: A Potential Role for Aldose Reductase in Vascular Remodeling

  Han Geuk Seo, Toru Nishinaka and Chihiro Yabe-Nishimura

  Molecular Pharmacology April 2000, 57 (4) 709-717; DOI: https://doi.org/10.1124/mol.57.4.709
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  Hexapeptide and Cyclic Pentapeptide Endothelin Antagonists Directly Activate Pituitary Gonadotropin-Releasing Hormone Receptors

  Dror Yahalom, Yitzhak Koch, Nurit Ben-Aroya and Mati Fridkin

  Molecular Pharmacology April 2000, 57 (4) 718-724; DOI: https://doi.org/10.1124/mol.57.4.718
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  Antisense Inhibition of δ-Opioid Receptor Gene Function In Vivo by Peptide Nucleic Acids

  Graeme L. Fraser, Janna Holmgren, Paul B. S. Clarke and Claes Wahlestedt

  Molecular Pharmacology April 2000, 57 (4) 725-731; DOI: https://doi.org/10.1124/mol.57.4.725
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  Rifampicin Is Not an Activator of Glucocorticoid Receptor

  Alexandra S. Herr, Gabriele M. Wochnik, Marcus C. Rosenhagen, Florian Holsboer and Theo Rein

  Molecular Pharmacology April 2000, 57 (4) 732-737; DOI: https://doi.org/10.1124/mol.57.4.732
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  Differential Inhibition of Multiple cAMP Phosphodiesterase Isozymes by Isoflavones and Tyrphostins

  Michael R. Nichols and Bruce H. Morimoto

  Molecular Pharmacology April 2000, 57 (4) 738-745; DOI: https://doi.org/10.1124/mol.57.4.738
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  Differential Superactivation of Adenylyl Cyclase Isozymes after Chronic Activation of the CB₁ Cannabinoid Receptor

  Man-Hee Rhee, Igal Nevo, Tomer Avidor-Reiss, Rivka Levy and Zvi Vogel

  Molecular Pharmacology April 2000, 57 (4) 746-752; DOI: https://doi.org/10.1124/mol.57.4.746
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  Molecular Cloning and Characterization of a Lysophosphatidic Acid Receptor, Edg-7, Expressed in Prostate

  Dong-Soon Im, Christopher E. Heise, Michael A. Harding, Susan R. George, Brian F. O'Dowd, Dan Theodorescu and Kevin R. Lynch

  Molecular Pharmacology April 2000, 57 (4) 753-759; DOI: https://doi.org/10.1124/mol.57.4.753
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  Interactions of the Human Multidrug Resistance Proteins MRP1 and MRP2 with Organic Anions

  Éva Bakos, Raymond Evers, Emese Sinkó, András Váradi, Piet Borst and Balázs Sarkadi

  Molecular Pharmacology April 2000, 57 (4) 760-768; DOI: https://doi.org/10.1124/mol.57.4.760
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  Loss of Cyclosporin and Azidopine Binding Are Associated with Altered ATPase Activity by a Mutant P-glycoprotein with Deleted Phe³³⁵

  Kevin G. Chen, Norman J. Lacayo, George E. Durán, Dalia Cohen and Branimir I. Sikic

  Molecular Pharmacology April 2000, 57 (4) 769-777; DOI: https://doi.org/10.1124/mol.57.4.769
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  Agonist-Dependent Modulation of G Protein-Coupled Receptor Kinase 2 by Mitogen-Activated Protein Kinases

  Ana Elorza, Susana Sarnago and Federico Mayor

  Molecular Pharmacology April 2000, 57 (4) 778-783; DOI: https://doi.org/10.1124/mol.57.4.778
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  Mutations at Arg486 and Glu571 in Human Topoisomerase IIα Confer Resistance to Amsacrine: Relevance for Antitumor Drug Resistance in Human Cells

  Sandhiya Patel, Beatrice A. Keller and L. Mark Fisher

  Molecular Pharmacology April 2000, 57 (4) 784-791; DOI: https://doi.org/10.1124/mol.57.4.784
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  Down-Regulation of Ceramide Production Abrogates Ionizing Radiation-Induced Cytochrome c Release and Apoptosis

  Steven J. Chmura, Edwardine Nodzenski, Surender Kharbanda, Pramod Pandey, Jose Quintans, Donald W. Kufe and Ralph R. Weichselbaum

  Molecular Pharmacology April 2000, 57 (4) 792-796; DOI: https://doi.org/10.1124/mol.57.4.792
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  Aspirin and Sodium Salicylate Inhibit Endothelin ETA Receptors by an Allosteric Type of Mechanism

  Anne Talbodec, Nathalie Berkane, Virginie Blandin, Jean Philippe Breittmayer, Emile Ferrari, Christian Frelin and Paul Vigne

  Molecular Pharmacology April 2000, 57 (4) 797-804; DOI: https://doi.org/10.1124/mol.57.4.797
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  A Molecularly Identified P2Y Receptor Simultaneously Activates Phospholipase C and Inhibits Adenylyl Cyclase and Is Nonselectively Activated by All Nucleoside Triphosphates

  José L. Boyer, Suzanne M. Delaney, Demetrio Villanueva and T. Kendall Harden

  Molecular Pharmacology April 2000, 57 (4) 805-810; DOI: https://doi.org/10.1124/mol.57.4.805
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  The Multifunctional Deoxynucleoside Kinase of Insect Cells Is a Target for the Development of New Insecticides

  Jan Balzarini, Bart Degrève, Sigrid Hatse, Erik De Clercq, Michael Breuer, Magnus Johansson, Roger Huybrechts and Anna Karlsson

  Molecular Pharmacology April 2000, 57 (4) 811-819; DOI: https://doi.org/10.1124/mol.57.4.811