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Molecular Pharmacology

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Table of Contents

December 01, 2000; Volume 58,Issue 6

Perspectives

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    Receptor Binding and Agonist Efficacy: New Insights from Mutants of the Thrombin Protease-Activated Receptor-1 (PAR-1)
    Morley D. Hollenberg
    Molecular Pharmacology December 2000, 58 (6) 1175-1177; DOI: https://doi.org/10.1124/mol.58.6.1175
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    Extracellular Mutations of Protease-Activated Receptor-1 Result in Differential Activation by Thrombin and Thrombin Receptor Agonist Peptide
    Brian D. Blackhart, Lily Ruslim-Litrus, Chin-Chun Lu, Veronica L. Alves, Willy Teng, Robert M. Scarborough, Elwood E. Reynolds and Donna Oksenberg
    Molecular Pharmacology December 2000, 58 (6) 1178-1187; DOI: https://doi.org/10.1124/mol.58.6.1178

MINIREVIEW

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    Lysophosphatidic Acid Receptors
    James J. A. Contos, Isao Ishii and Jerold Chun
    Molecular Pharmacology December 2000, 58 (6) 1188-1196; DOI: https://doi.org/10.1124/mol.58.6.1188

Articles

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    Normoxic Stabilization of Hypoxia-Inducible Factor-1 Expression and Activity: Redox-Dependent Effect of Nitrogen Oxides
    Lisa A. Palmer, Benjamin Gaston and Roger A. Johns
    Molecular Pharmacology December 2000, 58 (6) 1197-1203; DOI: https://doi.org/10.1124/mol.58.6.1197
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    Modulation of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Receptor Desensitization by Extracellular Protons
    Eva C. Ihle and Doris K. Patneau
    Molecular Pharmacology December 2000, 58 (6) 1204-1212; DOI: https://doi.org/10.1124/mol.58.6.1204
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    Tyrosine Phosphatase Inhibitors Selectively Antagonize β-Adrenergic Receptor-Dependent Regulation of Cardiac Ion Channels
    Carl Sims, Jason Chiu and Robert D. Harvey
    Molecular Pharmacology December 2000, 58 (6) 1213-1221; DOI: https://doi.org/10.1124/mol.58.6.1213
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    p53 Interacts with the DNA Mismatch Repair System to Modulate the Cytotoxicity and Mutagenicity of Hydrogen Peroxide
    Xinjian Lin, Krishna Ramamurthi, Misako Mishima, Akira Kondo and Stephen B. Howell
    Molecular Pharmacology December 2000, 58 (6) 1222-1229; DOI: https://doi.org/10.1124/mol.58.6.1222
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    The Use of Stimulus-Biased Assay Systems to Detect Agonist-Specific Receptor Active States: Implications for the Trafficking of Receptor Stimulus by Agonists
    Chris Watson, Grace Chen, Paul Irving, James Way, Wen-Ji Chen and Terry Kenakin
    Molecular Pharmacology December 2000, 58 (6) 1230-1238; DOI: https://doi.org/10.1124/mol.58.6.1230
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    Nuclear Factor I/CCAAT Box Transcription Factor trans-Activating Domain Is a Negative Sensor of Cellular Stress
    Yannick Morel, Xavier Coumoul, Antoine Nalpas and Robert Barouki
    Molecular Pharmacology December 2000, 58 (6) 1239-1246; DOI: https://doi.org/10.1124/mol.58.6.1239
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    Methamphetamine-Induced Neurotoxicity Is Attenuated in Transgenic Mice with a Null Mutation for Interleukin-6
    Bruce Ladenheim, Irina N. Krasnova, Xiaolin Deng, Jonathan M. Oyler, Aldo Polettini, Timothy H. Moran, Marilyn A. Huestis and Jean Lud Cadet
    Molecular Pharmacology December 2000, 58 (6) 1247-1256; DOI: https://doi.org/10.1124/mol.58.6.1247
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    Molecular and Functional Characterization of HSC54, a Novel Variant of Human Heat-Shock Cognate Protein 70
    Fujiko Tsukahara, Toshimasa Yoshioka and Takamura Muraki
    Molecular Pharmacology December 2000, 58 (6) 1257-1263; DOI: https://doi.org/10.1124/mol.58.6.1257
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    Molecular Determinants of Diltiazem Block in Domains IIIS6 and IVS6 of L-type Ca2+ Channels
    Gregory H. Hockerman, Nejmi Dilmac, Todd Scheuer and William A. Catterall
    Molecular Pharmacology December 2000, 58 (6) 1264-1270; DOI: https://doi.org/10.1124/mol.58.6.1264
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    Regulation of Central Synaptic Transmission by 5-HT1BAuto- and Heteroreceptors
    Hitoshi Morikawa, Olivier J. Manzoni, John C. Crabbe and John T. Williams
    Molecular Pharmacology December 2000, 58 (6) 1271-1278; DOI: https://doi.org/10.1124/mol.58.6.1271
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    Comparison of Agonist-Induced Internalization of the Human EP2 and EP4 Prostaglandin Receptors: Role of the Carboxyl Terminus in EP4 Receptor Sequestration
    Snehal Desai, Heather April, Chinwe Nwaneshiudu and Barrie Ashby
    Molecular Pharmacology December 2000, 58 (6) 1279-1286; DOI: https://doi.org/10.1124/mol.58.6.1279
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    Huanglian, A Chinese Herbal Extract, Inhibits Cell Growth by Suppressing the Expression of Cyclin B1 and Inhibiting CDC2 Kinase Activity in Human Cancer Cells
    Xiao-Kui Li, Monica Motwani, William Tong, William Bornmann and Gary K. Schwartz
    Molecular Pharmacology December 2000, 58 (6) 1287-1293; DOI: https://doi.org/10.1124/mol.58.6.1287
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    Nuclear Factor-κB Mediates Simultaneous Induction of Inducible Nitric-Oxide Synthase and Up-Regulation of the Cationic Amino Acid Transporter CAT-2B in Rat Alveolar Macrophages
    Rainer Hammermann, Maria Donata Messeri Dreißig, Jutta Mössner, Margarita Fuhrmann, Liberato Berrino, Manfred Göthert and Kurt Racké
    Molecular Pharmacology December 2000, 58 (6) 1294-1302; DOI: https://doi.org/10.1124/mol.58.6.1294
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    Differential Fibronectin Expression in Activated C6 Glial Cells Treated with Ethanol
    Li Q. Ren, Daniel K. Garrett, Marie Syapin and Peter J. Syapin
    Molecular Pharmacology December 2000, 58 (6) 1303-1309; DOI: https://doi.org/10.1124/mol.58.6.1303
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    Characterization of the Binding Site for a Novel Class of Noncompetitive α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Receptor Antagonists
    Frank S. Menniti, Bertrand L. Chenard, Mary B. Collins, Mary F. Ducat, Mark L. Elliott, Frank E. Ewing, Jianhua I. Huang, Kristin A. Kelly, John T. Lazzaro, Martin J. Pagnozzi, James L. Weeks, Willard M. Welch and W. Frost White
    Molecular Pharmacology December 2000, 58 (6) 1310-1317; DOI: https://doi.org/10.1124/mol.58.6.1310
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    Differential Response of KATP Channels Containing SUR2A or SUR2B Subunits to Nucleotides and Pinacidil
    Frank Reimann, Fiona M. Gribble and Frances M. Ashcroft
    Molecular Pharmacology December 2000, 58 (6) 1318-1325; DOI: https://doi.org/10.1124/mol.58.6.1318
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    Selective Abolishment of Pyrimidine Nucleoside Kinase Activity of Herpes Simplex Virus Type 1 Thymidine Kinase by Mutation of Alanine-167 to Tyrosine
    Bart Degrève, Robert Esnouf, Erik De Clercq and Jan Balzarini
    Molecular Pharmacology December 2000, 58 (6) 1326-1332; DOI: https://doi.org/10.1124/mol.58.6.1326
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    Decoy Oligodeoxynucleotide Characterization of Transcription Factors Controlling Endothelin-B Receptor Expression in Vascular Smooth Muscle Cells
    Andreas H. Wagner, Robert Krzesz, Dingcheng Gao, Christian Schroeder, Marco Cattaruzza and Markus Hecker
    Molecular Pharmacology December 2000, 58 (6) 1333-1340; DOI: https://doi.org/10.1124/mol.58.6.1333
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    Identification of Human Cytochrome P450s Involved in the Formation of All-trans-Retinoic Acid Principal Metabolites
    Julie Marill, Thierry Cresteil, Michel Lanotte and Guy G. Chabot
    Molecular Pharmacology December 2000, 58 (6) 1341-1348; DOI: https://doi.org/10.1124/mol.58.6.1341
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    Why Are A2B Receptors Low-Affinity Adenosine Receptors? Mutation of Asn273 to Tyr Increases Affinity of Human A2B Receptor for 2-(1-Hexynyl)adenosine
    Margot W. Beukers, Hans den Dulk, Erica W. van Tilburg, Jaap Brouwer and Adriaan P. Ijzerman
    Molecular Pharmacology December 2000, 58 (6) 1349-1356; DOI: https://doi.org/10.1124/mol.58.6.1349
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    Xenobiotic Transport across Isolated Brain Microvessels Studied by Confocal Microscopy
    David S. Miller, Stephanie N. Nobmann, Heike Gutmann, Michael Toeroek, Juergen Drewe and Gert Fricker
    Molecular Pharmacology December 2000, 58 (6) 1357-1367; DOI: https://doi.org/10.1124/mol.58.6.1357
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    2-Aminoethoxydiphenyl Borate Modulates Kinetics of Intracellular Ca2+ Signals Mediated by Inositol 1,4,5-Trisphosphate-Sensitive Ca2+ Stores in Single Pancreatic Acinar Cells of Mouse
    Jie Wu, Noritaka Kamimura, Teruko Takeo, Sechiko Suga, Makoto Wakui, Takayuki Maruyama and Katsuhiko Mikoshiba
    Molecular Pharmacology December 2000, 58 (6) 1368-1374; DOI: https://doi.org/10.1124/mol.58.6.1368
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    Correlation of the Apparent Affinities and Efficacies of γ-Aminobutyric AcidC Receptor Agonists
    Yongchang Chang, Douglas F. Covey and David S. Weiss
    Molecular Pharmacology December 2000, 58 (6) 1375-1380; DOI: https://doi.org/10.1124/mol.58.6.1375
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    The Third Intracellular Loop of the Rat and Mouse Cholecystokinin-A Receptors Is Responsible for Different Patterns of Gene Activation
    Roya Poosti, Laure di Malta, Didier Gagne, Nicole Bernad, Jean-Claude Galleyrand, Chantal Escrieut, Sandrine Silvente-Poirot, Daniel Fourmy and Jean Martinez
    Molecular Pharmacology December 2000, 58 (6) 1381-1388; DOI: https://doi.org/10.1124/mol.58.6.1381
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    Inhibition of Protein Isoprenylation Impairs Rho-Regulated Early Cellular Response to Genotoxic Stress
    Renate Gnad, Klaus Aktories, Bernd Kaina and Gerhard Fritz
    Molecular Pharmacology December 2000, 58 (6) 1389-1397; DOI: https://doi.org/10.1124/mol.58.6.1389
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    Induction of p27KIP1 as a Mechanism Underlying NS398-Induced Growth Inhibition in Human Lung Cancer Cells
    Wen-Chun Hung, Hui-Chiu Chang, Mei-Ren Pan, Te-Hsiu Lee and Lea-Yea Chuang
    Molecular Pharmacology December 2000, 58 (6) 1398-1403; DOI: https://doi.org/10.1124/mol.58.6.1398
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    Structural Domains of Chimeric Dopamine-Noradrenaline Human Transporters Involved in the Na+- and Cl−-Dependence of Dopamine Transport
    Maria Syringas, François Janin, Sana Mezghanni, Bruno Giros, Jean Costentin and Jean-Jacques Bonnet
    Molecular Pharmacology December 2000, 58 (6) 1404-1411; DOI: https://doi.org/10.1124/mol.58.6.1404
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    Modeling the Functional Effects of Allosteric Modulators at Pharmacological Receptors: An Extension of the Two-State Model of Receptor Activation
    David A. Hall
    Molecular Pharmacology December 2000, 58 (6) 1412-1423; DOI: https://doi.org/10.1124/mol.58.6.1412
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    Impaired Resensitization and Recycling of the Cholecystokinin Receptor by Co-expression of its Second Intracellular Loop
    Xi-Qin Ding, Rammohan V. Rao, Susan M. Kuntz, Eileen L. Holicky and Laurence J. Miller
    Molecular Pharmacology December 2000, 58 (6) 1424-1433; DOI: https://doi.org/10.1124/mol.58.6.1424
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    A Single Amino Acid Residue on the α5 Subunit (Ile215) Is Essential for Ligand Selectivity at α5β3γ2 γ-Aminobutyric AcidA Receptors
    Marina I. Strakhova, Scott C. Harvey, Christine M. Cook, James M. Cook and Phil Skolnick
    Molecular Pharmacology December 2000, 58 (6) 1434-1440; DOI: https://doi.org/10.1124/mol.58.6.1434
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    Dexamethasone Enhances Constitutive Androstane Receptor Expression in Human Hepatocytes: Consequences on Cytochrome P450 Gene Regulation
    Jean-Marc Pascussi, Sabine Gerbal-Chaloin, Jean-Michel Fabre, Patrick Maurel and Marie-José Vilarem
    Molecular Pharmacology December 2000, 58 (6) 1441-1450; DOI: https://doi.org/10.1124/mol.58.6.1441
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    Interactions of Alcuronium, TMB-8, and Other Allosteric Ligands with Muscarinic Acetylcholine Receptors: Studies with Chimeric Receptors
    John Ellis and Margaret Seidenberg
    Molecular Pharmacology December 2000, 58 (6) 1451-1460; DOI: https://doi.org/10.1124/mol.58.6.1451
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    Allosteric Inhibition of Endothelin ETA Receptors by 3,5-Dibromosalicylic Acid
    Virginie Blandin, Paul Vigne, Jean Philippe Breittmayer and Christian Frelin
    Molecular Pharmacology December 2000, 58 (6) 1461-1469; DOI: https://doi.org/10.1124/mol.58.6.1461
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    β-Adrenergic Stimulation of Rat Cardiac Fibroblasts Enhances Induction of Nitric-Oxide Synthase by Interleukin-1β via Message Stabilization
    Åsa B. Gustafsson and Laurence L. Brunton
    Molecular Pharmacology December 2000, 58 (6) 1470-1478; DOI: https://doi.org/10.1124/mol.58.6.1470
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    Protein Kinase Cα but not p44/42 Mitogen-Activated Protein Kinase, p38, or c-Jun NH2-Terminal Kinase Is Required for Intercellular Adhesion Molecule-1 Expression Mediated by Interleukin-1β: Involvement of Sequential Activation of Tyrosine Kinase, Nuclear Factor-κB-Inducing Kinase, and IκB Kinase 2
    Ching-Chow Chen, Jun-Jie Chen and Chian-Ying Chou
    Molecular Pharmacology December 2000, 58 (6) 1479-1489; DOI: https://doi.org/10.1124/mol.58.6.1479
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    Glycosylation of the Gastrin-Releasing Peptide Receptor and Its Effect on Expression, G Protein Coupling, and Receptor Modulatory Processes
    Richard V. Benya, Takashi Kusui, Tatsuro Katsuno, Takaharu Tsuda, Samuel A. Mantey, James F. Battey and Robert T. Jensen
    Molecular Pharmacology December 2000, 58 (6) 1490-1501; DOI: https://doi.org/10.1124/mol.58.6.1490
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    Competitive Antagonism of Recombinant P2X2/3Receptors by 2′,3′-O-(2,4,6-Trinitrophenyl) Adenosine 5′-Triphosphate (TNP-ATP)
    Edward C. Burgard, Wende Niforatos, Tim van Biesen, Kevin J. Lynch, Karen L. Kage, Edward Touma, Elizabeth A. Kowaluk and Michael F. Jarvis
    Molecular Pharmacology December 2000, 58 (6) 1502-1510; DOI: https://doi.org/10.1124/mol.58.6.1502
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    Synthetic Modification of Prostaglandin F2αIndicates Different Structural Determinants for Binding to the Prostaglandin F Receptor Versus the Prostaglandin Transporter
    Victor L. Schuster, Shigekazu Itoh, Steven W. Andrews, Robert M. Burk, June Chen, Karen M. Kedzie, Daniel W. Gil and David F. Woodward
    Molecular Pharmacology December 2000, 58 (6) 1511-1516; DOI: https://doi.org/10.1124/mol.58.6.1511
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    A Tetratricopeptide Repeat Half-Site in the Aryl Hydrocarbon Receptor Is Important for DNA Binding andtrans-Activation Potential
    Steven L. Levine, John R. Petrulis, Allison Dubil and Gary H. Perdew
    Molecular Pharmacology December 2000, 58 (6) 1517-1524; DOI: https://doi.org/10.1124/mol.58.6.1517
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    Replacement of an NH3 by an Iminoether in Transplatin Makes an Antitumor Drug from an Inactive Compound
    Marc Leng, Daniel Locker, Marie-Josèphe Giraud-Panis, Annie Schwartz, Francesco P. Intini, Giovanni Natile, Claudio Pisano, Angelina Boccarelli, Domenico Giordano and Mauro Coluccia
    Molecular Pharmacology December 2000, 58 (6) 1525-1535; DOI: https://doi.org/10.1124/mol.58.6.1525
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    Activation of c-Jun N-Terminal Kinase and Activator Protein 1 by Receptor Activator of Nuclear Factor κB
    Zang Hee Lee, Kyubum Kwack, Kyung Keun Kim, Sang Ho Lee and Hong-Hee Kim
    Molecular Pharmacology December 2000, 58 (6) 1536-1545; DOI: https://doi.org/10.1124/mol.58.6.1536
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    Low Catecholamine Concentrations Protect Adult Rat Ventricular Myocytes against Apoptosis through cAMP-Dependent Extracellular Signal-Regulated Kinase Activation
    Morgana Henaff, Stéphane N. Hatem and Jean-Jacques Mercadier
    Molecular Pharmacology December 2000, 58 (6) 1546-1553; DOI: https://doi.org/10.1124/mol.58.6.1546
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    Correlative Association betweenN-Methyl-d-Aspartate Receptor-Mediated Expression of Period Genes in the Suprachiasmatic Nucleus and Phase Shifts in Behavior with Photic Entrainment of Clock in Hamsters
    Takahiro Moriya, Kazumasa Horikawa, Masashi Akiyama and Shigenobu Shibata
    Molecular Pharmacology December 2000, 58 (6) 1554-1562; DOI: https://doi.org/10.1124/mol.58.6.1554
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    Reversal of P-Glycoprotein and Multidrug-Resistance Protein-Mediated Drug Resistance in KB Cells by 5-O-Benzoylated Taxinine K
    Hiroshi Okumura, Zhe-Sheng Chen, Magoichi Sakou, Tomoyuki Sumizawa, Tatsuhiko Furukawa, Masaharu Komatsu, Ryuji Ikeda, Hikokazu Suzuki, Kosaku Hirota, Takashi Aikou and Shin-Ichi Akiyama
    Molecular Pharmacology December 2000, 58 (6) 1563-1569; DOI: https://doi.org/10.1124/mol.58.6.1563
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    Binding and Internalization of Fluorescent Opioid Peptide Conjugates in Living Cells
    Seksiri Arttamangkul, Veronica Alvarez-Maubecin, Gerald Thomas, John T. Williams and David K. Grandy
    Molecular Pharmacology December 2000, 58 (6) 1570-1580; DOI: https://doi.org/10.1124/mol.58.6.1570
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    Dopamine Transporter Tryptophan Mutants Highlight Candidate Dopamine- and Cocaine-Selective Domains
    Zhicheng Lin, Wenfei Wang and George R. Uhl
    Molecular Pharmacology December 2000, 58 (6) 1581-1592; DOI: https://doi.org/10.1124/mol.58.6.1581

Accelerated Communications

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    Expression Profiling of Neural Cells Reveals Specific Patterns of Ethanol-Responsive Gene Expression
    Christelle Thibault, Chaoqiang Lai, Norbert Wilke, Bao Duong, M. Foster Olive, Sajida Rahman, Helin Dong, Clyde W. Hodge, David J. Lockhart and Michael F. Miles
    Molecular Pharmacology December 2000, 58 (6) 1593-1600; DOI: https://doi.org/10.1124/mol.58.6.1593
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    Molecular Cloning and Characterization of a Second Human Cysteinyl Leukotriene Receptor: Discovery of a Subtype Selective Agonist
    Hans-Peter Nothacker, Zhiwei Wang, Yuhong Zhu, Rainer K. Reinscheid, Steven H. S. Lin and Olivier Civelli
    Molecular Pharmacology December 2000, 58 (6) 1601-1608; DOI: https://doi.org/10.1124/mol.58.6.1601
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    Importance of Histidine Residues for the Function of the Human Liver UDP-Glucuronosyltransferase UGT1A6: Evidence for the Catalytic Role of Histidine 370
    Mohamed Ouzzine, Laurence Antonio, Brian Burchell, Patrick Netter, Sylvie Fournel-Gigleux and Jacques Magdalou
    Molecular Pharmacology December 2000, 58 (6) 1609-1615; DOI: https://doi.org/10.1124/mol.58.6.1609
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Molecular Pharmacology: 58 (6)
Molecular Pharmacology
Vol. 58, Issue 6
1 Dec 2000
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