SB-431542 Is a Potent and Specific Inhibitor of Transforming Growth Factor-β Superfamily Type I Activin Receptor-Like Kinase (ALK) Receptors ALK4, ALK5, and ALK7

Dr. Caroline Hill, Laboratory of Developmental Signalling, Cancer Research UK London Research Institute, Lincoln's Inn Fields Laboratories, 44 Lincoln's Inn Fields, London WC2A 3PX, UK. E-mail: caroline.hill{at}cancer.org.uk

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Jun 2002	65	170	248
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Jul 2005	10	94	69
Aug 2005	19	84	63
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Nov 2005	48	110	85
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Feb 2007	35	78	64
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Apr 2008	37	92	72
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Jul 2008	68	90	64
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Nov 2008	140	143	165
Dec 2008	98	110	70
Jan 2009	106	146	75
Feb 2009	115	124	77
Mar 2009	180	152	102
Apr 2009	169	120	122
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Jun 2009	126	119	91
Jul 2009	156	133	81
Aug 2009	184	115	85
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Jan 2010	231	116	94
Feb 2010	256	126	80
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May 2010	213	147	86
Jun 2010	169	175	88
Jul 2010	188	149	95
Aug 2010	234	135	106
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Oct 2010	213	130	99
Nov 2010	240	145	112
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Jan 2011	209	143	91
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Jun 2011	182	150	106
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Aug 2011	194	145	143
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Oct 2011	244	173	125
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Nov 2012	115	166	123
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Jun 2013	100	164	114
Jul 2013	119	144	110
Aug 2013	127	85	92
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Nov 2013	138	178	125
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Apr 2014	130	207	125
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Jun 2014	125	194	110
Jul 2014	110	204	102
Aug 2014	88	153	93
Sep 2014	91	205	117
Oct 2014	118	258	102
Nov 2014	128	216	84
Dec 2014	159	168	80
Jan 2015	104	180	87
Feb 2015	94	222	95
Mar 2015	147	232	385
Apr 2015	177	259	113
May 2015	170	282	132
Jun 2015	151	244	108
Jul 2015	141	204	82
Aug 2015	103	153	75
Sep 2015	103	141	88
Oct 2015	114	191	138
Nov 2015	87	186	77
Dec 2015	91	185	78
Jan 2016	163	194	84
Feb 2016	219	168	68
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Apr 2016	139	240	102
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Jun 2016	129	193	76
Jul 2016	99	225	114
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Nov 2016	50	366	113
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Feb 2017	30	241	83
Mar 2017	23	321	80
Apr 2017	16	223	45
May 2017	16	226	72
Jun 2017	17	155	49
Jul 2017	26	191	63
Aug 2017	16	262	67
Sep 2017	19	246	66
Oct 2017	16	203	70
Nov 2017	12	246	60
Dec 2017	17	217	57
Jan 2018	13	270	85
Feb 2018	18	155	68
Mar 2018	20	239	83
Apr 2018	22	367	70
May 2018	22	211	86
Jun 2018	12	199	69
Jul 2018	14	168	84
Aug 2018	16	194	73
Sep 2018	7	178	54
Oct 2018	20	159	66
Nov 2018	20	200	76
Dec 2018	168	77	49
Jan 2019	229	68	27
Feb 2019	253	65	34
Mar 2019	215	67	28
Apr 2019	332	79	37
May 2019	244	73	30
Jun 2019	186	49	25
Jul 2019	200	71	28
Aug 2019	249	104	26
Sep 2019	330	101	15
Oct 2019	198	108	37
Nov 2019	242	59	19
Dec 2019	179	50	23
Jan 2020	256	86	30
Feb 2020	201	51	18
Mar 2020	249	50	24
Apr 2020	217	40	19
May 2020	214	42	26
Jun 2020	122	30	10
Jul 2020	137	38	20
Aug 2020	122	40	18
Sep 2020	147	34	11
Oct 2020	150	28	11
Nov 2020	166	34	16
Dec 2020	221	34	11
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Feb 2021	187	50	20
Mar 2021	299	64	39
Apr 2021	226	44	12
May 2021	252	28	12
Jun 2021	185	56	24
Jul 2021	146	50	15
Aug 2021	205	31	9
Sep 2021	155	66	21
Oct 2021	155	49	27
Nov 2021	201	49	25
Dec 2021	173	34	13
Jan 2022	214	36	15
Feb 2022	229	40	25
Mar 2022	248	53	27
Apr 2022	223	47	23
May 2022	170	46	23