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Molecular Pharmacology

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Research ArticleArticle

The CYP2D6 Humanized Mouse: Effect of the HumanCYP2D6 Transgene and HNF4α on the Disposition of Debrisoquine in the Mouse

Javier Corchero, Camille P. Granvil, Taro E. Akiyama, Graham P. Hayhurst, Satish Pimprale, Lionel Feigenbaum, Jeffrey R. Idle and Frank J. Gonzalez
Molecular Pharmacology December 2001, 60 (6) 1260-1267; DOI: https://doi.org/10.1124/mol.60.6.1260
Javier Corchero
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Camille P. Granvil
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Taro E. Akiyama
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Graham P. Hayhurst
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Satish Pimprale
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Lionel Feigenbaum
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Jeffrey R. Idle
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Frank J. Gonzalez
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Article Information

vol. 60 no. 6 1260-1267
DOI 
https://doi.org/10.1124/mol.60.6.1260
PubMed 
11723233

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received June 13, 2001
  • Accepted August 10, 2001
  • Published online December 1, 2001.

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Javier Corchero1,
  2. Camille P. Granvil1,
  3. Taro E. Akiyama1,
  4. Graham P. Hayhurst1,1,
  5. Satish Pimprale2,1,
  6. Lionel Feigenbaum2,
  7. Jeffrey R. Idle3,3, and
  8. Frank J. Gonzalez1
  1. 1Laboratory of Metabolism (J.C., C.P.G., T.E.A., G.P.H., S.P., F.J.G.) and 2Laboratory Animal Resources (L.F.), National Cancer Institute, National Institutes of Health, Bethesda, Maryland; and 3Institute for Cancer Research and Molecular Biology (J.R.I.), Norwegian University of Science and Technology, Trondheim, Norway
  1. Dr. Frank J. Gonzalez, Laboratory of Metabolism, National Cancer Institute, Building, 37, Room 3E24, Bethesda, MD 20892. E-mail:fjgonz{at}helix.nih.gov
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Molecular Pharmacology: 60 (6)
Molecular Pharmacology
Vol. 60, Issue 6
1 Dec 2001
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Research ArticleArticle

The CYP2D6 Humanized Mouse: Effect of the HumanCYP2D6 Transgene and HNF4α on the Disposition of Debrisoquine in the Mouse

Javier Corchero, Camille P. Granvil, Taro E. Akiyama, Graham P. Hayhurst, Satish Pimprale, Lionel Feigenbaum, Jeffrey R. Idle and Frank J. Gonzalez
Molecular Pharmacology December 1, 2001, 60 (6) 1260-1267; DOI: https://doi.org/10.1124/mol.60.6.1260

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Research ArticleArticle

The CYP2D6 Humanized Mouse: Effect of the HumanCYP2D6 Transgene and HNF4α on the Disposition of Debrisoquine in the Mouse

Javier Corchero, Camille P. Granvil, Taro E. Akiyama, Graham P. Hayhurst, Satish Pimprale, Lionel Feigenbaum, Jeffrey R. Idle and Frank J. Gonzalez
Molecular Pharmacology December 1, 2001, 60 (6) 1260-1267; DOI: https://doi.org/10.1124/mol.60.6.1260
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