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Research ArticleArticle

Molecular Basis of Partial Agonism: Orientation of Indoleamine Ligands in the Binding Pocket of the Human Serotonin 5-HT2A Receptor Determines Relative Efficacy

Barbara J. Ebersole, Irache Visiers, Harel Weinstein and Stuart C. Sealfon
Molecular Pharmacology January 2003, 63 (1) 36-43; DOI: https://doi.org/10.1124/mol.63.1.36

Article Information

vol. 63 no. 1 36-43
DOI 
https://doi.org/10.1124/mol.63.1.36
PubMed 
12488534
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received August 8, 2002
  • Accepted October 11, 2002
  • Published online January 1, 2003.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Barbara J. Ebersole1,
  2. Irache Visiers2,
  3. Harel Weinstein2,3, and
  4. Stuart C. Sealfon1,3,4
  1. Departments of 1Neurology (B.J.E., S.C.S.), 2Physiology and Biophysics (I.V., H.W.), 3Pharmacology and Biological Chemistry (H.W., S.C.S.), and the 4Fishberg Research Center in Neurobiology (S.C.S.), Mount Sinai School of Medicine, New York, New York
  1. Harel Weinstein, D.Sc., Department of Physiology and Biophysics, Box 1218, Mt. Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029. E-mail:harel.weinstein{at}mssm.edu
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Research ArticleArticle

Molecular Basis of Partial Agonism: Orientation of Indoleamine Ligands in the Binding Pocket of the Human Serotonin 5-HT2A Receptor Determines Relative Efficacy

Barbara J. Ebersole, Irache Visiers, Harel Weinstein and Stuart C. Sealfon
Molecular Pharmacology January 1, 2003, 63 (1) 36-43; DOI: https://doi.org/10.1124/mol.63.1.36
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