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Research ArticleArticle

Cell-Level Pharmacokinetic Model of Granulocyte Colony-Stimulating Factor: Implications for Ligand Lifetime and Potency in Vivo

Casim A. Sarkar and Douglas A. Lauffenburger
Molecular Pharmacology January 2003, 63 (1) 147-158; DOI: https://doi.org/10.1124/mol.63.1.147

Article Information

vol. 63 no. 1 147-158
DOI 
https://doi.org/10.1124/mol.63.1.147
PubMed 
12488547
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received July 11, 2002
  • Accepted October 4, 2002
  • Published online January 1, 2003.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Casim A. Sarkar1,1,2 and
  2. Douglas A. Lauffenburger1,2,3,4
  1. 1Department of Chemical Engineering (C.A.S., D.A.L.), 2Biotechnology Process Engineering Center (C.A.S., D.A.L.), 3Department of Biology (D.A.L.), and 4Biological Engineering Division (D.A.L.), Massachusetts Institute of Technology, Cambridge, Massachusetts
  1. Douglas A. Lauffenburger, Massachusetts Institute of Technology, Room 56–341, Cambridge, Massachusetts 02139-4307. E-mail: lauffen{at}mit.edu
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Research ArticleArticle

Cell-Level Pharmacokinetic Model of Granulocyte Colony-Stimulating Factor: Implications for Ligand Lifetime and Potency in Vivo

Casim A. Sarkar and Douglas A. Lauffenburger
Molecular Pharmacology January 1, 2003, 63 (1) 147-158; DOI: https://doi.org/10.1124/mol.63.1.147
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