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Rapid CommunicationAccelerated Communication

Identification of a Novel Dioxin-Inducible Cytochrome P450

Steven P. Rivera, Sirkku T. Saarikoski and Oliver Hankinson
Molecular Pharmacology February 2002, 61 (2) 255-259; DOI: https://doi.org/10.1124/mol.61.2.255
Steven P. Rivera
Department of Pathology and Laboratory Medicine, Jonsson Comprehensive Cancer Center, and Molecular Biology Institute, UCLA, Los Angeles, California
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Sirkku T. Saarikoski
Department of Pathology and Laboratory Medicine, Jonsson Comprehensive Cancer Center, and Molecular Biology Institute, UCLA, Los Angeles, California
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Oliver Hankinson
Department of Pathology and Laboratory Medicine, Jonsson Comprehensive Cancer Center, and Molecular Biology Institute, UCLA, Los Angeles, California
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Abstract

Representational difference analysis was used to isolate cDNAs corresponding to 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin)-inducible genes from mouse Hepa-1 cells. One cDNA encoded a novel cytochrome P450. The human homolog was also isolated and later proved to be human CYP2S1. The induction of mouse CYP2S1 mRNA by dioxin represents a primary response and required the aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator proteins. The induction of CYP2S1 also occurred in mouse liver and lung, with the highest expression found in lung. CYP2S1 was also inducible in a human lung epithelial cell line. The dioxin-inducibility of CY2S1 is exceptional, because all previously well-characterized cases of the induction of cytochromes P450 by dioxin involve members of the CYP1 family.

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Molecular Pharmacology: 61 (2)
Molecular Pharmacology
Vol. 61, Issue 2
1 Feb 2002
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Rapid CommunicationAccelerated Communication

Identification of a Novel Dioxin-Inducible Cytochrome P450

Steven P. Rivera, Sirkku T. Saarikoski and Oliver Hankinson
Molecular Pharmacology February 1, 2002, 61 (2) 255-259; DOI: https://doi.org/10.1124/mol.61.2.255

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Rapid CommunicationAccelerated Communication

Identification of a Novel Dioxin-Inducible Cytochrome P450

Steven P. Rivera, Sirkku T. Saarikoski and Oliver Hankinson
Molecular Pharmacology February 1, 2002, 61 (2) 255-259; DOI: https://doi.org/10.1124/mol.61.2.255
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