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Molecular Pharmacology

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Table of Contents

August 01, 2000; Volume 58,Issue 2

Accelerated Communications

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    Dual Expression and Differential Regulation of Phosphodiesterase 3A and Phosphodiesterase 3B in Human Vascular Smooth Muscle: Implications for Phosphodiesterase 3 Inhibition in Human Cardiovascular Tissues
    Daniel Palmer and Donald H. Maurice
    Molecular Pharmacology August 2000, 58 (2) 247-252; DOI: https://doi.org/10.1124/mol.58.2.247
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    Modulation of KCNQ2/3 Potassium Channels by the Novel Anticonvulsant Retigabine
    Martin J. Main, Jennifer E. Cryan, Joe R. B. Dupere, Brian Cox, Jeffrey J. Clare and Stephen A. Burbidge
    Molecular Pharmacology August 2000, 58 (2) 253-262; DOI: https://doi.org/10.1124/mol.58.2.253
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    Partial Agonism through a Zinc-Ion Switch Constructed between Transmembrane Domains III and VII in the Tachykinin NK1 Receptor
    Birgitte Holst, Christian E. Elling and Thue W. Schwartz
    Molecular Pharmacology August 2000, 58 (2) 263-270; DOI: https://doi.org/10.1124/mol.58.2.263

Articles

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    The Selective Toxicity of 1-Methyl-4-phenylpyridinium to Dopaminergic Neurons: The Role of Mitochondrial Complex I and Reactive Oxygen Species Revisited
    Ken Nakamura, Vytautas P. Bindokas, Jeremy D. Marks, David A. Wright, David M. Frim, Richard J. Miller and Un Jung Kang
    Molecular Pharmacology August 2000, 58 (2) 271-278; DOI: https://doi.org/10.1124/mol.58.2.271
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    CYP2C40, a Unique Arachidonic Acid 16-Hydroxylase, Is the Major CYP2C in Murine Intestinal Tract
    Cheng-Chung Tsao, Julie Foley, Sherry J. Coulter, Robert Maronpot, Darryl C. Zeldin and Joyce A. Goldstein
    Molecular Pharmacology August 2000, 58 (2) 279-287; DOI: https://doi.org/10.1124/mol.58.2.279
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    Characterization of Naturally Occurring and Recombinant HumanN-Acetyltransferase Variants Encoded byNAT1*
    Jesús H. de León, Kostas P. Vatsis and Wendell W. Weber
    Molecular Pharmacology August 2000, 58 (2) 288-299; DOI: https://doi.org/10.1124/mol.58.2.288
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    Chick Optic Lobe Contains a Developmentally Regulated α2α5β2 Nicotinic Receptor Subtype
    Barbara Balestra, Silvia Vailati, Milena Moretti, Wolfang Hanke, Francesco Clementi and Cecilia Gotti
    Molecular Pharmacology August 2000, 58 (2) 300-311; DOI: https://doi.org/10.1124/mol.58.2.300
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    α-Bungarotoxin-Sensitive Nicotinic Receptors Indirectly Modulate [3H]Dopamine Release in Rat Striatal Slices via Glutamate Release
    Sergio Kaiser and Susan Wonnacott
    Molecular Pharmacology August 2000, 58 (2) 312-318; DOI: https://doi.org/10.1124/mol.58.2.312
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    Involvement of Hepatocyte Nuclear Factor 1 in the Regulation of the UDP-Glucuronosyltransferase 1A7 (UGT1A7) Gene in Rat Hepatocytes
    Richard P. Metz, Diana J. Auyeung, Fay K. Kessler and Joseph K. Ritter
    Molecular Pharmacology August 2000, 58 (2) 319-327; DOI: https://doi.org/10.1124/mol.58.2.319
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    Allelic Variation S268P of the Human μ-Opioid Receptor Affects Both Desensitization and G Protein Coupling
    Thomas Koch, Thomas Kroslak, Marco Averbeck, Peter Mayer, Helmut Schröder, Evelyn Raulf and Volker Höllt
    Molecular Pharmacology August 2000, 58 (2) 328-334; DOI: https://doi.org/10.1124/mol.58.2.328
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    Oatp2 Mediates Bidirectional Organic Solute Transport: A Role for Intracellular Glutathione
    Liqiong Li, Peter J. Meier and Nazzareno Ballatori
    Molecular Pharmacology August 2000, 58 (2) 335-340; DOI: https://doi.org/10.1124/mol.58.2.335
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    Steroid Inhibition of Rat Neuronal Nicotinic α4β2 Receptors Expressed in HEK 293 Cells
    Ken Paradiso, Kimberley Sabey, Alex S. Evers, Charles F. Zorumski, Douglas F. Covey and Joe Henry Steinbach
    Molecular Pharmacology August 2000, 58 (2) 341-351; DOI: https://doi.org/10.1124/mol.58.2.341
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    Complex Involvement of Pertussis Toxin-Sensitive G Proteins in the Regulation of Type 1α Metabotropic Glutamate Receptor Signaling in Baby Hamster Kidney Cells
    Emmanuel Hermans, Ruth Saunders, Julie V. Selkirk, Rajendra Mistry, Stefan R. Nahorski and R. A. John Challiss
    Molecular Pharmacology August 2000, 58 (2) 352-360; DOI: https://doi.org/10.1124/mol.58.2.352
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    Dexamethasone Induces Pregnane X Receptor and Retinoid X Receptor-α Expression in Human Hepatocytes: Synergistic Increase of CYP3A4 Induction by Pregnane X Receptor Activators
    Jean-Marc Pascussi, Lionel Drocourt, Jean-Michel Fabre, Patrick Maurel and Marie-José Vilarem
    Molecular Pharmacology August 2000, 58 (2) 361-372; DOI: https://doi.org/10.1124/mol.58.2.361
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    From Agonist To Antagonist: Fab Fragments of an Agonist-Like Monoclonal Anti-β2-Adrenoceptor Antibody Behave as Antagonists
    Alfredo Mijares, Diane Lebesgue, Gerd Wallukat and Johan Hoebeke
    Molecular Pharmacology August 2000, 58 (2) 373-379; DOI: https://doi.org/10.1124/mol.58.2.373
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    Deletion of Individual Exons and Induction of Soluble Murine Interleukin-5 Receptor-α Chain Expression through Antisense Oligonucleotide-Mediated Redirection of Pre-mRNA Splicing
    James G. Karras, Robert A. McKay, Nicholas M. Dean and Brett P. Monia
    Molecular Pharmacology August 2000, 58 (2) 380-387; DOI: https://doi.org/10.1124/mol.58.2.380
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    Receptor Density and Recycling Affect the Rate of Agonist-Induced Desensitization of μ-Opioid Receptor
    Ping-Yee Law, Laurie J. Erickson, Rachid El-Kouhen, Lee Dicker, Jonathan Solberg, Wei Wang, Emilee Miller, Amy L. Burd and Horace H. Loh
    Molecular Pharmacology August 2000, 58 (2) 388-398; DOI: https://doi.org/10.1124/mol.58.2.388
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    CCK-B/Gastrin Receptor Transmembrane Domain Mutations Selectively Alter Synthetic Agonist Efficacy without Affecting the Activity of Endogenous Peptides
    Michael Bläker, Yong Ren, Lakshmi Seshadri, Edward W. McBride, Martin Beinborn and Alan S. Kopin
    Molecular Pharmacology August 2000, 58 (2) 399-406; DOI: https://doi.org/10.1124/mol.58.2.399
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    Edg2 Receptor Functionality: Giα1 Coexpression and Fusion Protein Studies
    George McAllister, Josephine A. Stanton, Kamran Salim, Emma J. Handford and Margaret S. Beer
    Molecular Pharmacology August 2000, 58 (2) 407-412; DOI: https://doi.org/10.1124/mol.58.2.407
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    The Platelet-Derived Growth Factor Receptor Stimulation of p42/p44 Mitogen-Activated Protein Kinase in Airway Smooth Muscle Involves a G-Protein-Mediated Tyrosine Phosphorylation of Gab1
    Soma Rakhit, Susan Pyne and Nigel J. Pyne
    Molecular Pharmacology August 2000, 58 (2) 413-420; DOI: https://doi.org/10.1124/mol.58.2.413
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    Kinetic Analysis of Agonist-Induced Down-Regulation of the β2-Adrenergic Receptor in BEAS-2B Cells Reveals High- and Low-Affinity Components
    Bruce R. Williams, Roger Barber and Richard B. Clark
    Molecular Pharmacology August 2000, 58 (2) 421-430; DOI: https://doi.org/10.1124/mol.58.2.421
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    Molecular Mechanisms of Butylated Hydroxylanisole-Induced Toxicity: Induction of Apoptosis through Direct Release of Cytochromec
    Rong Yu, Sandhya Mandlekar and A.-N. Tony Kong
    Molecular Pharmacology August 2000, 58 (2) 431-437; DOI: https://doi.org/10.1124/mol.58.2.431
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    Resolution of Inverse Agonist-Induced Up-Regulation from Constitutive Activity of Mutants of the α1b-Adrenoceptor
    Patricia A. Stevens, Nicola Bevan, Stephen Rees and Graeme Milligan
    Molecular Pharmacology August 2000, 58 (2) 438-448; DOI: https://doi.org/10.1124/mol.58.2.438
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    Evidence for Edg-3 Receptor-Mediated Activation ofI K.ACh by Sphingosine-1-Phosphate in Human Atrial Cardiomyocytes
    Herbert M. Himmel, Dagmar Meyer zu Heringdorf, Eva Graf, Dobromir Dobrev, Ariane Kortner, Stephan Schüler, Karl H. Jakobs and Ursula Ravens
    Molecular Pharmacology August 2000, 58 (2) 449-454; DOI: https://doi.org/10.1124/mol.58.2.449
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    The D2s Dopamine Receptor Stimulates Phospholipase D Activity: A Novel Signaling Pathway for Dopamine
    Susan E. Senogles
    Molecular Pharmacology August 2000, 58 (2) 455-462; DOI: https://doi.org/10.1124/mol.58.2.455
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Molecular Pharmacology: 58 (2)
Molecular Pharmacology
Vol. 58, Issue 2
1 Aug 2000
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  • SB-431542 Is a Potent and Specific Inhibitor of Transforming Growth Factor-β Superfamily Type I Activin Receptor-Like Kinase (ALK) Receptors ALK4, ALK5, and ALK7
  • The G-Protein-Coupled Receptors in the Human Genome Form Five Main Families. Phylogenetic Analysis, Paralogon Groups, and Fingerprints
  • Pharmacological Properties of Y-27632, a Specific Inhibitor of Rho-Associated Kinases
  • Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines.
  • The Orphan Human Pregnane X Receptor Mediates the Transcriptional Activation of CYP3A4 by Rifampicin through a Distal Enhancer Module
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