Table of Contents

Articles

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  A Novel Approach to Thymidylate Synthase as a Target for Cancer Chemotherapy

  Qing Li, Christopher Boyer, Jean Y. Lee and H. Michael Shepard

  Molecular Pharmacology March 2001, 59 (3) 446-452; DOI: https://doi.org/10.1124/mol.59.3.446
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  The Catalytic DNA Topoisomerase II Inhibitor Dexrazoxane (ICRF-187) Induces Differentiation and Apoptosis in Human Leukemia K562 Cells

  Brian B. Hasinoff, Michael E. Abram, Norman Barnabé, Tayeb Khélifa, William P. Allan and Jack C. Yalowich

  Molecular Pharmacology March 2001, 59 (3) 453-461; DOI: https://doi.org/10.1124/mol.59.3.453
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  Dolastatin 11, a Marine Depsipeptide, Arrests Cells at Cytokinesis and Induces Hyperpolymerization of Purified Actin

  Ruoli Bai, Pascal Verdier-Pinard, Sanjeev Gangwar, Chad C. Stessman, Kelly J. McClure, Edward A. Sausville, George R. Pettit, Robert B. Bates and Ernest Hamel

  Molecular Pharmacology March 2001, 59 (3) 462-469; DOI: https://doi.org/10.1124/mol.59.3.462
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  Two Nuclear Proteins, Cin5 and Ydr259c, Confer Resistance to Cisplatin in Saccharomyces cerevisiae

  Takemitsu Furuchi, Hirohide Ishikawa, Nobuhiko Miura, Miki Ishizuka, Kazuki Kajiya, Shusuke Kuge and Akira Naganuma

  Molecular Pharmacology March 2001, 59 (3) 470-474; DOI: https://doi.org/10.1124/mol.59.3.470
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  Amino Acid Residues Critical for Differential Inhibition of CYP2B4, CYP2B5, and CYP2B1 by Phenylimidazoles

  Margit Spatzenegger, Qinmi Wang, You Qun He, Michael R. Wester, Eric F. Johnson and James R. Halpert

  Molecular Pharmacology March 2001, 59 (3) 475-484; DOI: https://doi.org/10.1124/mol.59.3.475
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  Inhibition of Corticotropin Releasing Hormone Type-1 Receptor Translation by an Upstream AUG Triplet in the 5′ Untranslated Region

  Guoheng Xu, Cristina Rabadan-Diehl, Maria Nikodemova, Peter Wynn, Joachim Spiess and Greti Aguilera

  Molecular Pharmacology March 2001, 59 (3) 485-492; DOI: https://doi.org/10.1124/mol.59.3.485
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  Tumor Necrosis Factor-α-Induced Cyclooxygenase-2 Expression via Sequential Activation of Ceramide-Dependent Mitogen-Activated Protein Kinases, and IκB Kinase 1/2 in Human Alveolar Epithelial Cells

  Ching-Chow Chen, Yi-Tao Sun, Jun-Jie Chen and Ya-Jen Chang

  Molecular Pharmacology March 2001, 59 (3) 493-500; DOI: https://doi.org/10.1124/mol.59.3.493
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  A Typical Y1 Receptor Regulates Feeding Behaviors: Effects of a Potent and Selective Y1 Antagonist, J-115814

  Akio Kanatani, Mikiko Hata, Satoshi Mashiko, Akane Ishihara, Osamu Okamoto, Yuji Haga, Tomoyuki Ohe, Tetsuya Kanno, Naomi Murai, Yasuyuki Ishii, Takahiro Fukuroda, Takehiro Fukami and Masaki Ihara

  Molecular Pharmacology March 2001, 59 (3) 501-505; DOI: https://doi.org/10.1124/mol.59.3.501
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  A Bioactive Metabolite of Benzo[a]pyrene, Benzo[a]pyrene-7,8-dione, Selectively Alters Microsomal Ca²⁺ Transport and Ryanodine Receptor Function

  Isaac N. Pessah, Chris Beltzner, Scott W. Burchiel, Gopishetty Sridhar, Trevor Penning and Wei Feng

  Molecular Pharmacology March 2001, 59 (3) 506-513; DOI: https://doi.org/10.1124/mol.59.3.506
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  Interactions of Tryptamine Derivatives with Serotonin Transporter Species Variants Implicate Transmembrane Domain I in Substrate Recognition

  Erika M. Adkins, Eric L. Barker and Randy D. Blakely

  Molecular Pharmacology March 2001, 59 (3) 514-523; DOI: https://doi.org/10.1124/mol.59.3.514
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  Structural Domains Influencing Sensitivity to Isothiourea Derivative Inhibitor KB-R7943 in Cardiac Na⁺/Ca²⁺ Exchanger

  Takahiro Iwamoto, Satomi Kita, Akira Uehara, Yutaka Inoue, Yuki Taniguchi, Issei Imanaga and Munekazu Shigekawa

  Molecular Pharmacology March 2001, 59 (3) 524-531; DOI: https://doi.org/10.1124/mol.59.3.524
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  Inverse Agonist Activity at the α_2A-Adrenergic Receptor

  Susan M. Wade, Keng-Li Lan, Dorian J. Moore and Richard R. Neubig

  Molecular Pharmacology March 2001, 59 (3) 532-542; DOI: https://doi.org/10.1124/mol.59.3.532
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  Short- and Long-Term Functional Alterations of the Skeletal Muscle Calcium Release Channel (Ryanodine Receptor) by Suramin: Apparent Dissociation of Single Channel Current Recording and [³H]Ryanodine Binding

  Josef Suko, Gertrude Hellmann and Helmut Drobny

  Molecular Pharmacology March 2001, 59 (3) 543-556; DOI: https://doi.org/10.1124/mol.59.3.543
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  Aryl Hydrocarbon Receptor (AhR)/AhR Nuclear Translocator (ARNT) Activity Is Unaltered by Phosphorylation of a Periodicity/ARNT/Single-Minded (PAS)-Region Serine Residue

  Steven L. Levine and Gary H. Perdew

  Molecular Pharmacology March 2001, 59 (3) 557-566; DOI: https://doi.org/10.1124/mol.59.3.557
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  The Transcription Factor Fos-Related Antigen 1 Is Induced by Thiazolidinediones During Differentiation of 3T3-L1 Cells

  Tatjana Albrektsen and Jan Fleckner

  Molecular Pharmacology March 2001, 59 (3) 567-575; DOI: https://doi.org/10.1124/mol.59.3.567
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  Angiotensin AT₁ Receptor Phosphorylation and Desensitization in a Hepatic Cell Line. Roles of Protein Kinase C and Phosphoinositide 3-Kinase

  Agustı́n Garcı́a-Caballero, J. Alberto Olivares-Reyes, Kevin J. Catt and J. Adolfo Garcı́a-Saı́nz

  Molecular Pharmacology March 2001, 59 (3) 576-585; DOI: https://doi.org/10.1124/mol.59.3.576
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  Uptake of Pentamidine in Trypanosoma brucei bruceiis Mediated by Three Distinct Transporters: Implications for Cross-Resistance with Arsenicals

  Harry P. De Koning

  Molecular Pharmacology March 2001, 59 (3) 586-592; DOI: https://doi.org/10.1124/mol.59.3.586
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  Disruption of Cell Adhesion and Caspase-Mediated Proteolysis of β- and γ-Catenins and APC Protein in Paclitaxel-Induced Apoptosis

  Yi-He Ling, Yun Zhong and Roman Perez-Soler

  Molecular Pharmacology March 2001, 59 (3) 593-603; DOI: https://doi.org/10.1124/mol.59.3.593
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  Selective Enhancement of L-Type Calcium Currents by Corticotropin in Acutely Isolated Rat Amygdala Neurons

  Chainllie Young, Ya-Chun Huang, Chih-Hung Lin, Yu-Zen Shen and Po-Wu Gean

  Molecular Pharmacology March 2001, 59 (3) 604-611; DOI: https://doi.org/10.1124/mol.59.3.604
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  Modulation of Synaptic Transmission by Nociceptin/Orphanin FQ and Nocistatin in the Spinal Cord Dorsal Horn of Mutant Mice Lacking the Nociceptin/Orphanin FQ Receptor

  Seifollah Ahmadi, Carolin Kotalla, Hans Gühring, Hiroshi Takeshima, Andreas Pahl and Hanns Ulrich Zeilhofer

  Molecular Pharmacology March 2001, 59 (3) 612-618; DOI: https://doi.org/10.1124/mol.59.3.612
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  Characterization of Recombinant, Soluble β-Secretase from an Insect Cell Expression System

  William D. Mallender, Debra Yager, Luisa Onstead, Michael R. Nichols, Christopher Eckman, Kumar Sambamurti, Lisa M. Kopcho, Jovita Marcinkeviciene, Robert A. Copeland and Terrone L. Rosenberry

  Molecular Pharmacology March 2001, 59 (3) 619-626; DOI: https://doi.org/10.1124/mol.59.3.619
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  Cholestatic Potential of Troglitazone as a Possible Factor Contributing to Troglitazone-Induced Hepatotoxicity: In Vivo and in Vitro Interaction at the Canalicular Bile Salt Export Pump (Bsep) in the Rat

  Christoph Funk, Christiane Ponelle, Gerd Scheuermann and Michael Pantze

  Molecular Pharmacology March 2001, 59 (3) 627-635; DOI: https://doi.org/10.1124/mol.59.3.627
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  Glucuronidation of the Nonsteroidal Antiestrogen EM-652 (SCH 57068), by Human and Monkey Steroid Conjugating UDP-Glucuronosyltransferase Enzymes

  Olivier Barbier, Caroline Albert, Isabelle Martineau, Michel Vallée, Kim High, Fernand Labrie, Dean W. Hum, Claude Labrie and Alain Bélanger

  Molecular Pharmacology March 2001, 59 (3) 636-645; DOI: https://doi.org/10.1124/mol.59.3.636
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  Inhibition of Geranylgeranylation Reduces Angiotensin II-Mediated Free Radical Production in Vascular Smooth Muscle Cells: Involvement of Angiotensin AT1 Receptor Expression and Rac1 GTPase

  Sven Wassmann, Ulrich Laufs, Anselm T. Bäumer, Kirsten Müller, Christian Konkol, Heinrich Sauer, Michael Böhm and Georg Nickenig

  Molecular Pharmacology March 2001, 59 (3) 646-654; DOI: https://doi.org/10.1124/mol.59.3.646