Midazolam Oxidation by Cytochrome P450 3A4 and Active-Site Mutants: an Evaluation of Multiple Binding Sites and of the Metabolic Pathway That Leads to Enzyme Inactivation

Kishore K. Khan, Ph.D., Department of Pharmacology and Toxicology, The University of Texas Medical Branch, Route 1031, 301 University Boulevard, Galveston, Texas 77555-1031. E-mail: kkkhan{at}utmb.edu

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