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Research ArticleArticle

Midazolam Oxidation by Cytochrome P450 3A4 and Active-Site Mutants: an Evaluation of Multiple Binding Sites and of the Metabolic Pathway That Leads to Enzyme Inactivation

Kishore K. Khan, You Qun He, Tammy L. Domanski and James R. Halpert
Molecular Pharmacology March 2002, 61 (3) 495-506; DOI: https://doi.org/10.1124/mol.61.3.495

Article Information

vol. 61 no. 3 495-506
DOI 
https://doi.org/10.1124/mol.61.3.495
PubMed 
11854429
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received July 13, 2001
  • Accepted November 28, 2001
  • Published online March 1, 2002.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Kishore K. Khan,
  2. You Qun He,
  3. Tammy L. Domanski, and
  4. James R. Halpert
  1. Department of Pharmacology and Toxicology, The University of Texas Medical Branch, Galveston, Texas.
  1. Kishore K. Khan, Ph.D., Department of Pharmacology and Toxicology, The University of Texas Medical Branch, Route 1031, 301 University Boulevard, Galveston, Texas 77555-1031. E-mail: kkkhan{at}utmb.edu
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Research ArticleArticle

Midazolam Oxidation by Cytochrome P450 3A4 and Active-Site Mutants: an Evaluation of Multiple Binding Sites and of the Metabolic Pathway That Leads to Enzyme Inactivation

Kishore K. Khan, You Qun He, Tammy L. Domanski and James R. Halpert
Molecular Pharmacology March 1, 2002, 61 (3) 495-506; DOI: https://doi.org/10.1124/mol.61.3.495
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