Midazolam Oxidation by Cytochrome P450 3A4 and Active-Site Mutants: an Evaluation of Multiple Binding Sites and of the Metabolic Pathway That Leads to Enzyme Inactivation

Kishore K. Khan, Ph.D., Department of Pharmacology and Toxicology, The University of Texas Medical Branch, Route 1031, 301 University Boulevard, Galveston, Texas 77555-1031. E-mail: kkkhan{at}utmb.edu

View Full Text

Statistics from Altmetric.com

Article usage

Article usage: February 2002 to June 2021

	Abstract	Full	Pdf
Feb 2002	50	61	112
Mar 2002	22	88	95
Apr 2002	7	57	53
May 2002	4	38	64
Jun 2002	3	36	50
Jul 2002	2	20	48
Aug 2002	3	22	33
Sep 2002	3	19	23
Oct 2002	3	24	33
Nov 2002	1	24	23
Dec 2002	2	14	14
Jan 2003	1	25	32
Feb 2003	7	28	26
Mar 2003	0	26	43
Apr 2003	1	20	20
May 2003	0	22	38
Jun 2003	1	24	34
Jul 2003	9	26	28
Aug 2003	4	22	20
Sep 2003	6	23	25
Oct 2003	8	28	31
Nov 2003	13	36	24
Dec 2003	15	42	18
Jan 2004	9	27	31
Feb 2004	9	45	37
Mar 2004	14	58	44
Apr 2004	7	30	18
May 2004	13	30	14
Jun 2004	11	33	34
Jul 2004	23	31	14
Aug 2004	18	33	33
Sep 2004	18	35	27
Oct 2004	22	34	38
Nov 2004	29	45	33
Dec 2004	15	49	30
Jan 2005	20	27	23
Feb 2005	14	45	17
Mar 2005	24	32	26
Apr 2005	8	25	15
May 2005	8	31	27
Jun 2005	9	43	39
Jul 2005	11	25	25
Aug 2005	12	26	41
Sep 2005	12	36	19
Oct 2005	16	33	17
Nov 2005	12	39	26
Dec 2005	5	20	19
Jan 2006	15	38	29
Feb 2006	11	34	20
Mar 2006	8	50	13
Apr 2006	16	27	14
May 2006	5	24	20
Jun 2006	8	15	11
Jul 2006	9	26	16
Aug 2006	9	23	11
Sep 2006	8	20	19
Oct 2006	8	29	23
Nov 2006	20	43	24
Dec 2006	9	12	13
Jan 2007	14	32	18
Feb 2007	11	16	24
Mar 2007	28	35	40
Apr 2007	11	34	28
May 2007	5	27	19
Jun 2007	17	19	15
Jul 2007	9	18	15
Aug 2007	8	23	16
Sep 2007	9	18	18
Oct 2007	9	8	17
Nov 2007	14	17	20
Dec 2007	5	18	18
Jan 2008	6	20	14
Feb 2008	7	21	26
Mar 2008	13	25	29
Apr 2008	13	44	16
May 2008	8	17	28
Jun 2008	17	22	17
Jul 2008	16	24	25
Aug 2008	24	26	8
Sep 2008	33	24	10
Oct 2008	32	13	16
Nov 2008	18	15	12
Dec 2008	12	14	11
Jan 2009	7	18	10
Feb 2009	15	11	12
Mar 2009	28	15	8
Apr 2009	22	12	17
May 2009	12	9	14
Jun 2009	10	7	14
Jul 2009	7	6	7
Aug 2009	9	6	8
Sep 2009	12	11	13
Oct 2009	20	9	13
Nov 2009	9	13	12
Dec 2009	5	9	11
Jan 2010	11	9	4
Feb 2010	11	7	10
Mar 2010	11	5	14
Apr 2010	6	10	7
May 2010	13	19	17
Jun 2010	12	15	19
Jul 2010	11	15	10
Aug 2010	5	10	10
Sep 2010	9	8	13
Oct 2010	15	8	19
Nov 2010	8	9	10
Dec 2010	13	13	14
Jan 2011	11	7	9
Feb 2011	12	10	14
Mar 2011	17	15	27
Apr 2011	21	8	9
May 2011	26	17	23
Jun 2011	12	11	15
Jul 2011	15	10	12
Aug 2011	12	9	19
Sep 2011	28	10	22
Oct 2011	20	8	22
Nov 2011	24	13	25
Dec 2011	9	12	23
Jan 2012	16	15	21
Feb 2012	15	8	24
Mar 2012	12	16	21
Apr 2012	15	15	31
May 2012	17	19	22
Jun 2012	12	8	21
Jul 2012	13	9	22
Aug 2012	6	10	13
Sep 2012	7	3	17
Oct 2012	10	7	12
Nov 2012	13	9	16
Dec 2012	16	7	18
Jan 2013	30	27	20
Feb 2013	20	10	21
Mar 2013	18	11	10
Apr 2013	29	19	24
May 2013	12	12	18
Jun 2013	3	7	14
Jul 2013	13	9	15
Aug 2013	8	4	5
Sep 2013	16	7	6
Oct 2013	10	8	22
Nov 2013	15	15	23
Dec 2013	9	4	18
Jan 2014	12	11	15
Feb 2014	15	4	22
Mar 2014	10	2	19
Apr 2014	5	6	25
May 2014	17	11	15
Jun 2014	4	10	12
Jul 2014	23	13	13
Aug 2014	2	7	7
Sep 2014	16	5	14
Oct 2014	13	13	22
Nov 2014	10	5	8
Dec 2014	12	13	20
Jan 2015	13	7	17
Feb 2015	7	2	10
Mar 2015	17	11	19
Apr 2015	8	12	21
May 2015	24	6	13
Jun 2015	18	15	19
Jul 2015	15	26	28
Aug 2015	9	6	9
Sep 2015	9	4	12
Oct 2015	6	14	11
Nov 2015	10	9	11
Dec 2015	8	10	10
Jan 2016	10	10	11
Feb 2016	13	16	17
Mar 2016	18	7	17
Apr 2016	15	5	19
May 2016	6	15	11
Jun 2016	27	5	16
Jul 2016	8	14	5
Aug 2016	7	5	6
Sep 2016	12	17	7
Oct 2016	12	14	8
Nov 2016	4	27	6
Dec 2016	5	32	16
Jan 2017	2	11	6
Feb 2017	4	22	5
Mar 2017	10	18	7
Apr 2017	7	25	13
May 2017	3	25	26
Jun 2017	6	28	18
Jul 2017	7	24	28
Aug 2017	6	33	16
Sep 2017	1	24	23
Oct 2017	2	36	16
Nov 2017	2	32	18
Dec 2017	5	17	10
Jan 2018	5	13	15
Feb 2018	1	16	18
Mar 2018	0	29	14
Apr 2018	0	22	9
May 2018	0	24	22
Jun 2018	1	10	10
Jul 2018	3	15	20
Aug 2018	1	7	11
Sep 2018	4	14	11
Oct 2018	2	22	11
Nov 2018	1	23	20
Dec 2018	26	12	12
Jan 2019	24	4	2
Feb 2019	12	2	3
Mar 2019	14	8	8
Apr 2019	21	11	4
May 2019	18	3	6
Jun 2019	20	0	4
Jul 2019	13	5	4
Aug 2019	25	2	5
Sep 2019	21	6	5
Oct 2019	24	5	6
Nov 2019	27	5	5
Dec 2019	27	13	3
Jan 2020	25	8	3
Feb 2020	28	0	3
Mar 2020	14	8	8
Apr 2020	18	5	5
May 2020	16	4	3
Jun 2020	11	0	0
Jul 2020	8	2	4
Aug 2020	5	0	0
Sep 2020	17	4	5
Oct 2020	10	6	4
Nov 2020	12	1	1
Dec 2020	29	4	2
Jan 2021	12	37	1
Feb 2021	15	34	3
Mar 2021	28	6	1
Apr 2021	23	8	5
May 2021	25	14	1
Jun 2021	9	17	1