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Research ArticleArticle

Functional and Analytical Evidence for Scavenging of Oxygen Radicals by l-Arginine

Achim Lass, Astrid Suessenbacher, Gerald Wölkart, Bernd Mayer and Friedrich Brunner
Molecular Pharmacology May 2002, 61 (5) 1081-1088; DOI: https://doi.org/10.1124/mol.61.5.1081
Achim Lass
Department of Pharmacology and Toxicology, Karl-Franzens-Universität Graz, Graz, Austria
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Astrid Suessenbacher
Department of Pharmacology and Toxicology, Karl-Franzens-Universität Graz, Graz, Austria
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Gerald Wölkart
Department of Pharmacology and Toxicology, Karl-Franzens-Universität Graz, Graz, Austria
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Bernd Mayer
Department of Pharmacology and Toxicology, Karl-Franzens-Universität Graz, Graz, Austria
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Friedrich Brunner
Department of Pharmacology and Toxicology, Karl-Franzens-Universität Graz, Graz, Austria
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Abstract

l-Arginine, the substrate of nitric oxide synthase, is known to exert favorable effects in the prevention and treatment of cardiovascular diseases. In several conditions, including atherosclerosis and ischemia/reperfusion, where oxygen metabolites are thought to mediate endothelial and myocardial injury,l-arginine has protective effects. Here we studied the mechanisms by which l-arginine protects against oxygen radical-induced myocardial injury. Buffer-perfused rat hearts were subjected to oxygen radicals generated by electrolysis or to hypoxanthine and xanthine oxidase, which generates superoxide anions (O⨪2). Both sources of radicals impaired myocardial contractility, whereas l-arginine prevented the impairment. The observation that d-arginine as well as nitric oxide synthase inhibitors, such asN G-nitro-l-arginine but not glycine, had similar cardioprotective effects indicated that the protection might be due to a direct chemical interaction ofl-arginine and its derivatives with oxygen radicals. In support, l-arginine and the derivatives prevented the formation of O⨪2 as determined by sensitive standard methods, whereas glycine did not. The radical scavenging activity ofl-arginine and derivatives was dose-dependent, with an apparent rate constant of approximately 4.8 × 103 M s−1 for the reaction of l-arginine with O⨪2 as determined by electron paramagnetic resonance spectroscopy using 1-hydroxy-2,2,6,6-tetramethyl-4-oxo-piperidine (TEMPONE-H) as spin trap. In summary, the results of this study demonstrate protective effects of l-arginine against oxygen radical-induced cardiac injury by free radical scavenging.

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Molecular Pharmacology: 61 (5)
Molecular Pharmacology
Vol. 61, Issue 5
1 May 2002
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Research ArticleArticle

Functional and Analytical Evidence for Scavenging of Oxygen Radicals by l-Arginine

Achim Lass, Astrid Suessenbacher, Gerald Wölkart, Bernd Mayer and Friedrich Brunner
Molecular Pharmacology May 1, 2002, 61 (5) 1081-1088; DOI: https://doi.org/10.1124/mol.61.5.1081

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Research ArticleArticle

Functional and Analytical Evidence for Scavenging of Oxygen Radicals by l-Arginine

Achim Lass, Astrid Suessenbacher, Gerald Wölkart, Bernd Mayer and Friedrich Brunner
Molecular Pharmacology May 1, 2002, 61 (5) 1081-1088; DOI: https://doi.org/10.1124/mol.61.5.1081
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