Table of Contents

Articles

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  Normoxic Stabilization of Hypoxia-Inducible Factor-1 Expression and Activity: Redox-Dependent Effect of Nitrogen Oxides

  Lisa A. Palmer, Benjamin Gaston and Roger A. Johns

  Molecular Pharmacology December 2000, 58 (6) 1197-1203; DOI: https://doi.org/10.1124/mol.58.6.1197
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  Modulation of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Receptor Desensitization by Extracellular Protons

  Eva C. Ihle and Doris K. Patneau

  Molecular Pharmacology December 2000, 58 (6) 1204-1212; DOI: https://doi.org/10.1124/mol.58.6.1204
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  Tyrosine Phosphatase Inhibitors Selectively Antagonize β-Adrenergic Receptor-Dependent Regulation of Cardiac Ion Channels

  Carl Sims, Jason Chiu and Robert D. Harvey

  Molecular Pharmacology December 2000, 58 (6) 1213-1221; DOI: https://doi.org/10.1124/mol.58.6.1213
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  p53 Interacts with the DNA Mismatch Repair System to Modulate the Cytotoxicity and Mutagenicity of Hydrogen Peroxide

  Xinjian Lin, Krishna Ramamurthi, Misako Mishima, Akira Kondo and Stephen B. Howell

  Molecular Pharmacology December 2000, 58 (6) 1222-1229; DOI: https://doi.org/10.1124/mol.58.6.1222
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  The Use of Stimulus-Biased Assay Systems to Detect Agonist-Specific Receptor Active States: Implications for the Trafficking of Receptor Stimulus by Agonists

  Chris Watson, Grace Chen, Paul Irving, James Way, Wen-Ji Chen and Terry Kenakin

  Molecular Pharmacology December 2000, 58 (6) 1230-1238; DOI: https://doi.org/10.1124/mol.58.6.1230
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  Nuclear Factor I/CCAAT Box Transcription Factor trans-Activating Domain Is a Negative Sensor of Cellular Stress

  Yannick Morel, Xavier Coumoul, Antoine Nalpas and Robert Barouki

  Molecular Pharmacology December 2000, 58 (6) 1239-1246; DOI: https://doi.org/10.1124/mol.58.6.1239
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  Methamphetamine-Induced Neurotoxicity Is Attenuated in Transgenic Mice with a Null Mutation for Interleukin-6

  Bruce Ladenheim, Irina N. Krasnova, Xiaolin Deng, Jonathan M. Oyler, Aldo Polettini, Timothy H. Moran, Marilyn A. Huestis and Jean Lud Cadet

  Molecular Pharmacology December 2000, 58 (6) 1247-1256; DOI: https://doi.org/10.1124/mol.58.6.1247
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  Molecular and Functional Characterization of HSC54, a Novel Variant of Human Heat-Shock Cognate Protein 70

  Fujiko Tsukahara, Toshimasa Yoshioka and Takamura Muraki

  Molecular Pharmacology December 2000, 58 (6) 1257-1263; DOI: https://doi.org/10.1124/mol.58.6.1257
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  Molecular Determinants of Diltiazem Block in Domains IIIS6 and IVS6 of L-type Ca²⁺ Channels

  Gregory H. Hockerman, Nejmi Dilmac, Todd Scheuer and William A. Catterall

  Molecular Pharmacology December 2000, 58 (6) 1264-1270; DOI: https://doi.org/10.1124/mol.58.6.1264
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  Regulation of Central Synaptic Transmission by 5-HT_1BAuto- and Heteroreceptors

  Hitoshi Morikawa, Olivier J. Manzoni, John C. Crabbe and John T. Williams

  Molecular Pharmacology December 2000, 58 (6) 1271-1278; DOI: https://doi.org/10.1124/mol.58.6.1271
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  Comparison of Agonist-Induced Internalization of the Human EP2 and EP4 Prostaglandin Receptors: Role of the Carboxyl Terminus in EP4 Receptor Sequestration

  Snehal Desai, Heather April, Chinwe Nwaneshiudu and Barrie Ashby

  Molecular Pharmacology December 2000, 58 (6) 1279-1286; DOI: https://doi.org/10.1124/mol.58.6.1279
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  Huanglian, A Chinese Herbal Extract, Inhibits Cell Growth by Suppressing the Expression of Cyclin B1 and Inhibiting CDC2 Kinase Activity in Human Cancer Cells

  Xiao-Kui Li, Monica Motwani, William Tong, William Bornmann and Gary K. Schwartz

  Molecular Pharmacology December 2000, 58 (6) 1287-1293; DOI: https://doi.org/10.1124/mol.58.6.1287
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  Nuclear Factor-κB Mediates Simultaneous Induction of Inducible Nitric-Oxide Synthase and Up-Regulation of the Cationic Amino Acid Transporter CAT-2B in Rat Alveolar Macrophages

  Rainer Hammermann, Maria Donata Messeri Dreißig, Jutta Mössner, Margarita Fuhrmann, Liberato Berrino, Manfred Göthert and Kurt Racké

  Molecular Pharmacology December 2000, 58 (6) 1294-1302; DOI: https://doi.org/10.1124/mol.58.6.1294
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  Differential Fibronectin Expression in Activated C6 Glial Cells Treated with Ethanol

  Li Q. Ren, Daniel K. Garrett, Marie Syapin and Peter J. Syapin

  Molecular Pharmacology December 2000, 58 (6) 1303-1309; DOI: https://doi.org/10.1124/mol.58.6.1303
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  Characterization of the Binding Site for a Novel Class of Noncompetitive α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Receptor Antagonists

  Frank S. Menniti, Bertrand L. Chenard, Mary B. Collins, Mary F. Ducat, Mark L. Elliott, Frank E. Ewing, Jianhua I. Huang, Kristin A. Kelly, John T. Lazzaro, Martin J. Pagnozzi, James L. Weeks, Willard M. Welch and W. Frost White

  Molecular Pharmacology December 2000, 58 (6) 1310-1317; DOI: https://doi.org/10.1124/mol.58.6.1310
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  Differential Response of K_ATP Channels Containing SUR2A or SUR2B Subunits to Nucleotides and Pinacidil

  Frank Reimann, Fiona M. Gribble and Frances M. Ashcroft

  Molecular Pharmacology December 2000, 58 (6) 1318-1325; DOI: https://doi.org/10.1124/mol.58.6.1318
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  Selective Abolishment of Pyrimidine Nucleoside Kinase Activity of Herpes Simplex Virus Type 1 Thymidine Kinase by Mutation of Alanine-167 to Tyrosine

  Bart Degrève, Robert Esnouf, Erik De Clercq and Jan Balzarini

  Molecular Pharmacology December 2000, 58 (6) 1326-1332; DOI: https://doi.org/10.1124/mol.58.6.1326
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  Decoy Oligodeoxynucleotide Characterization of Transcription Factors Controlling Endothelin-B Receptor Expression in Vascular Smooth Muscle Cells

  Andreas H. Wagner, Robert Krzesz, Dingcheng Gao, Christian Schroeder, Marco Cattaruzza and Markus Hecker

  Molecular Pharmacology December 2000, 58 (6) 1333-1340; DOI: https://doi.org/10.1124/mol.58.6.1333
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  Identification of Human Cytochrome P450s Involved in the Formation of All-trans-Retinoic Acid Principal Metabolites

  Julie Marill, Thierry Cresteil, Michel Lanotte and Guy G. Chabot

  Molecular Pharmacology December 2000, 58 (6) 1341-1348; DOI: https://doi.org/10.1124/mol.58.6.1341
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  Why Are A_2B Receptors Low-Affinity Adenosine Receptors? Mutation of Asn273 to Tyr Increases Affinity of Human A_2B Receptor for 2-(1-Hexynyl)adenosine

  Margot W. Beukers, Hans den Dulk, Erica W. van Tilburg, Jaap Brouwer and Adriaan P. Ijzerman

  Molecular Pharmacology December 2000, 58 (6) 1349-1356; DOI: https://doi.org/10.1124/mol.58.6.1349
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  Xenobiotic Transport across Isolated Brain Microvessels Studied by Confocal Microscopy

  David S. Miller, Stephanie N. Nobmann, Heike Gutmann, Michael Toeroek, Juergen Drewe and Gert Fricker

  Molecular Pharmacology December 2000, 58 (6) 1357-1367; DOI: https://doi.org/10.1124/mol.58.6.1357
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  2-Aminoethoxydiphenyl Borate Modulates Kinetics of Intracellular Ca²⁺ Signals Mediated by Inositol 1,4,5-Trisphosphate-Sensitive Ca²⁺ Stores in Single Pancreatic Acinar Cells of Mouse

  Jie Wu, Noritaka Kamimura, Teruko Takeo, Sechiko Suga, Makoto Wakui, Takayuki Maruyama and Katsuhiko Mikoshiba

  Molecular Pharmacology December 2000, 58 (6) 1368-1374; DOI: https://doi.org/10.1124/mol.58.6.1368
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  Correlation of the Apparent Affinities and Efficacies of γ-Aminobutyric Acid_C Receptor Agonists

  Yongchang Chang, Douglas F. Covey and David S. Weiss

  Molecular Pharmacology December 2000, 58 (6) 1375-1380; DOI: https://doi.org/10.1124/mol.58.6.1375
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  The Third Intracellular Loop of the Rat and Mouse Cholecystokinin-A Receptors Is Responsible for Different Patterns of Gene Activation

  Roya Poosti, Laure di Malta, Didier Gagne, Nicole Bernad, Jean-Claude Galleyrand, Chantal Escrieut, Sandrine Silvente-Poirot, Daniel Fourmy and Jean Martinez

  Molecular Pharmacology December 2000, 58 (6) 1381-1388; DOI: https://doi.org/10.1124/mol.58.6.1381
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  Inhibition of Protein Isoprenylation Impairs Rho-Regulated Early Cellular Response to Genotoxic Stress

  Renate Gnad, Klaus Aktories, Bernd Kaina and Gerhard Fritz

  Molecular Pharmacology December 2000, 58 (6) 1389-1397; DOI: https://doi.org/10.1124/mol.58.6.1389
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  Induction of p27^KIP1 as a Mechanism Underlying NS398-Induced Growth Inhibition in Human Lung Cancer Cells

  Wen-Chun Hung, Hui-Chiu Chang, Mei-Ren Pan, Te-Hsiu Lee and Lea-Yea Chuang

  Molecular Pharmacology December 2000, 58 (6) 1398-1403; DOI: https://doi.org/10.1124/mol.58.6.1398
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  Structural Domains of Chimeric Dopamine-Noradrenaline Human Transporters Involved in the Na⁺- and Cl⁻-Dependence of Dopamine Transport

  Maria Syringas, François Janin, Sana Mezghanni, Bruno Giros, Jean Costentin and Jean-Jacques Bonnet

  Molecular Pharmacology December 2000, 58 (6) 1404-1411; DOI: https://doi.org/10.1124/mol.58.6.1404
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  Modeling the Functional Effects of Allosteric Modulators at Pharmacological Receptors: An Extension of the Two-State Model of Receptor Activation

  David A. Hall

  Molecular Pharmacology December 2000, 58 (6) 1412-1423; DOI: https://doi.org/10.1124/mol.58.6.1412
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  Impaired Resensitization and Recycling of the Cholecystokinin Receptor by Co-expression of its Second Intracellular Loop

  Xi-Qin Ding, Rammohan V. Rao, Susan M. Kuntz, Eileen L. Holicky and Laurence J. Miller

  Molecular Pharmacology December 2000, 58 (6) 1424-1433; DOI: https://doi.org/10.1124/mol.58.6.1424
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  A Single Amino Acid Residue on the α₅ Subunit (Ile215) Is Essential for Ligand Selectivity at α₅β₃γ₂ γ-Aminobutyric Acid_A Receptors

  Marina I. Strakhova, Scott C. Harvey, Christine M. Cook, James M. Cook and Phil Skolnick

  Molecular Pharmacology December 2000, 58 (6) 1434-1440; DOI: https://doi.org/10.1124/mol.58.6.1434
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  Dexamethasone Enhances Constitutive Androstane Receptor Expression in Human Hepatocytes: Consequences on Cytochrome P450 Gene Regulation

  Jean-Marc Pascussi, Sabine Gerbal-Chaloin, Jean-Michel Fabre, Patrick Maurel and Marie-José Vilarem

  Molecular Pharmacology December 2000, 58 (6) 1441-1450; DOI: https://doi.org/10.1124/mol.58.6.1441
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  Interactions of Alcuronium, TMB-8, and Other Allosteric Ligands with Muscarinic Acetylcholine Receptors: Studies with Chimeric Receptors

  John Ellis and Margaret Seidenberg

  Molecular Pharmacology December 2000, 58 (6) 1451-1460; DOI: https://doi.org/10.1124/mol.58.6.1451
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  Allosteric Inhibition of Endothelin ETA Receptors by 3,5-Dibromosalicylic Acid

  Virginie Blandin, Paul Vigne, Jean Philippe Breittmayer and Christian Frelin

  Molecular Pharmacology December 2000, 58 (6) 1461-1469; DOI: https://doi.org/10.1124/mol.58.6.1461
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  β-Adrenergic Stimulation of Rat Cardiac Fibroblasts Enhances Induction of Nitric-Oxide Synthase by Interleukin-1β via Message Stabilization

  Åsa B. Gustafsson and Laurence L. Brunton

  Molecular Pharmacology December 2000, 58 (6) 1470-1478; DOI: https://doi.org/10.1124/mol.58.6.1470
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  Protein Kinase Cα but not p44/42 Mitogen-Activated Protein Kinase, p38, or c-Jun NH₂-Terminal Kinase Is Required for Intercellular Adhesion Molecule-1 Expression Mediated by Interleukin-1β: Involvement of Sequential Activation of Tyrosine Kinase, Nuclear Factor-κB-Inducing Kinase, and IκB Kinase 2

  Ching-Chow Chen, Jun-Jie Chen and Chian-Ying Chou

  Molecular Pharmacology December 2000, 58 (6) 1479-1489; DOI: https://doi.org/10.1124/mol.58.6.1479
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  Glycosylation of the Gastrin-Releasing Peptide Receptor and Its Effect on Expression, G Protein Coupling, and Receptor Modulatory Processes

  Richard V. Benya, Takashi Kusui, Tatsuro Katsuno, Takaharu Tsuda, Samuel A. Mantey, James F. Battey and Robert T. Jensen

  Molecular Pharmacology December 2000, 58 (6) 1490-1501; DOI: https://doi.org/10.1124/mol.58.6.1490
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  Competitive Antagonism of Recombinant P2X_2/3Receptors by 2′,3′-O-(2,4,6-Trinitrophenyl) Adenosine 5′-Triphosphate (TNP-ATP)

  Edward C. Burgard, Wende Niforatos, Tim van Biesen, Kevin J. Lynch, Karen L. Kage, Edward Touma, Elizabeth A. Kowaluk and Michael F. Jarvis

  Molecular Pharmacology December 2000, 58 (6) 1502-1510; DOI: https://doi.org/10.1124/mol.58.6.1502
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  Synthetic Modification of Prostaglandin F_2αIndicates Different Structural Determinants for Binding to the Prostaglandin F Receptor Versus the Prostaglandin Transporter

  Victor L. Schuster, Shigekazu Itoh, Steven W. Andrews, Robert M. Burk, June Chen, Karen M. Kedzie, Daniel W. Gil and David F. Woodward

  Molecular Pharmacology December 2000, 58 (6) 1511-1516; DOI: https://doi.org/10.1124/mol.58.6.1511
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  A Tetratricopeptide Repeat Half-Site in the Aryl Hydrocarbon Receptor Is Important for DNA Binding andtrans-Activation Potential

  Steven L. Levine, John R. Petrulis, Allison Dubil and Gary H. Perdew

  Molecular Pharmacology December 2000, 58 (6) 1517-1524; DOI: https://doi.org/10.1124/mol.58.6.1517
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  Replacement of an NH₃ by an Iminoether in Transplatin Makes an Antitumor Drug from an Inactive Compound

  Marc Leng, Daniel Locker, Marie-Josèphe Giraud-Panis, Annie Schwartz, Francesco P. Intini, Giovanni Natile, Claudio Pisano, Angelina Boccarelli, Domenico Giordano and Mauro Coluccia

  Molecular Pharmacology December 2000, 58 (6) 1525-1535; DOI: https://doi.org/10.1124/mol.58.6.1525
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  Activation of c-Jun N-Terminal Kinase and Activator Protein 1 by Receptor Activator of Nuclear Factor κB

  Zang Hee Lee, Kyubum Kwack, Kyung Keun Kim, Sang Ho Lee and Hong-Hee Kim

  Molecular Pharmacology December 2000, 58 (6) 1536-1545; DOI: https://doi.org/10.1124/mol.58.6.1536
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  Low Catecholamine Concentrations Protect Adult Rat Ventricular Myocytes against Apoptosis through cAMP-Dependent Extracellular Signal-Regulated Kinase Activation

  Morgana Henaff, Stéphane N. Hatem and Jean-Jacques Mercadier

  Molecular Pharmacology December 2000, 58 (6) 1546-1553; DOI: https://doi.org/10.1124/mol.58.6.1546
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  Correlative Association betweenN-Methyl-d-Aspartate Receptor-Mediated Expression of Period Genes in the Suprachiasmatic Nucleus and Phase Shifts in Behavior with Photic Entrainment of Clock in Hamsters

  Takahiro Moriya, Kazumasa Horikawa, Masashi Akiyama and Shigenobu Shibata

  Molecular Pharmacology December 2000, 58 (6) 1554-1562; DOI: https://doi.org/10.1124/mol.58.6.1554
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  Reversal of P-Glycoprotein and Multidrug-Resistance Protein-Mediated Drug Resistance in KB Cells by 5-O-Benzoylated Taxinine K

  Hiroshi Okumura, Zhe-Sheng Chen, Magoichi Sakou, Tomoyuki Sumizawa, Tatsuhiko Furukawa, Masaharu Komatsu, Ryuji Ikeda, Hikokazu Suzuki, Kosaku Hirota, Takashi Aikou and Shin-Ichi Akiyama

  Molecular Pharmacology December 2000, 58 (6) 1563-1569; DOI: https://doi.org/10.1124/mol.58.6.1563
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  Binding and Internalization of Fluorescent Opioid Peptide Conjugates in Living Cells

  Seksiri Arttamangkul, Veronica Alvarez-Maubecin, Gerald Thomas, John T. Williams and David K. Grandy

  Molecular Pharmacology December 2000, 58 (6) 1570-1580; DOI: https://doi.org/10.1124/mol.58.6.1570
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  Dopamine Transporter Tryptophan Mutants Highlight Candidate Dopamine- and Cocaine-Selective Domains

  Zhicheng Lin, Wenfei Wang and George R. Uhl

  Molecular Pharmacology December 2000, 58 (6) 1581-1592; DOI: https://doi.org/10.1124/mol.58.6.1581