Abstract
The heliotridine-based pyrrolizidine alkaloids lasiocarpine and heliotrine were metabolized in vitro by rat liver microsomes to one main chloroform-extractable and water-soluble pyrrolic derivative, which was isolated and idenitified as dehydroheliotridine (6,7-dihydro-7α-hydroxy-1-hydroxymethyl-5H-pyrrolizine) by chromatography and nuclear magnetic resonance and mass spectroscopy. Only trace amounts of this metabolite were formed from the N-oxides of lasiocarpine or heliotrine, and it was not formed from supinine.
ACKNOWLEDGMENT We wish to thank Miss K. Moss, for technical assistance.
- Copyright ©, 1970, by Academic Press Inc.
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