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Research ArticleArticle

Covalent Binding of the Nitroso Metabolite of Sulfamethoxazole Leads to Toxicity and Major Histocompatibility Complex-Restricted Antigen Presentation

Dean J. Naisbitt, John Farrell, S. Fraser Gordon, James L. Maggs, Christoph Burkhart, Werner J. Pichler, Munir Pirmohamed and B. Kevin Park
Molecular Pharmacology September 2002, 62 (3) 628-637; DOI: https://doi.org/10.1124/mol.62.3.628

Article Information

vol. 62 no. 3 628-637
DOI 
https://doi.org/10.1124/mol.62.3.628
PubMed 
12181439
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received February 11, 2002
  • Accepted May 22, 2002
  • Published online September 1, 2002.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Dean J. Naisbitt1,
  2. John Farrell1,
  3. S. Fraser Gordon1,
  4. James L. Maggs1,
  5. Christoph Burkhart2,
  6. Werner J. Pichler2,
  7. Munir Pirmohamed1, and
  8. B. Kevin Park1
  1. 1Department of Pharmacology and Therapeutics, The University of Liverpool, Liverpool, United Kingdom (D.J.N., J.F., S.F.G., J.L.M., M.P., B.K.P.); and 2Clinic of Rheumatology and Clinical Immunology/Allergology, Inselspital, University Bern, Bern, Switzerland (C.B., W.J.P.)
  1. Dr. Dean J. Naisbitt, Department of Pharmacology and Therapeutics, Ashton Street Medical Building, The University of Liverpool, P.O. Box 147, Liverpool L69 3BX, UK. E-mail:dnes{at}liv.ac.uk
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Research ArticleArticle

Covalent Binding of the Nitroso Metabolite of Sulfamethoxazole Leads to Toxicity and Major Histocompatibility Complex-Restricted Antigen Presentation

Dean J. Naisbitt, John Farrell, S. Fraser Gordon, James L. Maggs, Christoph Burkhart, Werner J. Pichler, Munir Pirmohamed and B. Kevin Park
Molecular Pharmacology September 1, 2002, 62 (3) 628-637; DOI: https://doi.org/10.1124/mol.62.3.628
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