Table of Contents

Articles

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  Evidence for Peroxisome Proliferator-Activated Receptor (PPAR)α-Independent Peroxisome Proliferation: Effects of PPARγ/δ-Specific Agonists in PPARα-Null Mice

  John G. DeLuca, Thomas W. Doebber, Linda J. Kelly, Ramon K. Kemp, Sylvain Molon-Noblot, Soumya P. Sahoo, John Ventre, Margaret S. Wu, Jeffrey M. Peters, Frank J. Gonzalez and David E. Moller

  Molecular Pharmacology September 2000, 58 (3) 470-476; DOI: https://doi.org/10.1124/mol.58.3.470
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  Human Adenosine A₁, A_2A, A_2B, and A₃ Receptors Expressed in Chinese Hamster Ovary Cells All Mediate the Phosphorylation of Extracellular-Regulated Kinase 1/2

  Gunnar Schulte and Bertil B. Fredholm

  Molecular Pharmacology September 2000, 58 (3) 477-482; DOI: https://doi.org/10.1124/mol.58.3.477
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  Induction of the Cytochrome P450 Gene CYP26 during Mucous Cell Differentiation of Normal Human Tracheobronchial Epithelial Cells

  Seong Yong Kim, Hiroshi Adachi, Ja Seok Koo and Anton M. Jetten

  Molecular Pharmacology September 2000, 58 (3) 483-490; DOI: https://doi.org/10.1124/mol.58.3.483
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  Stimulation of Sphingosine-1-phosphate Formation by the P2Y₂ Receptor in HL-60 Cells: Ca²⁺ Requirement and Implication in Receptor-Mediated Ca²⁺ Mobilization, but Not MAP Kinase Activation

  Regina Alemany, Britta Sichelschmidt, Dagmar Meyer zu Heringdorf, Holger Lass, Chris J. van Koppen and Karl H. Jakobs

  Molecular Pharmacology September 2000, 58 (3) 491-497; DOI: https://doi.org/10.1124/mol.58.3.491
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  Pharmacological Characterization of Chloride Channels Belonging to the ClC Family by the Use of Chiral Clofibric Acid Derivatives

  Michael Pusch, Antonella Liantonio, Lara Bertorello, Alessio Accardi, Annamaria De Luca, Sabata Pierno, Vincenzo Tortorella and Diana Conte Camerino

  Molecular Pharmacology September 2000, 58 (3) 498-507; DOI: https://doi.org/10.1124/mol.58.3.498
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  Dual Mechanisms of Action of the Retinoid CD437: Nuclear Retinoic Acid Receptor-Mediated Suppression of Squamous Differentiation and Receptor-Independent Induction of Apoptosis in UMSCC22B Human Head and Neck Squamous Cell Carcinoma Cells

  Shi-Yong Sun, Ping Yue, Roshantha A. S. Chandraratna, Yohannes Tesfaigzi, Waun K. Hong and Reuben Lotan

  Molecular Pharmacology September 2000, 58 (3) 508-514; DOI: https://doi.org/10.1124/mol.58.3.508
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  The Bioflavonoid Galangin Blocks Aryl Hydrocarbon Receptor Activation and Polycyclic Aromatic Hydrocarbon-Induced Pre-B Cell Apoptosis

  Shafat A. Quadri, Ariful N. Qadri, Mark E. Hahn, Koren K. Mann and David H. Sherr

  Molecular Pharmacology September 2000, 58 (3) 515-525; DOI: https://doi.org/10.1124/mol.58.3.515
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  2′-Hydroxychalcone Inhibits Nuclear Factor-κB and Blocks Tumor Necrosis Factor-α- and Lipopolysaccharide-Induced Adhesion of Neutrophils to Human Umbilical Vein Endothelial Cells

  Babita Madan, Sanjay Batra and Balaram Ghosh

  Molecular Pharmacology September 2000, 58 (3) 526-534; DOI: https://doi.org/10.1124/mol.58.3.526
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  Selective Activation of the c-Jun N-Terminal Protein Kinase Pathway during 4-Hydroxynonenal-Induced Apoptosis of PC12 Cells

  Yunjo Soh, Kyu-Shik Jeong, Insong James Lee, Myung-Ae Bae, Yong-Chul Kim and Byoung J. Song

  Molecular Pharmacology September 2000, 58 (3) 535-541; DOI: https://doi.org/10.1124/mol.58.3.535
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  Human Microsomal Epoxide Hydrolase Is the Target of Germander-Induced Autoantibodies on the Surface of Human Hepatocytes

  Veronique De Berardinis, Claude Moulis, Michele Maurice, Philippe Beaune, Dominique Pessayre, Denis Pompon and Jacqueline Loeper

  Molecular Pharmacology September 2000, 58 (3) 542-551; DOI: https://doi.org/10.1124/mol.58.3.542
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  Evidence That the Proposed Novel Human “Neurokinin-4” Receptor Is Pharmacologically Similar to the Human Neurokinin-3 Receptor but Is Not of Human Origin

  Henry M. Sarau, Jeffrey L. Mooney, Dulcie B. Schmidt, James J. Foley, Peter T. Buckley, Giuseppe A. M. Giardina, Da Y. Wang, Jonathan A. Lee and Douglas W. P. Hay

  Molecular Pharmacology September 2000, 58 (3) 552-559; DOI: https://doi.org/10.1124/mol.58.3.552
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  Probing the Interaction of the Cytotoxic Bisdioxopiperazine ICRF-193 with the Closed Enzyme Clamp of Human Topoisomerase IIα

  Sandhiya Patel, Elen Jazrawi, Andrew M. Creighton, Caroline A. Austin and L. Mark Fisher

  Molecular Pharmacology September 2000, 58 (3) 560-568; DOI: https://doi.org/10.1124/mol.58.3.560
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  RGS14, a GTPase-Activating Protein for Giα, Attenuates Giα- and G13α-Mediated Signaling Pathways

  Hyeseon Cho, Tohru Kozasa, Kenneth Takekoshi, Jean De Gunzburg and John H. Kehrl

  Molecular Pharmacology September 2000, 58 (3) 569-576; DOI: https://doi.org/10.1124/mol.58.3.569
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  Identification of Acylpeptide Hydrolase as a Sensitive Site for Reaction with Organophosphorus Compounds and a Potential Target for Cognitive Enhancing Drugs

  Paul G. Richards, Martin K. Johnson and David E. Ray

  Molecular Pharmacology September 2000, 58 (3) 577-583; DOI: https://doi.org/10.1124/mol.58.3.577
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  Functional Differences between the Amino-Terminal Domains of Estrogen Receptors α and β

  Franck Delaunay, Katarina Pettersson, Michel Tujague and Jan-Åke Gustafsson

  Molecular Pharmacology September 2000, 58 (3) 584-590; DOI: https://doi.org/10.1124/mol.58.3.584
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  Retigabine, A Novel Anti-Convulsant, Enhances Activation of KCNQ2/Q3 Potassium Channels

  Alan D. Wickenden, Weifeng Yu, Anrou Zou, Tim Jegla and P. Kay Wagoner

  Molecular Pharmacology September 2000, 58 (3) 591-600; DOI: https://doi.org/10.1124/mol.58.3.591
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  Characterization of Gastrin-Releasing Peptide and Its Receptor Aberrantly Expressed by Human Colon Cancer Cell Lines

  Robert E. Carroll, Denis Ostrovskiy, Sean Lee, Alexey Danilkovich and Richard V. Benya

  Molecular Pharmacology September 2000, 58 (3) 601-607; DOI: https://doi.org/10.1124/mol.58.3.601
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  Pertussis Toxin Inhibits Cholecystokinin- and Epidermal Growth Factor-Induced Mitogen-Activated Protein Kinase Activation by Disinhibition of the cAMP Signaling Pathway and Inhibition of c-Raf-1

  Albrecht Piiper, Ralph Gebhardt, Bernd Kronenberger, Claudio D. Giannini, Robert Elez and Stefan Zeuzem

  Molecular Pharmacology September 2000, 58 (3) 608-613; DOI: https://doi.org/10.1124/mol.58.3.608
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  Conantokin G Is an NR2B-Selective Competitive Antagonist ofN-Methyl-d-aspartate Receptors

  Sean D. Donevan and R. Tyler McCabe

  Molecular Pharmacology September 2000, 58 (3) 614-623; DOI: https://doi.org/10.1124/mol.58.3.614
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  Communication between Multiple Drug Binding Sites on P-glycoprotein

  Catherine Martin, Georgina Berridge, Christopher F. Higgins, Prakash Mistry, Peter Charlton and Richard Callaghan

  Molecular Pharmacology September 2000, 58 (3) 624-632; DOI: https://doi.org/10.1124/mol.58.3.624
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  Tetrahydrobiopterin Is Released from and Causes Preferential Death of Catecholaminergic Cells by Oxidative Stress

  Hyun Jin Choi, Yeon Joo Jang, Hyo Jung Kim and Onyou Hwang

  Molecular Pharmacology September 2000, 58 (3) 633-640; DOI: https://doi.org/10.1124/mol.58.3.633
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  Viral Entry as the Primary Target for the Anti-HIV Activity of Chicoric Acid and Its Tetra-Acetyl Esters

  Wim Pluymers, Nouri Neamati, Christophe Pannecouque, Valery Fikkert, Christophe Marchand, Terrence R. Burke, Yves Pommier, Dominique Schols, Erik De Clercq, Zeger Debyser and Myriam Witvrouw

  Molecular Pharmacology September 2000, 58 (3) 641-648; DOI: https://doi.org/10.1124/mol.58.3.641
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  Acridinecarboxamide Topoisomerase Poisons: Structural and Kinetic Studies of the DNA Complexes of 5-Substituted 9-Amino-(N-(2-dimethylamino)ethyl)acridine-4-Carboxamides

  Adrienne Adams, J. Mitchell Guss, Charles A. Collyer, William A. Denny, Arungundrum S. Prakash and Laurence P. G. Wakelin

  Molecular Pharmacology September 2000, 58 (3) 649-658; DOI: https://doi.org/10.1124/mol.58.3.649