Table of Contents

Articles

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  Depletion of Intracellular GTP Results in Nuclear Factor-κB Activation and Intercellular Adhesion Molecule-1 Expression in Human Endothelial Cells

  G. Weigel, P. Bertalanffy and E. Wolner

  Molecular Pharmacology September 2002, 62 (3) 453-462; DOI: https://doi.org/10.1124/mol.62.3.453
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  A77 1726 Induces Differentiation of Human Myeloid Leukemia K562 Cells by Depletion of Intracellular CTP Pools

  Min Huang, Yanhong Wang, Matthew Collins, Beverly S. Mitchell and Lee M. Graves

  Molecular Pharmacology September 2002, 62 (3) 463-472; DOI: https://doi.org/10.1124/mol.62.3.463
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  Glutamate Cascade to cAMP Response Element-Binding Protein Phosphorylation in Cultured Striatal Neurons through Calcium-Coupled Group I Metabotropic Glutamate Receptors

  Limin Mao and John Q. Wang

  Molecular Pharmacology September 2002, 62 (3) 473-484; DOI: https://doi.org/10.1124/mol.62.3.473
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  Molecular Cloning and Characterization of the Human Voltage-Gated Calcium Channel α₂δ-4 Subunit

  Ning Qin, Susan Yagel, Mary-Lou Momplaisir, Ellen E. Codd and Michael R. D'Andrea

  Molecular Pharmacology September 2002, 62 (3) 485-496; DOI: https://doi.org/10.1124/mol.62.3.485
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  Vascular Smooth Muscle Cell Phosphodiesterase (PDE) 3 and PDE4 Activities and Levels are Regulated by Cyclic AMP in Vivo

  Douglas G. Tilley and Donald H. Maurice

  Molecular Pharmacology September 2002, 62 (3) 497-506; DOI: https://doi.org/10.1124/mol.62.3.497
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  D2 and D3 Dopamine Receptor Cell Surface Localization Mediated by Interaction with Protein 4.1N

  Alicia V. Binda, Nadine Kabbani, Ridwan Lin and Robert Levenson

  Molecular Pharmacology September 2002, 62 (3) 507-513; DOI: https://doi.org/10.1124/mol.62.3.507
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  Identification of Interaction Sites of Cyclic Nucleotide Phosphodiesterase Type 3A with Milrinone and Cilostazol Using Molecular Modeling and Site-Directed Mutagenesis

  W. Zhang, H. Ke and R. W. Colman

  Molecular Pharmacology September 2002, 62 (3) 514-520; DOI: https://doi.org/10.1124/mol.62.3.514
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  A Fusion Protein of the Human P2Y₁ Receptor and NTPDase1 Exhibits Functional Activities of the Native Receptor and Ectoenzyme and Reduced Signaling Responses to Endogenously Released Nucleotides

  Claudia Alvarado-Castillo, Patricia Lozano-Zarain, Jesús Mateo, T. Kendall Harden and José L. Boyer

  Molecular Pharmacology September 2002, 62 (3) 521-528; DOI: https://doi.org/10.1124/mol.62.3.521
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  Arsenic Trioxide Produces Polymerization of Microtubules and Mitotic Arrest before Apoptosis in Human Tumor Cell Lines

  Yi-He Ling, Jian-Dong Jiang, James F. Holland and Roman Perez-Soler

  Molecular Pharmacology September 2002, 62 (3) 529-538; DOI: https://doi.org/10.1124/mol.62.3.529
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  Blockade of Nitric-Oxide Synthase Reduces Choroidal Neovascularization

  Akira Ando, Amy Yang, Hiroyuki Nambu and Peter A. Campochiaro

  Molecular Pharmacology September 2002, 62 (3) 539-544; DOI: https://doi.org/10.1124/mol.62.3.539
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  Restoration of Human β-Globin Gene Expression in Murine and Human IVS2–654 Thalassemic Erythroid Cells by Free Uptake of Antisense Oligonucleotides

  Thipparat Suwanmanee, Halina Sierakowska, Giuseppina Lacerra, Saovaros Svasti, Suzanne Kirby, Christopher E. Walsh, Suthat Fucharoen and Ryszard Kole

  Molecular Pharmacology September 2002, 62 (3) 545-553; DOI: https://doi.org/10.1124/mol.62.3.545
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  Genistein Inhibits Cardiac L-Type Ca²⁺ Channel Activity by a Tyrosine Kinase-Independent Mechanism

  Andriy E. Belevych, Sunita Warrier and Robert D. Harvey

  Molecular Pharmacology September 2002, 62 (3) 554-565; DOI: https://doi.org/10.1124/mol.62.3.554
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  Effects of 5′-Alkyl-Benzothiadiazides on (R,S)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Biophysics and Synaptic Responses

  Amy C. Arai, Yan-Fang Xia, Markus Kessler, Dean Phillips, Richard Chamberlin, Richard Granger and Gary Lynch

  Molecular Pharmacology September 2002, 62 (3) 566-577; DOI: https://doi.org/10.1124/mol.62.3.566
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  Differential Activation of Gq/11 and Gi₃ Proteins at 5-Hydroxytryptamine_2C Receptors Revealed by Antibody Capture Assays: Influence of Receptor Reserve and Relationship to Agonist-Directed Trafficking

  Didier Cussac, Adrian Newman-Tancredi, Delphine Duqueyroix, Valérie Pasteau and Mark J. Millan

  Molecular Pharmacology September 2002, 62 (3) 578-589; DOI: https://doi.org/10.1124/mol.62.3.578
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  Antibody Capture Assay Reveals Bell-Shaped Concentration-Response Isotherms for h5-HT_1A Receptor-Mediated Gα_i3Activation: Conformational Selection by High-Efficacy Agonists, and Relationship to Trafficking of Receptor Signaling

  Adrian Newman-Tancredi, Didier Cussac, Laetitia Marini and Mark J. Millan

  Molecular Pharmacology September 2002, 62 (3) 590-601; DOI: https://doi.org/10.1124/mol.62.3.590
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  Inhibitory Effect of Fluvastatin on Lysophosphatidylcholine-Induced Nonselective Cation Current in Guinea Pig Ventricular Myocytes

  Libing Li, Isao Matsuoka, Yuichi Suzuki, Yasuhide Watanabe, Toshiyuki Ishibashi, Keiko Yokoyama, Yukio Maruyama and Junko Kimura

  Molecular Pharmacology September 2002, 62 (3) 602-607; DOI: https://doi.org/10.1124/mol.62.3.602
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  Common Human UGT1A Polymorphisms and the Altered Metabolism of Irinotecan Active Metabolite 7-Ethyl-10-hydroxycamptothecin (SN-38)

  Jean-François Gagné, Valerie Montminy, Patrick Belanger, Kim Journault, Genevieve Gaucher and Chantal Guillemette

  Molecular Pharmacology September 2002, 62 (3) 608-617; DOI: https://doi.org/10.1124/mol.62.3.608
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  A Reevaluation of Neuronal Zinc Measurements: Artifacts Associated with High Intracellular Dye Concentration

  Kirk E. Dineley, Latha M. Malaiyandi and Ian J. Reynolds

  Molecular Pharmacology September 2002, 62 (3) 618-627; DOI: https://doi.org/10.1124/mol.62.3.618
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  Covalent Binding of the Nitroso Metabolite of Sulfamethoxazole Leads to Toxicity and Major Histocompatibility Complex-Restricted Antigen Presentation

  Dean J. Naisbitt, John Farrell, S. Fraser Gordon, James L. Maggs, Christoph Burkhart, Werner J. Pichler, Munir Pirmohamed and B. Kevin Park

  Molecular Pharmacology September 2002, 62 (3) 628-637; DOI: https://doi.org/10.1124/mol.62.3.628
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  Nuclear Pregnane X Receptor and Constitutive Androstane Receptor Regulate Overlapping but Distinct Sets of Genes Involved in Xenobiotic Detoxification

  Jodi M. Maglich, Catherine M. Stoltz, Bryan Goodwin, Diane Hawkins-Brown, John T. Moore and Steven A. Kliewer

  Molecular Pharmacology September 2002, 62 (3) 638-646; DOI: https://doi.org/10.1124/mol.62.3.638
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  Neurotensin Induces Tyrosine Hydroxylase Gene Activation through Nitric Oxide and Protein Kinase C Signaling Pathways

  Mustapha Najimi, Jean-Jacques Robert, Jacques Mallet, William Rostène and Patricia Forgez

  Molecular Pharmacology September 2002, 62 (3) 647-653; DOI: https://doi.org/10.1124/mol.62.3.647
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  Characterization and Comparison of RGS2 and RGS4 as GTPase-Activating Proteins for m2 Muscarinic Receptor-Stimulated G_i

  Wendy Cladman and Peter Chidiac

  Molecular Pharmacology September 2002, 62 (3) 654-659; DOI: https://doi.org/10.1124/mol.62.3.654
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  Akt Activation Induced by Lysophosphatidic Acid and Sphingosine-1-phosphate Requires Both Mitogen-Activated Protein Kinase Kinase and p38 Mitogen-Activated Protein Kinase and Is Cell-Line Specific

  Linnea M. Baudhuin, Kelly L. Cristina, Jun Lu and Yan Xu

  Molecular Pharmacology September 2002, 62 (3) 660-671; DOI: https://doi.org/10.1124/mol.62.3.660
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  Activation of Phospholipase Cγ2 by Tyrosine Phosphorylation

  Fatih Özdener, Carol Dangelmaier, Barrie Ashby, Satya P. Kunapuli and James L. Daniel

  Molecular Pharmacology September 2002, 62 (3) 672-679; DOI: https://doi.org/10.1124/mol.62.3.672
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  Inhibition of Cyclin-Dependent Kinase 2 by the Chk1-Cdc25A Pathway during the S-Phase Checkpoint Activated by Fludarabine: Dysregulation by 7-Hydroxystaurosporine

  Deepa Sampath, Zheng Shi and William Plunkett

  Molecular Pharmacology September 2002, 62 (3) 680-688; DOI: https://doi.org/10.1124/mol.62.3.680
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  Regulation of Platinum-Compound Cytotoxicity by the c-Jun N-Terminal Kinase and c-Jun Signaling Pathway in Small-Cell Lung Cancer Cells

  Valerie Levresse, Lindsay Marek, Deborah Blumberg and Lynn E. Heasley

  Molecular Pharmacology September 2002, 62 (3) 689-697; DOI: https://doi.org/10.1124/mol.62.3.689
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  Dexamethasone Inhibits Inducible Nitric-Oxide Synthase Expression and Nitric Oxide Production by Destabilizing mRNA in Lipopolysaccharide-Treated Macrophages

  Riku Korhonen, Aleksi Lahti, Mari Hämäläinen, Hannu Kankaanranta and Eeva Moilanen

  Molecular Pharmacology September 2002, 62 (3) 698-704; DOI: https://doi.org/10.1124/mol.62.3.698
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  Mechanisms Underlying Tissue Selectivity of Anandamide and Other Vanilloid Receptor Agonists

  David A. Andersson, Mikael Adner, Edward D. Högestätt and Peter M. Zygmunt

  Molecular Pharmacology September 2002, 62 (3) 705-713; DOI: https://doi.org/10.1124/mol.62.3.705
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  Role of the Human Herpesvirus 6 U69-Encoded Kinase in the Phosphorylation of Ganciclovir

  Leen De Bolle, Detlef Michel, Thomas Mertens, Chaysavanh Manichanh, Henri Agut, Erik De Clercq and Lieve Naesens

  Molecular Pharmacology September 2002, 62 (3) 714-721; DOI: https://doi.org/10.1124/mol.62.3.714
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  2,3,7,8-Tetrachlorodibenzo-p-dioxin Suppresses Tumor Necrosis Factor-α and Anti-CD40–Induced Activation of NF-κB/Rel in Dendritic Cells: p50 Homodimer Activation Is Not Affected

  Carl E. Ruby, Mark Leid and Nancy I. Kerkvliet

  Molecular Pharmacology September 2002, 62 (3) 722-728; DOI: https://doi.org/10.1124/mol.62.3.722
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  Identification of the Extracellular Loop 2 as the Point of Interaction between the N Terminus of the Chemokine MIP-1α and Its CCR1 Receptor

  Sannah Zoffmann, André Chollet and Jean-Luc Galzi

  Molecular Pharmacology September 2002, 62 (3) 729-736; DOI: https://doi.org/10.1124/mol.62.3.729
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  Regulation of Human CYP2C9 by the Constitutive Androstane Receptor: Discovery of a New Distal Binding Site

  Stephen S. Ferguson, Edward L. LeCluyse, Masahiko Negishi and Joyce A. Goldstein

  Molecular Pharmacology September 2002, 62 (3) 737-746; DOI: https://doi.org/10.1124/mol.62.3.737
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  Generation and Analysis of Constitutively Active and Physically Destabilized Mutants of the Human β₁-Adrenoceptor

  Alison J. McLean, Fu-Yue Zeng, Dominic Behan, Derek Chalmers and Graeme Milligan

  Molecular Pharmacology September 2002, 62 (3) 747-755; DOI: https://doi.org/10.1124/mol.62.3.747
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  Effects of Phosphoinositide 3-Kinase on the Endothelin-1–Induced Activation of Voltage-Independent Ca²⁺ Channels and Mitogenesis in Chinese Hamster Ovary Cells Stably Expressing Endothelin_A Receptor

  Yoshifumi Kawanabe, Nobuo Hashimoto and Tomoh Masaki

  Molecular Pharmacology September 2002, 62 (3) 756-761; DOI: https://doi.org/10.1124/mol.62.3.756