Table of Contents

Articles

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  Increased Bioavailability of the Food-Derived Carcinogen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in MRP2-Deficient Rats

  Christoph G. Dietrich, D. Rudi de Waart, Roel Ottenhoff, Ivo G. Schoots and Ronald P. J. Oude Elferink

  Molecular Pharmacology May 2001, 59 (5) 974-980; DOI: https://doi.org/10.1124/mol.59.5.974
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  Zn²⁺ Induces Stimulation of the c-Jun N-Terminal Kinase Signaling Pathway through Phosphoinositide 3-Kinase

  Soo-Jung Eom, Eun Young Kim, Ji Eun Lee, Hyo Jung Kang, Jaekyung Shim, Seong Up Kim, Byoung Joo Gwag and Eui-Ju Choi

  Molecular Pharmacology May 2001, 59 (5) 981-986; DOI: https://doi.org/10.1124/mol.59.5.981
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  Transcriptional Induction of Hepatic NADPH: Cytochrome P450 Oxidoreductase by Thyroid Hormone

  Huan-Chen Li, Dongxu Liu and David J. Waxman

  Molecular Pharmacology May 2001, 59 (5) 987-995; DOI: https://doi.org/10.1124/mol.59.5.987
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  Molecular Cloning, Genomic Positioning, Promoter Identification, and Characterization of the Novel Cyclic AMP-Specific Phosphodiesterase PDE4A10

  Graham Rena, Fiona Begg, Annette Ross, Carolynn MacKenzie, Ian McPhee, Lachlan Campbell, Elaine Huston, Michael Sullivan and Miles D. Houslay

  Molecular Pharmacology May 2001, 59 (5) 996-1011; DOI: https://doi.org/10.1124/mol.59.5.996
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  Role of Protein Kinase Cα in Signaling from the Histamine H₁ Receptor to the Nucleus

  A. C. Megson, E. M. Walker and S. J. Hill

  Molecular Pharmacology May 2001, 59 (5) 1012-1021; DOI: https://doi.org/10.1124/mol.59.5.1012
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  Mutational Analysis of the Functional Role of Conserved Arginine and Lysine Residues in Transmembrane Domains of the Murine Reduced Folate Carrier

  Iraida G. Sharina, Rongbao Zhao, Yanhua Wang, Solomon Babani and I. David Goldman

  Molecular Pharmacology May 2001, 59 (5) 1022-1028; DOI: https://doi.org/10.1124/mol.59.5.1022
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  Expression of Multiple Subtypes of Muscarinic Receptors and Cellular Distribution in the Human Heart

  Huizhen Wang, Hong Han, Liming Zhang, Hong Shi, Gernot Schram, Stanley Nattel and Zhiguo Wang

  Molecular Pharmacology May 2001, 59 (5) 1029-1036; DOI: https://doi.org/10.1124/mol.59.5.1029
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  Characterization of Glutamate-Gated Chloride Channels in the Pharynx of Wild-Type and Mutant Caenorhabditis elegansDelineates the Role of the Subunit GluCl-α2 in the Function of the Native Receptor

  Darrel J. Pemberton, Christopher J. Franks, Robert J. Walker and Lindy Holden-Dye

  Molecular Pharmacology May 2001, 59 (5) 1037-1043; DOI: https://doi.org/10.1124/mol.59.5.1037
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  Antimitogenic Actions of Organic Nitrates Are Potentiated by Sildenafil and Mediated Via Activation of Protein Kinase A

  Michael T. Osinski, Bernhard H. Rauch and Karsten Schrör

  Molecular Pharmacology May 2001, 59 (5) 1044-1050; DOI: https://doi.org/10.1124/mol.59.5.1044
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  Characterization of the Dizocilpine Binding Site on the Nicotinic Acetylcholine Receptor

  Hugo R. Arias, Elizabeth A. McCardy and Michael P. Blanton

  Molecular Pharmacology May 2001, 59 (5) 1051-1060; DOI: https://doi.org/10.1124/mol.59.5.1051
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  Direct Activation of an Inwardly Rectifying Potassium Channel by Arachidonic Acid

  Yi Liu, Dong Liu, Louise Heath, Diane M. Meyers, Douglas S. Krafte, P. Kay Wagoner, Christopher P. Silvia, Weifeng Yu and Mark E. Curran

  Molecular Pharmacology May 2001, 59 (5) 1061-1068; DOI: https://doi.org/10.1124/mol.59.5.1061
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  Cocaine Blocks HERG, but Not KvLQT1+minK, Potassium Channels

  Shetuan Zhang, Sridharan Rajamani, Yuenmu Chen, Qiuming Gong, Yajing Rong, Zhengfeng Zhou, Arnold Ruoho and Craig T. January

  Molecular Pharmacology May 2001, 59 (5) 1069-1076; DOI: https://doi.org/10.1124/mol.59.5.1069
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  Charged Amino Acids in the Transmembrane Domains Are Involved in the Determination of the Substrate Specificity of Rat Mrp2

  Kousei Ito, Hiroshi Suzuki and Yuichi Sugiyama

  Molecular Pharmacology May 2001, 59 (5) 1077-1085; DOI: https://doi.org/10.1124/mol.59.5.1077
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  Phospholipids as Modulators of K_ATP Channels: Distinct Mechanisms for Control of Sensitivity to Sulphonylureas, K⁺ Channel Openers, and ATP

  Tobias Krauter, J. Peter Ruppersberg and Thomas Baukrowitz

  Molecular Pharmacology May 2001, 59 (5) 1086-1093; DOI: https://doi.org/10.1124/mol.59.5.1086
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  The Novel Triterpenoid CDDO Induces Apoptosis and Differentiation of Human Osteosarcoma Cells by a Caspase-8 Dependent Mechanism

  Yasumasa Ito, Pramod Pandey, Michael B. Sporn, Rakesh Datta, Surender Kharbanda and Donald Kufe

  Molecular Pharmacology May 2001, 59 (5) 1094-1099; DOI: https://doi.org/10.1124/mol.59.5.1094
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  Disparate Role of Na⁺ Channel D2-S6 Residues in Batrachotoxin and Local Anesthetic Action

  Sho-Ya Wang, Maria Barile and Ging Kuo Wang

  Molecular Pharmacology May 2001, 59 (5) 1100-1107; DOI: https://doi.org/10.1124/mol.59.5.1100
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  Effect of α Subunit on Allosteric Modulation of Ion Channel Function in Stably Expressed Human Recombinant γ-Aminobutyric Acid_A Receptors Determined Using³⁶Cl Ion Flux

  Alison J. Smith, Luanda Alder, Jonathan Silk, Charles Adkins, Alan E. Fletcher, Tim Scales, Julie Kerby, George Marshall, Keith A. Wafford, Ruth M. McKernan and John R. Atack

  Molecular Pharmacology May 2001, 59 (5) 1108-1118; DOI: https://doi.org/10.1124/mol.59.5.1108
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  High-Intensity p38 Kinase Activity Is Critical for p21 ^cip1 Induction and the Antiproliferative Function of G_i Protein-Coupled Receptors

  Forbes Alderton, Patrick P. A. Humphrey and Lynda A. Sellers

  Molecular Pharmacology May 2001, 59 (5) 1119-1128; DOI: https://doi.org/10.1124/mol.59.5.1119
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  Quantitative Analysis of Inward and Outward Transport Rates in Cells Stably Expressing the Cloned Human Serotonin Transporter: Inconsistencies with the Hypothesis of Facilitated Exchange Diffusion

  Harald H. Sitte, Birgit Hiptmair, Julia Zwach, Christian Pifl, Ernst A. Singer and Petra Scholze

  Molecular Pharmacology May 2001, 59 (5) 1129-1137; DOI: https://doi.org/10.1124/mol.59.5.1129
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  PI3K Inhibitors Reverse the Suppressive Actions of Insulin on CYP2E1 Expression by Activating Stress-Response Pathways in Primary Rat Hepatocytes

  Jaspreet S. Sidhu, Fei Liu, Sean M. Boyle and Curtis J. Omiecinski

  Molecular Pharmacology May 2001, 59 (5) 1138-1146; DOI: https://doi.org/10.1124/mol.59.5.1138
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  Activation of Phosphatidylinositol 3-Kinase and Akt bytert-Butylhydroquinone Is Responsible for Antioxidant Response Element-Mediated rGSTA2 Induction in H4IIE Cells

  Keon Wook Kang, Min Kyung Cho, Chang Ho Lee and Sang Geon Kim

  Molecular Pharmacology May 2001, 59 (5) 1147-1156; DOI: https://doi.org/10.1124/mol.59.5.1147
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  Dual Incorporation of Photoaffinity Ligands on Dopamine Transporters Implicates Proximity of Labeled Domains

  Roxanne A. Vaughan, Jon D. Gaffaney, John R. Lever, Maarten E. A. Reith and Aloke K. Dutta

  Molecular Pharmacology May 2001, 59 (5) 1157-1164; DOI: https://doi.org/10.1124/mol.59.5.1157
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  Involvement of Nuclear Factor κB in c-Myc Induction by Tubulin Polymerization Inhibitors

  V. Bourgarel-Rey, S. Vallee, O. Rimet, S. Champion, D. Braguer, A. Desobry, C. Briand and Y. Barra

  Molecular Pharmacology May 2001, 59 (5) 1165-1170; DOI: https://doi.org/10.1124/mol.59.5.1165
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  Modulation of Multidrug Resistance Protein 1 (MRP1/ABCC1) Transport and ATPase Activities by Interaction with Dietary Flavonoids

  Elaine M. Leslie, Qingcheng Mao, Curtis J. Oleschuk, Roger G. Deeley and Susan P. C. Cole

  Molecular Pharmacology May 2001, 59 (5) 1171-1180; DOI: https://doi.org/10.1124/mol.59.5.1171
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  Phosphorylation of Uridine and Cytidine Nucleoside Analogs by Two Human Uridine-Cytidine Kinases

  An R. Van Rompay, Ameli Norda, Karin Lindén, Magnus Johansson and Anna Karlsson

  Molecular Pharmacology May 2001, 59 (5) 1181-1186; DOI: https://doi.org/10.1124/mol.59.5.1181
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  Determination of Amino Acid Residues that are Accessible from the Ligand Binding Crevice in the Seventh Transmembrane-Spanning Region of the Human A₁ Adenosine Receptor

  Eric S. Dawson and Jack N. Wells

  Molecular Pharmacology May 2001, 59 (5) 1187-1195; DOI: https://doi.org/10.1124/mol.59.5.1187
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  Tripterygium wilfordii Hook F Extract Suppresses Proinflammatory Cytokine-Induced Expression of Matrix Metalloproteinase Genes in Articular Chondrocytes by Inhibiting Activating Protein-1 and Nuclear Factor-κB Activities

  Judith Sylvester, Abdelhamid Liacini, Wen Qing Li, Faramaze Dehnade and Muhammad Zafarullah

  Molecular Pharmacology May 2001, 59 (5) 1196-1205; DOI: https://doi.org/10.1124/mol.59.5.1196
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  Structural Determinants of Adenophostin A Activity at Inositol Trisphosphate Receptors

  Vanessa Correa, Andrew M. Riley, Satoshi Shuto, Graeme Horne, Edmund P. Nerou, Rachel D. Marwood, Barry V. L. Potter and Colin W. Taylor

  Molecular Pharmacology May 2001, 59 (5) 1206-1215; DOI: https://doi.org/10.1124/mol.59.5.1206
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  Mitogen-Activated Protein Kinase Kinase Inhibitor PD98059 Blocks the trans-Activation but Not the Stabilization or DNA Binding Ability of Hypoxia-Inducible Factor-1α

  Eunseon Hur, Keun Young Chang, Eunjung Lee, Seung-Ki Lee and Hyunsung Park

  Molecular Pharmacology May 2001, 59 (5) 1216-1224; DOI: https://doi.org/10.1124/mol.59.5.1216
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  Cloning and Characterization of the Mouse α1C/A-Adrenergic Receptor Gene and Analysis of an α1C Promoter in Cardiac Myocytes: Role of an MCAT Element That Binds Transcriptional Enhancer Factor-1 (TEF-1)

  Timothy D. O'Connell, D. Gregg Rokosh and Paul C. Simpson

  Molecular Pharmacology May 2001, 59 (5) 1225-1234; DOI: https://doi.org/10.1124/mol.59.5.1225
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  Use of Antisense Oligonucleotides to Verify the Role of the α_1A-Adrenergic Receptor in the Contractility of the Rat Uterus Post Partum

  E. Ducza, R. Gáspár, A. Márki, P. Gyula, S. Bottka and G. Falkay

  Molecular Pharmacology May 2001, 59 (5) 1235-1242; DOI: https://doi.org/10.1124/mol.59.5.1235
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  Calcium Channel α₂δ Subunits—Structure and Gabapentin Binding

  Elsé Marais, Norbert Klugbauer and Franz Hofmann

  Molecular Pharmacology May 2001, 59 (5) 1243-1248; DOI: https://doi.org/10.1124/mol.59.5.1243
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  Synthetic Phytoceramides Induce Apoptosis with Higher Potency than Ceramides

  Onyou Hwang, Guncheol Kim, Yeon Joo Jang, Seong Who Kim, Guiyong Choi, Hyun Jin Choi, Seon Young Jeon, Don Gyu Lee and Jae Dam Lee

  Molecular Pharmacology May 2001, 59 (5) 1249-1255; DOI: https://doi.org/10.1124/mol.59.5.1249
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  Agonist-Dependent Delivery of M₂ Muscarinic Acetylcholine Receptors to the Cell Surface after Pertussis Toxin Treatment

  Aaron G. Roseberry, Moritz Bünemann, Jyoti Elavunkal and M. Marlene Hosey

  Molecular Pharmacology May 2001, 59 (5) 1256-1268; DOI: https://doi.org/10.1124/mol.59.5.1256
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  Induction of Differentiation in F9 Cells and Activation of Peroxisome Proliferator-Activated Receptor δ by Valproic Acid and Its Teratogenic Derivatives

  Uwe Werling, Sandra Siehler, Margarethe Litfin, Heinz Nau and Martin Göttlicher

  Molecular Pharmacology May 2001, 59 (5) 1269-1276; DOI: https://doi.org/10.1124/mol.59.5.1269
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  Identification and Characterization of Human Organic Anion Transporter 3 Expressing Predominantly in the Kidney

  Seok Ho Cha, Takashi Sekine, Jun-ichi Fukushima, Yoshikatsu Kanai, Yukari Kobayashi, Tomoyuki Goya and Hitoshi Endou

  Molecular Pharmacology May 2001, 59 (5) 1277-1286; DOI: https://doi.org/10.1124/mol.59.5.1277
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  Scabronine G-Methylester Enhances Secretion of Neurotrophic Factors Mediated by an Activation of Protein Kinase C-ζ

  Yutaro Obara, Hironori Kobayashi, Tomihisa Ohta, Yasushi Ohizumi and Norimichi Nakahata

  Molecular Pharmacology May 2001, 59 (5) 1287-1297; DOI: https://doi.org/10.1124/mol.59.5.1287
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  Diamidine Compounds: Selective Uptake and Targeting inPlasmodium falciparum

  Andrew M. W. Stead, Patrick G. Bray, I. Geoffrey Edwards, Harry P. DeKoning, Barry C. Elford, Paul A. Stocks and Stephen A. Ward

  Molecular Pharmacology May 2001, 59 (5) 1298-1306; DOI: https://doi.org/10.1124/mol.59.5.1298
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  Antimineralocorticoid 11β-Substituted Spirolactones Exhibit Androgen Receptor Agonistic Activity: A Structure Function Study

  Philippe Nirdé, Béatrice Térouanne, Nadine Gallais, Charles Sultan and Gilles Auzou

  Molecular Pharmacology May 2001, 59 (5) 1307-1313; DOI: https://doi.org/10.1124/mol.59.5.1307
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  Involvement of Caveolin in Ligand-Induced Recruitment and Internalization of A₁ Adenosine Receptor and Adenosine Deaminase in an Epithelial Cell Line

  Silvia Ginés, Franciso Ciruela, Javier Burgueño, Vicent Casadó, Enric. I. Canela, Josefa Mallol, Carme Lluı́s and Rafael Franco

  Molecular Pharmacology May 2001, 59 (5) 1314-1323; DOI: https://doi.org/10.1124/mol.59.5.1314
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  Carboxypeptidase D Is Up-Regulated in RAW 264.7 Macrophages and Stimulates Nitric Oxide Synthesis by Cells in Arginine-Free Medium

  Vaishali Hadkar and Randal A. Skidgel

  Molecular Pharmacology May 2001, 59 (5) 1324-1332; DOI: https://doi.org/10.1124/mol.59.5.1324
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  Rhodostomin, A Snake Venom Disintegrin, Inhibits Angiogenesis Elicited by Basic Fibroblast Growth Factor and Suppresses Tumor Growth by A Selective α_vβ₃ Blockade of Endothelial Cells

  Chia-Hsin Yeh, Hui-Chin Peng, Rong-Seng Yang and Tur-Fu Huang

  Molecular Pharmacology May 2001, 59 (5) 1333-1342; DOI: https://doi.org/10.1124/mol.59.5.1333
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  Molecular Mechanism for Agonist-Promoted α_2A-Adrenoceptor Activation by Norepinephrine and Epinephrine

  Tommi Nyrönen, Marjo Pihlavisto, Juha M. Peltonen, Anna-Marja Hoffrén, Minna Varis, Tiina Salminen, Siegfried Wurster, Anne Marjamäki, Liisa Kanerva, Erja Katainen, Leif Laaksonen, Juha-Matti Savola, Mika Scheinin and Mark S. Johnson

  Molecular Pharmacology May 2001, 59 (5) 1343-1354; DOI: https://doi.org/10.1124/mol.59.5.1343