Table of Contents

Articles

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  The Selective Toxicity of 1-Methyl-4-phenylpyridinium to Dopaminergic Neurons: The Role of Mitochondrial Complex I and Reactive Oxygen Species Revisited

  Ken Nakamura, Vytautas P. Bindokas, Jeremy D. Marks, David A. Wright, David M. Frim, Richard J. Miller and Un Jung Kang

  Molecular Pharmacology August 2000, 58 (2) 271-278; DOI: https://doi.org/10.1124/mol.58.2.271
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  CYP2C40, a Unique Arachidonic Acid 16-Hydroxylase, Is the Major CYP2C in Murine Intestinal Tract

  Cheng-Chung Tsao, Julie Foley, Sherry J. Coulter, Robert Maronpot, Darryl C. Zeldin and Joyce A. Goldstein

  Molecular Pharmacology August 2000, 58 (2) 279-287; DOI: https://doi.org/10.1124/mol.58.2.279
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  Characterization of Naturally Occurring and Recombinant HumanN-Acetyltransferase Variants Encoded byNAT1*

  Jesús H. de León, Kostas P. Vatsis and Wendell W. Weber

  Molecular Pharmacology August 2000, 58 (2) 288-299; DOI: https://doi.org/10.1124/mol.58.2.288
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  Chick Optic Lobe Contains a Developmentally Regulated α2α5β2 Nicotinic Receptor Subtype

  Barbara Balestra, Silvia Vailati, Milena Moretti, Wolfang Hanke, Francesco Clementi and Cecilia Gotti

  Molecular Pharmacology August 2000, 58 (2) 300-311; DOI: https://doi.org/10.1124/mol.58.2.300
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  α-Bungarotoxin-Sensitive Nicotinic Receptors Indirectly Modulate [³H]Dopamine Release in Rat Striatal Slices via Glutamate Release

  Sergio Kaiser and Susan Wonnacott

  Molecular Pharmacology August 2000, 58 (2) 312-318; DOI: https://doi.org/10.1124/mol.58.2.312
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  Involvement of Hepatocyte Nuclear Factor 1 in the Regulation of the UDP-Glucuronosyltransferase 1A7 (UGT1A7) Gene in Rat Hepatocytes

  Richard P. Metz, Diana J. Auyeung, Fay K. Kessler and Joseph K. Ritter

  Molecular Pharmacology August 2000, 58 (2) 319-327; DOI: https://doi.org/10.1124/mol.58.2.319
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  Allelic Variation S268P of the Human μ-Opioid Receptor Affects Both Desensitization and G Protein Coupling

  Thomas Koch, Thomas Kroslak, Marco Averbeck, Peter Mayer, Helmut Schröder, Evelyn Raulf and Volker Höllt

  Molecular Pharmacology August 2000, 58 (2) 328-334; DOI: https://doi.org/10.1124/mol.58.2.328
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  Oatp2 Mediates Bidirectional Organic Solute Transport: A Role for Intracellular Glutathione

  Liqiong Li, Peter J. Meier and Nazzareno Ballatori

  Molecular Pharmacology August 2000, 58 (2) 335-340; DOI: https://doi.org/10.1124/mol.58.2.335
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  Steroid Inhibition of Rat Neuronal Nicotinic α4β2 Receptors Expressed in HEK 293 Cells

  Ken Paradiso, Kimberley Sabey, Alex S. Evers, Charles F. Zorumski, Douglas F. Covey and Joe Henry Steinbach

  Molecular Pharmacology August 2000, 58 (2) 341-351; DOI: https://doi.org/10.1124/mol.58.2.341
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  Complex Involvement of Pertussis Toxin-Sensitive G Proteins in the Regulation of Type 1α Metabotropic Glutamate Receptor Signaling in Baby Hamster Kidney Cells

  Emmanuel Hermans, Ruth Saunders, Julie V. Selkirk, Rajendra Mistry, Stefan R. Nahorski and R. A. John Challiss

  Molecular Pharmacology August 2000, 58 (2) 352-360; DOI: https://doi.org/10.1124/mol.58.2.352
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  Dexamethasone Induces Pregnane X Receptor and Retinoid X Receptor-α Expression in Human Hepatocytes: Synergistic Increase of CYP3A4 Induction by Pregnane X Receptor Activators

  Jean-Marc Pascussi, Lionel Drocourt, Jean-Michel Fabre, Patrick Maurel and Marie-José Vilarem

  Molecular Pharmacology August 2000, 58 (2) 361-372; DOI: https://doi.org/10.1124/mol.58.2.361
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  From Agonist To Antagonist: Fab Fragments of an Agonist-Like Monoclonal Anti-β₂-Adrenoceptor Antibody Behave as Antagonists

  Alfredo Mijares, Diane Lebesgue, Gerd Wallukat and Johan Hoebeke

  Molecular Pharmacology August 2000, 58 (2) 373-379; DOI: https://doi.org/10.1124/mol.58.2.373
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  Deletion of Individual Exons and Induction of Soluble Murine Interleukin-5 Receptor-α Chain Expression through Antisense Oligonucleotide-Mediated Redirection of Pre-mRNA Splicing

  James G. Karras, Robert A. McKay, Nicholas M. Dean and Brett P. Monia

  Molecular Pharmacology August 2000, 58 (2) 380-387; DOI: https://doi.org/10.1124/mol.58.2.380
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  Receptor Density and Recycling Affect the Rate of Agonist-Induced Desensitization of μ-Opioid Receptor

  Ping-Yee Law, Laurie J. Erickson, Rachid El-Kouhen, Lee Dicker, Jonathan Solberg, Wei Wang, Emilee Miller, Amy L. Burd and Horace H. Loh

  Molecular Pharmacology August 2000, 58 (2) 388-398; DOI: https://doi.org/10.1124/mol.58.2.388
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  CCK-B/Gastrin Receptor Transmembrane Domain Mutations Selectively Alter Synthetic Agonist Efficacy without Affecting the Activity of Endogenous Peptides

  Michael Bläker, Yong Ren, Lakshmi Seshadri, Edward W. McBride, Martin Beinborn and Alan S. Kopin

  Molecular Pharmacology August 2000, 58 (2) 399-406; DOI: https://doi.org/10.1124/mol.58.2.399
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  Edg2 Receptor Functionality: Giα1 Coexpression and Fusion Protein Studies

  George McAllister, Josephine A. Stanton, Kamran Salim, Emma J. Handford and Margaret S. Beer

  Molecular Pharmacology August 2000, 58 (2) 407-412; DOI: https://doi.org/10.1124/mol.58.2.407
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  The Platelet-Derived Growth Factor Receptor Stimulation of p42/p44 Mitogen-Activated Protein Kinase in Airway Smooth Muscle Involves a G-Protein-Mediated Tyrosine Phosphorylation of Gab1

  Soma Rakhit, Susan Pyne and Nigel J. Pyne

  Molecular Pharmacology August 2000, 58 (2) 413-420; DOI: https://doi.org/10.1124/mol.58.2.413
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  Kinetic Analysis of Agonist-Induced Down-Regulation of the β₂-Adrenergic Receptor in BEAS-2B Cells Reveals High- and Low-Affinity Components

  Bruce R. Williams, Roger Barber and Richard B. Clark

  Molecular Pharmacology August 2000, 58 (2) 421-430; DOI: https://doi.org/10.1124/mol.58.2.421
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  Molecular Mechanisms of Butylated Hydroxylanisole-Induced Toxicity: Induction of Apoptosis through Direct Release of Cytochromec

  Rong Yu, Sandhya Mandlekar and A.-N. Tony Kong

  Molecular Pharmacology August 2000, 58 (2) 431-437; DOI: https://doi.org/10.1124/mol.58.2.431
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  Resolution of Inverse Agonist-Induced Up-Regulation from Constitutive Activity of Mutants of the α_1b-Adrenoceptor

  Patricia A. Stevens, Nicola Bevan, Stephen Rees and Graeme Milligan

  Molecular Pharmacology August 2000, 58 (2) 438-448; DOI: https://doi.org/10.1124/mol.58.2.438
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  Evidence for Edg-3 Receptor-Mediated Activation ofI _K.ACh by Sphingosine-1-Phosphate in Human Atrial Cardiomyocytes

  Herbert M. Himmel, Dagmar Meyer zu Heringdorf, Eva Graf, Dobromir Dobrev, Ariane Kortner, Stephan Schüler, Karl H. Jakobs and Ursula Ravens

  Molecular Pharmacology August 2000, 58 (2) 449-454; DOI: https://doi.org/10.1124/mol.58.2.449
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  The D2s Dopamine Receptor Stimulates Phospholipase D Activity: A Novel Signaling Pathway for Dopamine

  Susan E. Senogles

  Molecular Pharmacology August 2000, 58 (2) 455-462; DOI: https://doi.org/10.1124/mol.58.2.455