Cover Caption
About the cover: Molecular modeling and site-directed mutagenesis reveal differential binding of α-methyl 5HT to the 5-HT2A receptor. Views (from the extracellular side of the receptor) of the transmembrane helices (represented as tubes), showing various agonists (green) and all residues within a 3.5-Å sphere radius of the agonist molecule in energy-minimized complexes after 100-ps molecular dynamics simulations. The top two panels show the simulated binding of 5-methyl-DMT and N-ω-methyl-5HT. The bottom two panels show two views of the simulated binding of α-Me-5HT to the 5-HT2A receptor after two different molecular dynamics simulations (see Results and Discussion for details). Color coding of ligand and receptor atoms: red, O; green, N; cyan, H; white, C in the receptor; green: C in the ligand. Mol Pharmacol 58:877–886.
