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Research ArticleArticle

Application of Three-Dimensional Quantitative Structure-Activity Relationships of P-Glycoprotein Inhibitors and Substrates

Sean Ekins, Richard B. Kim, Brenda F. Leake, Anne H. Dantzig, Erin G. Schuetz, Lu-Bin Lan, Kazuto Yasuda, Robert L. Shepard, Mark a Winter, John D. Schuetz, James H. Wikel and Steven A. Wrighton
Molecular Pharmacology May 2002, 61 (5) 974-981; DOI: https://doi.org/10.1124/mol.61.5.974
Sean Ekins
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Richard B. Kim
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Brenda F. Leake
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Anne H. Dantzig
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Erin G. Schuetz
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Lu-Bin Lan
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Kazuto Yasuda
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Robert L. Shepard
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Mark a Winter
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John D. Schuetz
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James H. Wikel
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Steven A. Wrighton
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Article Information

vol. 61 no. 5 974-981
DOI 
https://doi.org/10.1124/mol.61.5.974
PubMed 
11961114

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received November 2, 2001
  • Accepted February 13, 2001
  • Published online May 1, 2002.

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Sean Ekins1,
  2. Richard B. Kim2,
  3. Brenda F. Leake2,
  4. Anne H. Dantzig1,
  5. Erin G. Schuetz3,
  6. Lu-Bin Lan3,
  7. Kazuto Yasuda3,
  8. Robert L. Shepard1,
  9. Mark a Winter1,
  10. John D. Schuetz3,
  11. James H. Wikel1, and
  12. Steven A. Wrighton1
  1. 1Lilly Research Laboratories, Eli Lilly and Co., Lilly Corporate Center, Indianapolis, Indiana (S.E., A.H.D., R.L.S., M.A.W., J.H.W., S.A.W.); 2Division of Clinical Pharmacology, Vanderbilt University, Nashville, Tennessee (R.B.K., B.F.L.); 3Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee (E.G.S., L.-B.L., K.Y., J.D.S.)
  1. Sean Ekins, Ph.D., Concurrent Pharmaceuticals Inc., One Broadway, 14th Floor, Cambridge, MA 02142. E-mail: ekinssean{at}yahoo.com
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Molecular Pharmacology: 61 (5)
Molecular Pharmacology
Vol. 61, Issue 5
1 May 2002
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Research ArticleArticle

Application of Three-Dimensional Quantitative Structure-Activity Relationships of P-Glycoprotein Inhibitors and Substrates

Sean Ekins, Richard B. Kim, Brenda F. Leake, Anne H. Dantzig, Erin G. Schuetz, Lu-Bin Lan, Kazuto Yasuda, Robert L. Shepard, Mark a Winter, John D. Schuetz, James H. Wikel and Steven A. Wrighton
Molecular Pharmacology May 1, 2002, 61 (5) 974-981; DOI: https://doi.org/10.1124/mol.61.5.974

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Research ArticleArticle

Application of Three-Dimensional Quantitative Structure-Activity Relationships of P-Glycoprotein Inhibitors and Substrates

Sean Ekins, Richard B. Kim, Brenda F. Leake, Anne H. Dantzig, Erin G. Schuetz, Lu-Bin Lan, Kazuto Yasuda, Robert L. Shepard, Mark a Winter, John D. Schuetz, James H. Wikel and Steven A. Wrighton
Molecular Pharmacology May 1, 2002, 61 (5) 974-981; DOI: https://doi.org/10.1124/mol.61.5.974
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