SB-431542 Is a Potent and Specific Inhibitor of Transforming Growth Factor-β Superfamily Type I Activin Receptor-Like Kinase (ALK) Receptors ALK4, ALK5, and ALK7

Dr. Caroline Hill, Laboratory of Developmental Signalling, Cancer Research UK London Research Institute, Lincoln's Inn Fields Laboratories, 44 Lincoln's Inn Fields, London WC2A 3PX, UK. E-mail: caroline.hill{at}cancer.org.uk

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Jun 2002	65	170	248
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Feb 2004	23	111	87
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Jul 2004	35	124	71
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Oct 2004	40	123	78
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Jul 2005	10	94	69
Aug 2005	19	84	63
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Nov 2005	48	110	85
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Feb 2007	35	78	64
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Jul 2007	36	90	69
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Feb 2008	17	73	56
Mar 2008	49	63	50
Apr 2008	37	92	72
May 2008	60	96	78
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Jul 2008	68	90	64
Aug 2008	111	99	50
Sep 2008	127	130	134
Oct 2008	111	99	69
Nov 2008	140	143	165
Dec 2008	98	110	70
Jan 2009	106	146	75
Feb 2009	115	124	77
Mar 2009	180	152	102
Apr 2009	169	120	122
May 2009	126	120	103
Jun 2009	126	119	91
Jul 2009	156	133	81
Aug 2009	184	115	85
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Dec 2009	206	83	84
Jan 2010	231	116	94
Feb 2010	256	126	80
Mar 2010	251	124	107
Apr 2010	224	173	102
May 2010	213	147	86
Jun 2010	169	175	88
Jul 2010	188	149	95
Aug 2010	234	135	106
Sep 2010	226	164	111
Oct 2010	213	130	99
Nov 2010	240	145	112
Dec 2010	192	136	101
Jan 2011	209	143	91
Feb 2011	245	139	96
Mar 2011	238	142	141
Apr 2011	216	128	124
May 2011	199	128	161
Jun 2011	182	150	106
Jul 2011	210	108	125
Aug 2011	194	145	143
Sep 2011	226	159	116
Oct 2011	244	173	125
Nov 2011	269	153	127
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Jan 2012	247	184	141
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Jul 2012	148	215	111
Aug 2012	150	147	95
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Oct 2012	137	179	143
Nov 2012	115	166	123
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Jan 2013	143	184	136
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Mar 2013	126	196	113
Apr 2013	145	150	103
May 2013	123	147	107
Jun 2013	100	164	114
Jul 2013	119	144	110
Aug 2013	127	85	92
Sep 2013	132	141	120
Oct 2013	190	178	125
Nov 2013	138	178	125
Dec 2013	113	180	115
Jan 2014	156	162	101
Feb 2014	109	160	100
Mar 2014	161	220	120
Apr 2014	130	207	125
May 2014	131	177	111
Jun 2014	125	194	110
Jul 2014	110	204	102
Aug 2014	88	153	93
Sep 2014	91	205	117
Oct 2014	118	258	102
Nov 2014	128	216	84
Dec 2014	159	168	80
Jan 2015	104	180	87
Feb 2015	94	222	95
Mar 2015	147	232	385
Apr 2015	177	259	113
May 2015	170	282	132
Jun 2015	151	244	108
Jul 2015	141	204	82
Aug 2015	103	153	75
Sep 2015	103	141	88
Oct 2015	114	191	138
Nov 2015	87	186	77
Dec 2015	91	185	78
Jan 2016	163	194	84
Feb 2016	219	168	68
Mar 2016	179	262	109
Apr 2016	139	240	102
May 2016	103	255	96
Jun 2016	129	193	76
Jul 2016	99	225	114
Aug 2016	126	232	103
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Oct 2016	41	489	103
Nov 2016	50	366	113
Dec 2016	23	270	63
Jan 2017	18	240	62
Feb 2017	30	241	83
Mar 2017	23	321	80
Apr 2017	16	223	45
May 2017	16	226	72
Jun 2017	17	155	49
Jul 2017	26	191	63
Aug 2017	16	262	67
Sep 2017	19	246	66
Oct 2017	16	203	70
Nov 2017	12	246	60
Dec 2017	17	217	57
Jan 2018	13	270	85
Feb 2018	18	155	68
Mar 2018	20	239	83
Apr 2018	22	367	70
May 2018	22	211	86
Jun 2018	12	199	69
Jul 2018	14	168	84
Aug 2018	16	194	73
Sep 2018	7	178	54
Oct 2018	20	159	66
Nov 2018	20	200	76
Dec 2018	168	77	49
Jan 2019	229	68	27
Feb 2019	253	65	34
Mar 2019	215	67	28
Apr 2019	332	79	37
May 2019	244	73	30
Jun 2019	186	49	25
Jul 2019	200	71	28
Aug 2019	249	104	26
Sep 2019	330	101	15
Oct 2019	198	108	37
Nov 2019	242	59	19
Dec 2019	179	50	23
Jan 2020	256	86	30
Feb 2020	201	51	18
Mar 2020	249	50	24
Apr 2020	217	40	19
May 2020	214	42	26
Jun 2020	122	30	10
Jul 2020	137	38	20
Aug 2020	122	40	18
Sep 2020	147	34	11
Oct 2020	150	28	11
Nov 2020	166	34	16
Dec 2020	221	34	11
Jan 2021	203	52	35
Feb 2021	187	50	20
Mar 2021	299	64	39
Apr 2021	226	44	12
May 2021	252	28	12
Jun 2021	185	56	24
Jul 2021	146	50	15
Aug 2021	205	31	9
Sep 2021	155	66	21
Oct 2021	155	49	27
Nov 2021	201	49	25
Dec 2021	173	34	13
Jan 2022	214	36	15
Feb 2022	229	40	25
Mar 2022	248	53	27
Apr 2022	223	47	23
May 2022	210	53	27
Jun 2022	195	51	16
Jul 2022	194	45	15
Aug 2022	197	33	20
Sep 2022	178	22	19
Oct 2022	287	32	21
Nov 2022	331	24	11
Dec 2022	311	33	16
Jan 2023	309	66	24
Feb 2023	43	4	4