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Research ArticleArticle

Selective Abolishment of Pyrimidine Nucleoside Kinase Activity of Herpes Simplex Virus Type 1 Thymidine Kinase by Mutation of Alanine-167 to Tyrosine

Bart Degrève, Robert Esnouf, Erik De Clercq and Jan Balzarini
Molecular Pharmacology December 2000, 58 (6) 1326-1332; DOI: https://doi.org/10.1124/mol.58.6.1326
Bart Degrève
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Robert Esnouf
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Erik De Clercq
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Jan Balzarini
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Article Information

vol. 58 no. 6 1326-1332
DOI 
https://doi.org/10.1124/mol.58.6.1326
PubMed 
11093770

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received June 12, 2000
  • Accepted September 7, 2000
  • Published online December 1, 2000.

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Bart Degrève1,
  2. Robert Esnouf2,
  3. Erik De Clercq1, and
  4. Jan Balzarini1
  1. 1Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Leuven, Belgium (B.D., E.D.C., J.B.); and 2Division of Structural Biology, Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom (R.E.)
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Molecular Pharmacology: 58 (6)
Molecular Pharmacology
Vol. 58, Issue 6
1 Dec 2000
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Research ArticleArticle

Selective Abolishment of Pyrimidine Nucleoside Kinase Activity of Herpes Simplex Virus Type 1 Thymidine Kinase by Mutation of Alanine-167 to Tyrosine

Bart Degrève, Robert Esnouf, Erik De Clercq and Jan Balzarini
Molecular Pharmacology December 1, 2000, 58 (6) 1326-1332; DOI: https://doi.org/10.1124/mol.58.6.1326

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Research ArticleArticle

Selective Abolishment of Pyrimidine Nucleoside Kinase Activity of Herpes Simplex Virus Type 1 Thymidine Kinase by Mutation of Alanine-167 to Tyrosine

Bart Degrève, Robert Esnouf, Erik De Clercq and Jan Balzarini
Molecular Pharmacology December 1, 2000, 58 (6) 1326-1332; DOI: https://doi.org/10.1124/mol.58.6.1326
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