Table of Contents

Articles

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  Parthenolide, an Inhibitor of the Nuclear Factor-κB Pathway, Ameliorates Cardiovascular Derangement and Outcome in Endotoxic Shock in Rodents

  Maeve Sheehan, Hector R. Wong, Paul W. Hake, Vivek Malhotra, Michael O'Connor and Basilia Zingarelli

  Molecular Pharmacology May 2002, 61 (5) 953-963; DOI: https://doi.org/10.1124/mol.61.5.953
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  Three-Dimensional Quantitative Structure-Activity Relationships of Inhibitors of P-Glycoprotein

  Sean Ekins, Richard B. Kim, Brenda F. Leake, Anne H. Dantzig, Erin G. Schuetz, Lu-Bin Lan, Kazuto Yasuda, Robert L. Shepard, Mark A. Winter, John D. Schuetz, James H. Wikel and Steven A. Wrighton

  Molecular Pharmacology May 2002, 61 (5) 964-973; DOI: https://doi.org/10.1124/mol.61.5.964
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  Application of Three-Dimensional Quantitative Structure-Activity Relationships of P-Glycoprotein Inhibitors and Substrates

  Sean Ekins, Richard B. Kim, Brenda F. Leake, Anne H. Dantzig, Erin G. Schuetz, Lu-Bin Lan, Kazuto Yasuda, Robert L. Shepard, Mark a Winter, John D. Schuetz, James H. Wikel and Steven A. Wrighton

  Molecular Pharmacology May 2002, 61 (5) 974-981; DOI: https://doi.org/10.1124/mol.61.5.974
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  Expression and Functional Characterization of Rat Organic Anion Transporter 3 (rOat3) in the Choroid Plexus

  Yoshinori Nagata, Hiroyuki Kusuhara, Hitoshi Endou and Yuichi Sugiyama

  Molecular Pharmacology May 2002, 61 (5) 982-988; DOI: https://doi.org/10.1124/mol.61.5.982
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  l-Acetylcarnitine Induces Analgesia by Selectively Up-Regulating mGlu2 Metabotropic Glutamate Receptors

  S. Chiechio, A. Caricasole, E. Barletta, M. Storto, M. V. Catania, A. Copani, M. Vertechy, R. Nicolai, M. Calvani, D. Melchiorri and F. Nicoletti

  Molecular Pharmacology May 2002, 61 (5) 989-996; DOI: https://doi.org/10.1124/mol.61.5.989
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  The Cyclopentenone Prostaglandin 15-Deoxy-Δ^12,14-Prostaglandin J₂Attenuates the Development of Acute and Chronic Inflammation

  Salvatore Cuzzocrea, Nicole S. Wayman, Emanuela Mazzon, Laura Dugo, Rosanna Di Paola, Ivana Serraino, Domenico Britti, Prabal K. Chatterjee, Achille P. Caputi and Christoph Thiemermann

  Molecular Pharmacology May 2002, 61 (5) 997-1007; DOI: https://doi.org/10.1124/mol.61.5.997
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  Differences in the Cellular Localization and Agonist-Mediated Internalization Properties of the α₁-Adrenoceptor Subtypes

  Dan Chalothorn, Dan F. McCune, Stephanie E. Edelmann, Mary L. Garcı́a-Cazarı́n, Gozoh Tsujimoto and Michael T. Piascik

  Molecular Pharmacology May 2002, 61 (5) 1008-1016; DOI: https://doi.org/10.1124/mol.61.5.1008
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  Antidepressant Treatments Induce the Expression of Basic Fibroblast Growth Factor in Cortical and Hippocampal Neurons

  Alessandra Mallei, Bitao Shi and Italo Mocchetti

  Molecular Pharmacology May 2002, 61 (5) 1017-1024; DOI: https://doi.org/10.1124/mol.61.5.1017
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  Mutagenesis and Modelling of the α_1b-Adrenergic Receptor Highlight the Role of the Helix 3/Helix 6 Interface in Receptor Activation

  Peter J. Greasley, Francesca Fanelli, Olivier Rossier, Liliane Abuin and Susanna Cotecchia

  Molecular Pharmacology May 2002, 61 (5) 1025-1032; DOI: https://doi.org/10.1124/mol.61.5.1025
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  Reduced Phosphodiesterase 3 Activity and Phosphodiesterase 3A Level in Synthetic Vascular Smooth Muscle Cells: Implications for Use of Phosphodiesterase 3 Inhibitors in Cardiovascular Tissues

  Heather A. Dunkerley, Douglas G. Tilley, Daniel Palmer, Hanguan Liu, Sandra L. Jimmo and Donald H. Maurice

  Molecular Pharmacology May 2002, 61 (5) 1033-1040; DOI: https://doi.org/10.1124/mol.61.5.1033
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  Refinement of the Conformation of a Critical Region of Charge-Charge Interaction between Cholecystokinin and Its Receptor

  Xi-Qin Ding, Delia I. Pinon, Kristina E. Furse, Terry P. Lybrand and Laurence J. Miller

  Molecular Pharmacology May 2002, 61 (5) 1041-1052; DOI: https://doi.org/10.1124/mol.61.5.1041
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  2-Methoxyestradiol and Analogs as Novel Antiproliferative Agents: Analysis of Three-Dimensional Quantitative Structure-Activity Relationships for DNA Synthesis Inhibition and Estrogen Receptor Binding

  Richard A. Hughes, Trudi Harris, Emile Altmann, David McAllister, Ross Vlahos, Alan Robertson, Mark Cushman, Zhiqiang Wang and Alastair G. Stewart

  Molecular Pharmacology May 2002, 61 (5) 1053-1069; DOI: https://doi.org/10.1124/mol.61.5.1053
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  Importance of the γ-Aminobutyric Acid_B Receptor C-Termini for G-Protein Coupling

  Sylvia Grünewald, Bettina J. Schupp, Stephen R. Ikeda, Rohini Kuner, Frank Steigerwald, Hans-Christian Kornau and Georg Köhr

  Molecular Pharmacology May 2002, 61 (5) 1070-1080; DOI: https://doi.org/10.1124/mol.61.5.1070
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  Functional and Analytical Evidence for Scavenging of Oxygen Radicals by l-Arginine

  Achim Lass, Astrid Suessenbacher, Gerald Wölkart, Bernd Mayer and Friedrich Brunner

  Molecular Pharmacology May 2002, 61 (5) 1081-1088; DOI: https://doi.org/10.1124/mol.61.5.1081
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  Post-Transcriptional Regulation of Hepatic NADPH-Cytochrome P450 Reductase by Thyroid Hormone: Independent Effects on Poly(A) Tail Length and mRNA Stability

  Dongxu Liu and David J. Waxman

  Molecular Pharmacology May 2002, 61 (5) 1089-1096; DOI: https://doi.org/10.1124/mol.61.5.1089
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  Up-Regulation of Glutamate Receptors in Nucleus Tractus Solitarii Underlies Potentiation of Baroreceptor Reflex by Heat Shock Protein 70

  Samuel H. H. Chan, Kui-Fen Chang, Chen-Chun Ou and Julie Y. H. Chan

  Molecular Pharmacology May 2002, 61 (5) 1097-1104; DOI: https://doi.org/10.1124/mol.61.5.1097
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  Ethylbromide Tamoxifen, a Membrane-Impermeant Antiestrogen, Activates Smooth Muscle Calcium-Activated Large-Conductance Potassium Channels from the Extracellular Side

  Gregory M. Dick, A. Christy Hunter and Kenton M. Sanders

  Molecular Pharmacology May 2002, 61 (5) 1105-1113; DOI: https://doi.org/10.1124/mol.61.5.1105
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  Metabotropic Glutamate Receptor 1 Internalization Induced by Muscarinic Acetylcholine Receptor Activation: Differential Dependency of Internalization of Splice Variants on Nonvisual Arrestins

  Stuart J. Mundell, Anne-Lise Matharu, Giordano Pula, David Holman, Peter J. Roberts and Eamonn Kelly

  Molecular Pharmacology May 2002, 61 (5) 1114-1123; DOI: https://doi.org/10.1124/mol.61.5.1114
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  Methamphetamine Causes Coordinate Regulation of Src, Cas, Crk, and the Jun N-Terminal Kinase–Jun Pathway

  Subramaniam Jayanthi, Michael T. McCoy, Bruce Ladenheim and Jean Lud Cadet

  Molecular Pharmacology May 2002, 61 (5) 1124-1131; DOI: https://doi.org/10.1124/mol.61.5.1124
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  Five Amino Acids of the Xenopus laevis CRF (Corticotropin-Releasing Factor) Type 2 Receptor Mediate Differential Binding of CRF Ligands in Comparison with Its Human Counterpart

  Frank M. Dautzenberg, Jacqueline Higelin, Olaf Brauns, Brigitte Butscha and Richard L. Hauger

  Molecular Pharmacology May 2002, 61 (5) 1132-1139; DOI: https://doi.org/10.1124/mol.61.5.1132
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  Lack of Susceptibility of Bicyclic Nucleoside Analogs, Highly Potent Inhibitors of Varicella-Zoster Virus, to the Catabolic Action of Thymidine Phosphorylase and Dihydropyrimidine Dehydrogenase

  Jan Balzarini, Rebecca Sienaert, Sandra Liekens, André Van Kuilenburg, Antonella Carangio, Robert Esnouf, Erik De Clercq and Chris McGuigan

  Molecular Pharmacology May 2002, 61 (5) 1140-1145; DOI: https://doi.org/10.1124/mol.61.5.1140
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  Native CYP2C11: Heterologous Expression in Saccharomyces cerevisiae Reveals a Role for Vacuolar Proteases Rather Than the Proteasome System in the Degradation of This Endoplasmic Reticulum Protein

  Bernard P. Murray, Victor G. Zgoda and Maria Almira Correia

  Molecular Pharmacology May 2002, 61 (5) 1146-1153; DOI: https://doi.org/10.1124/mol.61.5.1146
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  A G-Quadruplex-Interactive Potent Small-Molecule Inhibitor of Telomerase Exhibiting in Vitro and in Vivo Antitumor Activity

  Sharon M. Gowan, John R. Harrison, Lisa Patterson, Melanie Valenti, Martin A. Read, Stephen Neidle and Lloyd R. Kelland

  Molecular Pharmacology May 2002, 61 (5) 1154-1162; DOI: https://doi.org/10.1124/mol.61.5.1154
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  Regulation of Fibronectin Fibrillogenesis by Protein Kinases in Cultured Rat Osteoblasts

  Rong-Sen Yang, Chih-Hsin Tang, Qing-Dong Ling, Shing-Hwa Liu and Wen-Mei Fu

  Molecular Pharmacology May 2002, 61 (5) 1163-1173; DOI: https://doi.org/10.1124/mol.61.5.1163
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  Identification of Albumin Precursor Protein, Phi AP3, and α-Smooth Muscle Actin as Novel Components of Redox Sensing Machinery in Vascular Smooth Muscle Cells

  M. T. Holderman, K. P. Miller, L. J. Dangott and K. S. Ramos

  Molecular Pharmacology May 2002, 61 (5) 1174-1183; DOI: https://doi.org/10.1124/mol.61.5.1174
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  Substrate-Induced Up-Regulation of Aldose Reductase by Methylglyoxal, a Reactive Oxoaldehyde Elevated in Diabetes

  Ki Churl Chang, Kyung Shin Paek, Hyo Jung Kim, Young Soo Lee, Chihiro Yabe-Nishimura and Han Geuk Seo

  Molecular Pharmacology May 2002, 61 (5) 1184-1191; DOI: https://doi.org/10.1124/mol.61.5.1184
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  Critical Molecular Determinants of Voltage-Gated Sodium Channel Sensitivity to μ-Conotoxins GIIIA/B

  Theodore R. Cummins, Fabio Aglieco and Sulayman D. Dib-Hajj

  Molecular Pharmacology May 2002, 61 (5) 1192-1201; DOI: https://doi.org/10.1124/mol.61.5.1192
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  The Critical Role of Transmembrane Prolines in Human Prostacyclin Receptor Activation

  Jeremiah Stitham, Kathleen A. Martin and John Hwa

  Molecular Pharmacology May 2002, 61 (5) 1202-1210; DOI: https://doi.org/10.1124/mol.61.5.1202
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  Enhanced Detection of Receptor Constitutive Activity in the Presence of Regulators of G Protein Signaling: Applications to the Detection and Analysis of Inverse Agonists and Low-Efficacy Partial Agonists

  Philip J. Welsby, Elaine Kellett, Graeme Wilkinson and Graeme Milligan

  Molecular Pharmacology May 2002, 61 (5) 1211-1221; DOI: https://doi.org/10.1124/mol.61.5.1211
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  The Nicotinic Allosteric Potentiating Ligand Galantamine Facilitates Synaptic Transmission in the Mammalian Central Nervous System

  Máriton D. Santos, Manickavasagom Alkondon, Edna F. R. Pereira, Yasco Aracava, Howard M. Eisenberg, Alfred Maelicke and Edson X. Albuquerque

  Molecular Pharmacology May 2002, 61 (5) 1222-1234; DOI: https://doi.org/10.1124/mol.61.5.1222
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  Maleimide Is a Potent Inhibitor of Topoisomerase II in Vitro and in Vivo: A New Mode of Catalytic Inhibition

  Lars H. Jensen, Axelle Renodon-Corniere, Irene Wessel, Seppo W. Langer, Birgitte Søkilde, Elisabeth V. Carstensen, Maxwell Sehested and Peter B. Jensen

  Molecular Pharmacology May 2002, 61 (5) 1235-1243; DOI: https://doi.org/10.1124/mol.61.5.1235
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  Supersensitivity of Human Metabotropic Glutamate 1a Receptor Signaling in L929sA Cells

  Hilde Lavreysen, Emmanuel Le Poul, Paul Van Gompel, Lieve Dillen, Josée E. Leysen and Anne S. J. Lesage

  Molecular Pharmacology May 2002, 61 (5) 1244-1254; DOI: https://doi.org/10.1124/mol.61.5.1244
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  Further Insight into Mechanism of Action of Clodronate: Inhibition of Mitochondrial ADP/ATP Translocase by a Nonhydrolyzable, Adenine-Containing Metabolite

  Petri P. Lehenkari, Maarit Kellinsalmi, Juha P. Näpänkangas, Kari V. Ylitalo, Jukka Mönkkönen, Michael J. Rogers, Alex Azhayev, H. Kalervo Väänänen and Ilmo E. Hassinen

  Molecular Pharmacology May 2002, 61 (5) 1255-1262; DOI: https://doi.org/10.1124/mol.61.5.1255