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Research ArticleArticle

Lack of Susceptibility of Bicyclic Nucleoside Analogs, Highly Potent Inhibitors of Varicella-Zoster Virus, to the Catabolic Action of Thymidine Phosphorylase and Dihydropyrimidine Dehydrogenase

Jan Balzarini, Rebecca Sienaert, Sandra Liekens, André Van Kuilenburg, Antonella Carangio, Robert Esnouf, Erik De Clercq and Chris McGuigan
Molecular Pharmacology May 2002, 61 (5) 1140-1145; DOI: https://doi.org/10.1124/mol.61.5.1140

Article Information

vol. 61 no. 5 1140-1145
DOI 
https://doi.org/10.1124/mol.61.5.1140
PubMed 
11961132
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received November 5, 2001
  • Accepted January 25, 2002
  • Published online May 1, 2002.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Jan Balzarini1,
  2. Rebecca Sienaert1,
  3. Sandra Liekens1,
  4. André Van Kuilenburg2,
  5. Antonella Carangio3,
  6. Robert Esnouf4,
  7. Erik De Clercq1, and
  8. Chris McGuigan3
  1. 1Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium (J.B., R.S., S.L., E.D.C.); 2Academic Medical Center, Laboratory of Genetic Metabolic Diseases, Amsterdam, The Netherlands (A.V.K.); 3Welsh School of Pharmacy, University of Wales College, Cardiff, Wales, United Kingdom (A.C., C.M.); and 4Division of Structural Biology, the Wellcome Trust Centre for Human Genetics, Oxford, England, United Kingdom (R.E.)
  1. Dr. Jan Balzarini, Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium. E-mail: jan.balzarini{at}rega.kuleuven.ac.be
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Research ArticleArticle

Lack of Susceptibility of Bicyclic Nucleoside Analogs, Highly Potent Inhibitors of Varicella-Zoster Virus, to the Catabolic Action of Thymidine Phosphorylase and Dihydropyrimidine Dehydrogenase

Jan Balzarini, Rebecca Sienaert, Sandra Liekens, André Van Kuilenburg, Antonella Carangio, Robert Esnouf, Erik De Clercq and Chris McGuigan
Molecular Pharmacology May 1, 2002, 61 (5) 1140-1145; DOI: https://doi.org/10.1124/mol.61.5.1140
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