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Research ArticleArticle

A Novel Human Nicotinic Receptor Subunit, α10, That Confers Functionality to the α9-Subunit

Frédéric Sgard, Eric Charpantier, Sonia Bertrand, Nancy Walker, Daniel Caput, David Graham, Daniel Bertrand and François Besnard
Molecular Pharmacology January 2002, 61 (1) 150-159; DOI: https://doi.org/10.1124/mol.61.1.150
Frédéric Sgard
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Eric Charpantier
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Sonia Bertrand
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Nancy Walker
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Daniel Caput
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David Graham
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Daniel Bertrand
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François Besnard
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Abstract

We present herein the cloning of the human nicotinic acetylcholine receptor α9-ortholog and the identification of a new α-like subunit (α10) that shares 58% identity with α9. Whereas α10 fails to produce functional receptors alone, it promoted robust acetylcholine-evoked currents when coinjected with α9. The presence of α10 modifies the physiological and pharmacological properties of the α9 receptor indicating that the two subunits coassemble in a single functional receptor. Fusing the N-terminal domain of α9 with the rest of the α10-cDNA yielded a functional α9:α10-chimera that displays the acetylcholine binding properties of α9 and ionic pore characteristics of α10-containing receptors. In addition, α9- and α10-subunit mRNAs show limited similar tissue distribution patterns and are expressed in cochlea, pituitary gland, and keratinocytes. These data suggest that, in vivo, α9-containing receptors coassemble with α10-subunit.

  • The American Society for Pharmacology and Experimental Therapeutics
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Molecular Pharmacology: 61 (1)
Molecular Pharmacology
Vol. 61, Issue 1
1 Jan 2002
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Research ArticleArticle

A Novel Human Nicotinic Receptor Subunit, α10, That Confers Functionality to the α9-Subunit

Frédéric Sgard, Eric Charpantier, Sonia Bertrand, Nancy Walker, Daniel Caput, David Graham, Daniel Bertrand and François Besnard
Molecular Pharmacology January 1, 2002, 61 (1) 150-159; DOI: https://doi.org/10.1124/mol.61.1.150

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Research ArticleArticle

A Novel Human Nicotinic Receptor Subunit, α10, That Confers Functionality to the α9-Subunit

Frédéric Sgard, Eric Charpantier, Sonia Bertrand, Nancy Walker, Daniel Caput, David Graham, Daniel Bertrand and François Besnard
Molecular Pharmacology January 1, 2002, 61 (1) 150-159; DOI: https://doi.org/10.1124/mol.61.1.150
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