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Research ArticleArticle

Maleimide Is a Potent Inhibitor of Topoisomerase II in Vitro and in Vivo: A New Mode of Catalytic Inhibition

Lars H. Jensen, Axelle Renodon-Corniere, Irene Wessel, Seppo W. Langer, Birgitte Søkilde, Elisabeth V. Carstensen, Maxwell Sehested and Peter B. Jensen
Molecular Pharmacology May 2002, 61 (5) 1235-1243; DOI: https://doi.org/10.1124/mol.61.5.1235

Article Information

vol. 61 no. 5 1235-1243
DOI 
https://doi.org/10.1124/mol.61.5.1235
PubMed 
11961142
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received September 13, 2001
  • Accepted February 13, 2002
  • Published online May 1, 2002.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Lars H. Jensen1,2,3,
  2. Axelle Renodon-Corniere2,
  3. Irene Wessel2,3,
  4. Seppo W. Langer1,3,
  5. Birgitte Søkilde3,
  6. Elisabeth V. Carstensen3,
  7. Maxwell Sehested2,3, and
  8. Peter B. Jensen1,3
  1. 1Laboratory for Experimental Medical Oncology, Finsen Center, Copenhagen, Denmark (L.H.J., S.W.L., P.B.J.); 2Department of Pathology, Laboratory Center, Copenhagen, Denmark (L.H.J., A.-R.C., I.W., M.S.); and 3Topo Target A/S, Copenhagen, Denmark (L.H.J., I.W., S.W.L., B.S., E.V.C., M.S., P.B.J.)
  1. Peter Buhl Jensen, Laboratory for Experimental Medical Oncology RH 5074, Finsen Center, Righospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.
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Research ArticleArticle

Maleimide Is a Potent Inhibitor of Topoisomerase II in Vitro and in Vivo: A New Mode of Catalytic Inhibition

Lars H. Jensen, Axelle Renodon-Corniere, Irene Wessel, Seppo W. Langer, Birgitte Søkilde, Elisabeth V. Carstensen, Maxwell Sehested and Peter B. Jensen
Molecular Pharmacology May 1, 2002, 61 (5) 1235-1243; DOI: https://doi.org/10.1124/mol.61.5.1235
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