Table of Contents

Articles

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  Fusion Proteins with Anticoagulant and Fibrinolytic Properties: Functional Studies and Structural Considerations

  Christian Icke, Bernhard Schlott, Oliver Ohlenschläger, Manfred Hartmann, Karl-Heinz Gührs and Erika Glusa

  Molecular Pharmacology August 2002, 62 (2) 203-209; DOI: https://doi.org/10.1124/mol.62.2.203
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  The Ca²⁺ Channel Antagonists Mibefradil and Pimozide Inhibit Cell Growth via Different Cytotoxic Mechanisms

  Gabriel E. Bertolesi, Chanjuan Shi, Lindsy Elbaum, Christine Jollimore, Gabriela Rozenberg, Steven Barnes and Melanie E. M. Kelly

  Molecular Pharmacology August 2002, 62 (2) 210-219; DOI: https://doi.org/10.1124/mol.62.2.210
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  Re-engineering Butyrylcholinesterase as a Cocaine Hydrolase

  Hong Sun, Yuan-Ping Pang, Oksana Lockridge and Stephen Brimijoin

  Molecular Pharmacology August 2002, 62 (2) 220-224; DOI: https://doi.org/10.1124/mol.62.2.220
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  Insulin-Like Growth Factor-1–Induced Phosphorylation of Transcription Factor FKHRL1 Is Mediated by Phosphatidylinositol 3-Kinase/Akt Kinase and Role of This Pathway in Insulin-Like Growth Factor-1–Induced Survival of Cultured Hippocampal Neurons

  Wen-Hua Zheng, Satyabrata Kar and Rémi Quirion

  Molecular Pharmacology August 2002, 62 (2) 225-233; DOI: https://doi.org/10.1124/mol.62.2.225
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  The Zebrafish (Danio rerio) Aryl Hydrocarbon Receptor Type 1 Is a Novel Vertebrate Receptor

  Eric A. Andreasen, Mark E. Hahn, Warren Heideman, Richard E. Peterson and Robert L. Tanguay

  Molecular Pharmacology August 2002, 62 (2) 234-249; DOI: https://doi.org/10.1124/mol.62.2.234
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  Cyclic AMP-Mediated Inhibition of 5-Lipoxygenase Translocation and Leukotriene Biosynthesis in Human Neutrophils

  Nicolas Flamand, Marc E. Surette, Serge Picard, Sylvain Bourgoin and Pierre Borgeat

  Molecular Pharmacology August 2002, 62 (2) 250-256; DOI: https://doi.org/10.1124/mol.62.2.250
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  Apoptosis in Murine Hepatoma Hepa 1c1c7 Wild-Type, C12, and C4 Cells Mediated by Bilirubin

  John M. Seubert, Alison J. Darmon, Ayman O. S. El-Kadi, Sudhir J. A. D'Souza and John R. Bend

  Molecular Pharmacology August 2002, 62 (2) 257-264; DOI: https://doi.org/10.1124/mol.62.2.257
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  Molecular Requisites for Drug Binding to Muscle CLC-1 and Renal CLC-K Channel Revealed by the Use of Phenoxy-Alkyl Derivatives of 2-(p-Chlorophenoxy)Propionic Acid

  Antonella Liantonio, Alessio Accardi, Giuseppe Carbonara, Giuseppe Fracchiolla, Fulvio Loiodice, Paolo Tortorella, Sonia Traverso, Patrizia Guida, Sabata Pierno, Annamaria De Luca, Diana Conte Camerino and Michael Pusch

  Molecular Pharmacology August 2002, 62 (2) 265-271; DOI: https://doi.org/10.1124/mol.62.2.265
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  Ethanol Induces Gene Expression via Nuclear Compartmentalization of Receptor for Activated C Kinase 1

  Dao-Yao He, Alicia J. Vagts, Rami Yaka and Dorit Ron

  Molecular Pharmacology August 2002, 62 (2) 272-280; DOI: https://doi.org/10.1124/mol.62.2.272
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  Negative and Positive Regulatory Epitopes in the C-Terminal Domains of the Human B1 and B2 Bradykinin Receptor Subtypes Determine Receptor Coupling Efficacy to G_9/11-Mediated Phospholipase Cβ Activity

  Dong Soo Kang and L. M. Fredrik Leeb-Lundberg

  Molecular Pharmacology August 2002, 62 (2) 281-288; DOI: https://doi.org/10.1124/mol.62.2.281
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  Inhibition of Branched-Chain α-Keto Acid Dehydrogenase Kinase and Sln1 Yeast Histidine Kinase by the Antifungal Antibiotic Radicicol

  Paul G. Besant, Michael V. Lasker, Cuong D. Bui and Christoph W. Turck

  Molecular Pharmacology August 2002, 62 (2) 289-296; DOI: https://doi.org/10.1124/mol.62.2.289
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  trans-Activation and Repression Properties of the Novel Nonsteroid Glucocorticoid Receptor Ligand 2,5-Dihydro-9-hydroxy-10-methoxy-2,2,4-trimethyl-5-(1-methylcyclohexen-3-y1)-1H-[1]benzopyrano[3,4-f]quinoline (A276575) and Its Four Stereoisomers

  Chun Wel Lin, Masaki Nakane, Mike Stashko, Doug Falls, Jane Kuk, Loan Miller, Ruth Huang, Curtis Tyree, Jeffrey N. Miner, John Rosen, Philip R. Kym, Mike J. Coghlan, George Carter and Ben C. Lane

  Molecular Pharmacology August 2002, 62 (2) 297-303; DOI: https://doi.org/10.1124/mol.62.2.297
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  Influence of Ceramide Metabolism on P-Glycoprotein Function in Immature Acute Myeloid Leukemia KG1a Cells

  Isabelle Plo, Gustav Lehne, Karen Johanne Beckstrøm, Nicolas Maestre, Ali Bettaı̈eb, Guy Laurent and Dominique Lautier

  Molecular Pharmacology August 2002, 62 (2) 304-312; DOI: https://doi.org/10.1124/mol.62.2.304
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  7,12-Dimethylbenz[a]anthracene Induces Apoptosis in Murine Pre-B Cells through a Caspase-8–Dependent Pathway

  Todd J. Page, Scott O'Brien, Colin R. Jefcoate and Charles J. Czuprynski

  Molecular Pharmacology August 2002, 62 (2) 313-319; DOI: https://doi.org/10.1124/mol.62.2.313
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  Alternative Processing of the Human FMO6 Gene Renders Transcripts Incapable of Encoding a Functional Flavin-Containing Monooxygenase

  Ronald N. Hines, Kathleen A. Hopp, Jose Franco, Kia Saeian and Frank P. Begun

  Molecular Pharmacology August 2002, 62 (2) 320-325; DOI: https://doi.org/10.1124/mol.62.2.320
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  Transcriptional Regulation of Basal Cyclooxygenase-2 Expression in Murine Lung Tumor-Derived Cell Lines by CCAAT/Enhancer-Binding Protein and Activating Transcription Factor/cAMP Response Element-Binding Protein

  Sarah A. Wardlaw, Na Zhang and Steven A. Belinsky

  Molecular Pharmacology August 2002, 62 (2) 326-333; DOI: https://doi.org/10.1124/mol.62.2.326
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  A Polymorphism in the Mouse Neuronal α4 Nicotinic Receptor Subunit Results in An Alteration in Receptor Function

  Peter Dobelis, Michael J. Marks, Paul Whiteaker, Seth A. Balogh, Allan C. Collins and Jerry A. Stitzel

  Molecular Pharmacology August 2002, 62 (2) 334-342; DOI: https://doi.org/10.1124/mol.62.2.334
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  The Intracellular Loops of the GB2 Subunit Are Crucial for G-Protein Coupling of the Heteromeric γ-Aminobutyrate B Receptor

  Michaela Havlickova, Laurent Prezeau, Beatrice Duthey, Bernhard Bettler, Jean-Philippe Pin and Jaroslav Blahos

  Molecular Pharmacology August 2002, 62 (2) 343-350; DOI: https://doi.org/10.1124/mol.62.2.343
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  Pharmacophore Model for Novel Inhibitors of Ubiquitin Isopeptidases That Induce p53-Independent Cell Death

  J. E. Mullally and F. A. Fitzpatrick

  Molecular Pharmacology August 2002, 62 (2) 351-358; DOI: https://doi.org/10.1124/mol.62.2.351
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  Transcriptional Regulation of the Human CYP3A4Gene by the Constitutive Androstane Receptor

  Bryan Goodwin, Ecushla Hodgson, Daniel J. D'Costa, Graham R. Robertson and Christopher Liddle

  Molecular Pharmacology August 2002, 62 (2) 359-365; DOI: https://doi.org/10.1124/mol.62.2.359
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  Modulation of Mouse and Human Phenobarbital-Responsive Enhancer Module by Nuclear Receptors

  Janne Mäkinen, Christian Frank, Johanna Jyrkkärinne, Jukka Gynther, Carsten Carlberg and Paavo Honkakoski

  Molecular Pharmacology August 2002, 62 (2) 366-378; DOI: https://doi.org/10.1124/mol.62.2.366
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  Oxidative Stress Decreases G Protein-Coupled Receptor Kinase 2 in Lymphocytes via a Calpain-Dependent Mechanism

  Maria Stella Lombardi, Annemieke Kavelaars, Petronila Penela, Elisabeth J. Scholtens, Marta Roccio, Reinhold E. Schmidt, Manfred Schedlowski, Federico Mayor and Cobi J. Heijnen

  Molecular Pharmacology August 2002, 62 (2) 379-388; DOI: https://doi.org/10.1124/mol.62.2.379
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  Behavioral Characterization of Mice Lacking Histamine H₃ Receptors

  Hiroshi Toyota, Christine Dugovic, Muriel Koehl, Aaron D. Laposky, China Weber, Karen Ngo, Ying Wu, Doo Hyun Lee, Kazuhiko Yanai, Eiko Sakurai, Takehiko Watanabe, Changlu Liu, Jingcai Chen, Ann J. Barbier, Fred W. Turek, Wai-Ping Fung-Leung and Timothy W. Lovenberg

  Molecular Pharmacology August 2002, 62 (2) 389-397; DOI: https://doi.org/10.1124/mol.62.2.389
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  Destabilization of the HIV-1 Reverse Transcriptase Dimer upon Interaction with N-Acyl Hydrazone Inhibitors

  Nicolas Sluis-Cremer, Dominique Arion and Michael A. Parniak

  Molecular Pharmacology August 2002, 62 (2) 398-405; DOI: https://doi.org/10.1124/mol.62.2.398
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  Nicotinic Receptor M3 Transmembrane Domain: Position 8′ Contributes to Channel Gating

  María José De Rosa, Diego Rayes, Guillermo Spitzmaul and Cecilia Bouzat

  Molecular Pharmacology August 2002, 62 (2) 406-414; DOI: https://doi.org/10.1124/mol.62.2.406
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  Prenylamine Block of Nav1.5 Channel is Mediated via a Receptor Distinct from That of Local Anesthetics

  Mustafa G. Mujtaba, Sho-Ya Wang and Ging Kuo Wang

  Molecular Pharmacology August 2002, 62 (2) 415-422; DOI: https://doi.org/10.1124/mol.62.2.415
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  Inflammation Modulates the Interaction of Heterogeneous Nuclear Ribonucleoprotein (hnRNP) I/Polypyrimidine Tract Binding Protein and hnRNP L with the 3′Untranslated Region of the Murine Inducible Nitric-Oxide Synthase mRNA

  Malin Söderberg, Françoise Raffalli-Mathieu and Matti A. Lang

  Molecular Pharmacology August 2002, 62 (2) 423-431; DOI: https://doi.org/10.1124/mol.62.2.423