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Molecular Pharmacology

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Table of Contents

September 01, 2002; Volume 62,Issue 3

Accelerated Communications

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    Inhibition of Tetrodotoxin (TTX)-Resistant and TTX-Sensitive Neuronal Na+ Channels by the Secretolytic Ambroxol
    Thomas Weiser and Nicola Wilson
    Molecular Pharmacology September 2002, 62 (3) 433-438; DOI: https://doi.org/10.1124/mol.62.3.433
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    Development of A Real-Time in Vivo Transcription Assay: Application Reveals Pregnane X Receptor-Mediated Induction of CYP3A4 by Cancer Chemotherapeutic Agents
    Erin Schuetz, Lubin Lan, Kazuto Yasuda, Richard Kim, Thomas A. Kocarek, John Schuetz and Stephen Strom
    Molecular Pharmacology September 2002, 62 (3) 439-445; DOI: https://doi.org/10.1124/mol.62.3.439

Perspectives

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    Pharmacogenomics of Human UDP-Glucuronosyltransferases and Irinotecan Toxicity
    Robert H. Tukey, Christian P. Strassburg and Peter I. Mackenzie
    Molecular Pharmacology September 2002, 62 (3) 446-450; DOI: https://doi.org/10.1124/mol.62.3.446
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    Measures of Efficacy Using G Proteins as Endpoints: Differential Engagement of G Proteins through Single Receptors
    David R. Manning
    Molecular Pharmacology September 2002, 62 (3) 451-452; DOI: https://doi.org/10.1124/mol.62.3.451

Articles

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    Depletion of Intracellular GTP Results in Nuclear Factor-κB Activation and Intercellular Adhesion Molecule-1 Expression in Human Endothelial Cells
    G. Weigel, P. Bertalanffy and E. Wolner
    Molecular Pharmacology September 2002, 62 (3) 453-462; DOI: https://doi.org/10.1124/mol.62.3.453
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    A77 1726 Induces Differentiation of Human Myeloid Leukemia K562 Cells by Depletion of Intracellular CTP Pools
    Min Huang, Yanhong Wang, Matthew Collins, Beverly S. Mitchell and Lee M. Graves
    Molecular Pharmacology September 2002, 62 (3) 463-472; DOI: https://doi.org/10.1124/mol.62.3.463
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    Glutamate Cascade to cAMP Response Element-Binding Protein Phosphorylation in Cultured Striatal Neurons through Calcium-Coupled Group I Metabotropic Glutamate Receptors
    Limin Mao and John Q. Wang
    Molecular Pharmacology September 2002, 62 (3) 473-484; DOI: https://doi.org/10.1124/mol.62.3.473
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    Molecular Cloning and Characterization of the Human Voltage-Gated Calcium Channel α2δ-4 Subunit
    Ning Qin, Susan Yagel, Mary-Lou Momplaisir, Ellen E. Codd and Michael R. D'Andrea
    Molecular Pharmacology September 2002, 62 (3) 485-496; DOI: https://doi.org/10.1124/mol.62.3.485
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    Vascular Smooth Muscle Cell Phosphodiesterase (PDE) 3 and PDE4 Activities and Levels are Regulated by Cyclic AMP in Vivo
    Douglas G. Tilley and Donald H. Maurice
    Molecular Pharmacology September 2002, 62 (3) 497-506; DOI: https://doi.org/10.1124/mol.62.3.497
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    D2 and D3 Dopamine Receptor Cell Surface Localization Mediated by Interaction with Protein 4.1N
    Alicia V. Binda, Nadine Kabbani, Ridwan Lin and Robert Levenson
    Molecular Pharmacology September 2002, 62 (3) 507-513; DOI: https://doi.org/10.1124/mol.62.3.507
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    Identification of Interaction Sites of Cyclic Nucleotide Phosphodiesterase Type 3A with Milrinone and Cilostazol Using Molecular Modeling and Site-Directed Mutagenesis
    W. Zhang, H. Ke and R. W. Colman
    Molecular Pharmacology September 2002, 62 (3) 514-520; DOI: https://doi.org/10.1124/mol.62.3.514
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    A Fusion Protein of the Human P2Y1 Receptor and NTPDase1 Exhibits Functional Activities of the Native Receptor and Ectoenzyme and Reduced Signaling Responses to Endogenously Released Nucleotides
    Claudia Alvarado-Castillo, Patricia Lozano-Zarain, Jesús Mateo, T. Kendall Harden and José L. Boyer
    Molecular Pharmacology September 2002, 62 (3) 521-528; DOI: https://doi.org/10.1124/mol.62.3.521
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    Arsenic Trioxide Produces Polymerization of Microtubules and Mitotic Arrest before Apoptosis in Human Tumor Cell Lines
    Yi-He Ling, Jian-Dong Jiang, James F. Holland and Roman Perez-Soler
    Molecular Pharmacology September 2002, 62 (3) 529-538; DOI: https://doi.org/10.1124/mol.62.3.529
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    Blockade of Nitric-Oxide Synthase Reduces Choroidal Neovascularization
    Akira Ando, Amy Yang, Hiroyuki Nambu and Peter A. Campochiaro
    Molecular Pharmacology September 2002, 62 (3) 539-544; DOI: https://doi.org/10.1124/mol.62.3.539
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    Restoration of Human β-Globin Gene Expression in Murine and Human IVS2–654 Thalassemic Erythroid Cells by Free Uptake of Antisense Oligonucleotides
    Thipparat Suwanmanee, Halina Sierakowska, Giuseppina Lacerra, Saovaros Svasti, Suzanne Kirby, Christopher E. Walsh, Suthat Fucharoen and Ryszard Kole
    Molecular Pharmacology September 2002, 62 (3) 545-553; DOI: https://doi.org/10.1124/mol.62.3.545
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    Genistein Inhibits Cardiac L-Type Ca2+ Channel Activity by a Tyrosine Kinase-Independent Mechanism
    Andriy E. Belevych, Sunita Warrier and Robert D. Harvey
    Molecular Pharmacology September 2002, 62 (3) 554-565; DOI: https://doi.org/10.1124/mol.62.3.554
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    Effects of 5′-Alkyl-Benzothiadiazides on (R,S)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Biophysics and Synaptic Responses
    Amy C. Arai, Yan-Fang Xia, Markus Kessler, Dean Phillips, Richard Chamberlin, Richard Granger and Gary Lynch
    Molecular Pharmacology September 2002, 62 (3) 566-577; DOI: https://doi.org/10.1124/mol.62.3.566
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    Differential Activation of Gq/11 and Gi3 Proteins at 5-Hydroxytryptamine2C Receptors Revealed by Antibody Capture Assays: Influence of Receptor Reserve and Relationship to Agonist-Directed Trafficking
    Didier Cussac, Adrian Newman-Tancredi, Delphine Duqueyroix, Valérie Pasteau and Mark J. Millan
    Molecular Pharmacology September 2002, 62 (3) 578-589; DOI: https://doi.org/10.1124/mol.62.3.578
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    Antibody Capture Assay Reveals Bell-Shaped Concentration-Response Isotherms for h5-HT1A Receptor-Mediated Gαi3Activation: Conformational Selection by High-Efficacy Agonists, and Relationship to Trafficking of Receptor Signaling
    Adrian Newman-Tancredi, Didier Cussac, Laetitia Marini and Mark J. Millan
    Molecular Pharmacology September 2002, 62 (3) 590-601; DOI: https://doi.org/10.1124/mol.62.3.590
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    Inhibitory Effect of Fluvastatin on Lysophosphatidylcholine-Induced Nonselective Cation Current in Guinea Pig Ventricular Myocytes
    Libing Li, Isao Matsuoka, Yuichi Suzuki, Yasuhide Watanabe, Toshiyuki Ishibashi, Keiko Yokoyama, Yukio Maruyama and Junko Kimura
    Molecular Pharmacology September 2002, 62 (3) 602-607; DOI: https://doi.org/10.1124/mol.62.3.602
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    Common Human UGT1A Polymorphisms and the Altered Metabolism of Irinotecan Active Metabolite 7-Ethyl-10-hydroxycamptothecin (SN-38)
    Jean-François Gagné, Valerie Montminy, Patrick Belanger, Kim Journault, Genevieve Gaucher and Chantal Guillemette
    Molecular Pharmacology September 2002, 62 (3) 608-617; DOI: https://doi.org/10.1124/mol.62.3.608
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    A Reevaluation of Neuronal Zinc Measurements: Artifacts Associated with High Intracellular Dye Concentration
    Kirk E. Dineley, Latha M. Malaiyandi and Ian J. Reynolds
    Molecular Pharmacology September 2002, 62 (3) 618-627; DOI: https://doi.org/10.1124/mol.62.3.618
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    Covalent Binding of the Nitroso Metabolite of Sulfamethoxazole Leads to Toxicity and Major Histocompatibility Complex-Restricted Antigen Presentation
    Dean J. Naisbitt, John Farrell, S. Fraser Gordon, James L. Maggs, Christoph Burkhart, Werner J. Pichler, Munir Pirmohamed and B. Kevin Park
    Molecular Pharmacology September 2002, 62 (3) 628-637; DOI: https://doi.org/10.1124/mol.62.3.628
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    Nuclear Pregnane X Receptor and Constitutive Androstane Receptor Regulate Overlapping but Distinct Sets of Genes Involved in Xenobiotic Detoxification
    Jodi M. Maglich, Catherine M. Stoltz, Bryan Goodwin, Diane Hawkins-Brown, John T. Moore and Steven A. Kliewer
    Molecular Pharmacology September 2002, 62 (3) 638-646; DOI: https://doi.org/10.1124/mol.62.3.638
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    Neurotensin Induces Tyrosine Hydroxylase Gene Activation through Nitric Oxide and Protein Kinase C Signaling Pathways
    Mustapha Najimi, Jean-Jacques Robert, Jacques Mallet, William Rostène and Patricia Forgez
    Molecular Pharmacology September 2002, 62 (3) 647-653; DOI: https://doi.org/10.1124/mol.62.3.647
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    Characterization and Comparison of RGS2 and RGS4 as GTPase-Activating Proteins for m2 Muscarinic Receptor-Stimulated Gi
    Wendy Cladman and Peter Chidiac
    Molecular Pharmacology September 2002, 62 (3) 654-659; DOI: https://doi.org/10.1124/mol.62.3.654
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    Akt Activation Induced by Lysophosphatidic Acid and Sphingosine-1-phosphate Requires Both Mitogen-Activated Protein Kinase Kinase and p38 Mitogen-Activated Protein Kinase and Is Cell-Line Specific
    Linnea M. Baudhuin, Kelly L. Cristina, Jun Lu and Yan Xu
    Molecular Pharmacology September 2002, 62 (3) 660-671; DOI: https://doi.org/10.1124/mol.62.3.660
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    Activation of Phospholipase Cγ2 by Tyrosine Phosphorylation
    Fatih Özdener, Carol Dangelmaier, Barrie Ashby, Satya P. Kunapuli and James L. Daniel
    Molecular Pharmacology September 2002, 62 (3) 672-679; DOI: https://doi.org/10.1124/mol.62.3.672
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    Inhibition of Cyclin-Dependent Kinase 2 by the Chk1-Cdc25A Pathway during the S-Phase Checkpoint Activated by Fludarabine: Dysregulation by 7-Hydroxystaurosporine
    Deepa Sampath, Zheng Shi and William Plunkett
    Molecular Pharmacology September 2002, 62 (3) 680-688; DOI: https://doi.org/10.1124/mol.62.3.680
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    Regulation of Platinum-Compound Cytotoxicity by the c-Jun N-Terminal Kinase and c-Jun Signaling Pathway in Small-Cell Lung Cancer Cells
    Valerie Levresse, Lindsay Marek, Deborah Blumberg and Lynn E. Heasley
    Molecular Pharmacology September 2002, 62 (3) 689-697; DOI: https://doi.org/10.1124/mol.62.3.689
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    Dexamethasone Inhibits Inducible Nitric-Oxide Synthase Expression and Nitric Oxide Production by Destabilizing mRNA in Lipopolysaccharide-Treated Macrophages
    Riku Korhonen, Aleksi Lahti, Mari Hämäläinen, Hannu Kankaanranta and Eeva Moilanen
    Molecular Pharmacology September 2002, 62 (3) 698-704; DOI: https://doi.org/10.1124/mol.62.3.698
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    Mechanisms Underlying Tissue Selectivity of Anandamide and Other Vanilloid Receptor Agonists
    David A. Andersson, Mikael Adner, Edward D. Högestätt and Peter M. Zygmunt
    Molecular Pharmacology September 2002, 62 (3) 705-713; DOI: https://doi.org/10.1124/mol.62.3.705
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    Role of the Human Herpesvirus 6 U69-Encoded Kinase in the Phosphorylation of Ganciclovir
    Leen De Bolle, Detlef Michel, Thomas Mertens, Chaysavanh Manichanh, Henri Agut, Erik De Clercq and Lieve Naesens
    Molecular Pharmacology September 2002, 62 (3) 714-721; DOI: https://doi.org/10.1124/mol.62.3.714
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    2,3,7,8-Tetrachlorodibenzo-p-dioxin Suppresses Tumor Necrosis Factor-α and Anti-CD40–Induced Activation of NF-κB/Rel in Dendritic Cells: p50 Homodimer Activation Is Not Affected
    Carl E. Ruby, Mark Leid and Nancy I. Kerkvliet
    Molecular Pharmacology September 2002, 62 (3) 722-728; DOI: https://doi.org/10.1124/mol.62.3.722
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    Identification of the Extracellular Loop 2 as the Point of Interaction between the N Terminus of the Chemokine MIP-1α and Its CCR1 Receptor
    Sannah Zoffmann, André Chollet and Jean-Luc Galzi
    Molecular Pharmacology September 2002, 62 (3) 729-736; DOI: https://doi.org/10.1124/mol.62.3.729
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    Regulation of Human CYP2C9 by the Constitutive Androstane Receptor: Discovery of a New Distal Binding Site
    Stephen S. Ferguson, Edward L. LeCluyse, Masahiko Negishi and Joyce A. Goldstein
    Molecular Pharmacology September 2002, 62 (3) 737-746; DOI: https://doi.org/10.1124/mol.62.3.737
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    Generation and Analysis of Constitutively Active and Physically Destabilized Mutants of the Human β1-Adrenoceptor
    Alison J. McLean, Fu-Yue Zeng, Dominic Behan, Derek Chalmers and Graeme Milligan
    Molecular Pharmacology September 2002, 62 (3) 747-755; DOI: https://doi.org/10.1124/mol.62.3.747
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    Effects of Phosphoinositide 3-Kinase on the Endothelin-1–Induced Activation of Voltage-Independent Ca2+ Channels and Mitogenesis in Chinese Hamster Ovary Cells Stably Expressing EndothelinA Receptor
    Yoshifumi Kawanabe, Nobuo Hashimoto and Tomoh Masaki
    Molecular Pharmacology September 2002, 62 (3) 756-761; DOI: https://doi.org/10.1124/mol.62.3.756

Errata

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    Correction to “Negative and positive regulatory epitopes in the C-terminal domains of the human B1 and B2 bradykinin receptor subtypes determine receptor coupling efficacy to G9/11-mediated phospholipase Cβ activity ”
    Molecular Pharmacology September 2002, 62 (3) 762; DOI: https://doi.org/10.1124/mol.62.3.762
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    Correction to “Behavioral characterization of mice lacking histamine H3 receptors”
    Molecular Pharmacology September 2002, 62 (3) 763; DOI: https://doi.org/10.1124/mol.62.3.763
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Molecular Pharmacology: 62 (3)
Molecular Pharmacology
Vol. 62, Issue 3
1 Sep 2002
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