Figure 1
Anti-ET-1 actions of salicylates in isolated rat aorta. A and B, representative traces showing the contractile action of 100 nM ET-1 and the relaxing actions of the indicated concentrations of aspirin (A) and SA (B). Horizontal bar: 4 min, vertical bar: 0.5 g. C, half-times for salicylate-induced relaxations. Rings were precontracted with 100 nM ET-1 and relaxations were induced by 3, 10, or 30 mM aspirin (open columns) or SA (filled columns). Half-times of the relaxations were determined graphically. Mean ± S.E. (n = 6–9) are shown. D, maximum relaxations induced by salicylates. Rings were precontracted with 100 nM Et-1 and relaxations were induced by 3, 10, or 30 mM aspirin (open columns) or SA (filled columns). Mean ± S.E. (n = 6–9) are shown.