Midazolam Oxidation by Cytochrome P450 3A4 and Active-Site Mutants: an Evaluation of Multiple Binding Sites and of the Metabolic Pathway That Leads to Enzyme Inactivation

Kishore K. Khan; You Qun He; Tammy L. Domanski; James R. Halpert

doi:10.1124/mol.61.3.495

Research ArticleArticle

Midazolam Oxidation by Cytochrome P450 3A4 and Active-Site Mutants: an Evaluation of Multiple Binding Sites and of the Metabolic Pathway That Leads to Enzyme Inactivation

Kishore K. Khan, You Qun He, Tammy L. Domanski and James R. Halpert

Molecular Pharmacology March 2002, 61 (3) 495-506; DOI: https://doi.org/10.1124/mol.61.3.495

Kishore K. Khan

Department of Pharmacology and Toxicology, The University of Texas Medical Branch, Galveston, Texas.

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You Qun He

Department of Pharmacology and Toxicology, The University of Texas Medical Branch, Galveston, Texas.

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Tammy L. Domanski

Department of Pharmacology and Toxicology, The University of Texas Medical Branch, Galveston, Texas.

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James R. Halpert

Department of Pharmacology and Toxicology, The University of Texas Medical Branch, Galveston, Texas.

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Molecular Pharmacology

Vol. 61, Issue 3

1 Mar 2002

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Research ArticleArticle

Midazolam Oxidation by Cytochrome P450 3A4 and Active-Site Mutants: an Evaluation of Multiple Binding Sites and of the Metabolic Pathway That Leads to Enzyme Inactivation

Kishore K. Khan, You Qun He, Tammy L. Domanski and James R. Halpert

Molecular Pharmacology March 1, 2002, 61 (3) 495-506; DOI: https://doi.org/10.1124/mol.61.3.495

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Research ArticleArticle

Midazolam Oxidation by Cytochrome P450 3A4 and Active-Site Mutants: an Evaluation of Multiple Binding Sites and of the Metabolic Pathway That Leads to Enzyme Inactivation

Kishore K. Khan, You Qun He, Tammy L. Domanski and James R. Halpert

Molecular Pharmacology March 1, 2002, 61 (3) 495-506; DOI: https://doi.org/10.1124/mol.61.3.495

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