Table of Contents

Articles

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  Differential Requirement of Gα₁₂, Gα₁₃, Gα_q, and Gβγ for Endothelin-1-Induced c-Jun NH₂-Terminal Kinase and Extracellular Signal-Regulated Kinase Activation

  Ken Arai, Yoshiko Maruyama, Motohiro Nishida, Shihori Tanabe, Shuichi Takagahara, Tohru Kozasa, Yasuo Mori, Taku Nagao and Hitoshi Kurose

  Molecular Pharmacology March 2003, 63 (3) 478-488; DOI: https://doi.org/10.1124/mol.63.3.478
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  Influence of Molecular Structure on Substrate Binding to the Human Organic Cation Transporter, hOCT1

  Dallas Bednarczyk, Sean Ekins, James H. Wikel and Stephen H. Wright

  Molecular Pharmacology March 2003, 63 (3) 489-498; DOI: https://doi.org/10.1124/mol.63.3.489
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  Molecular Modeling of Interactions of Dihydropyridines and Phenylalkylamines with the Inner Pore of the L-Type Ca²⁺Channel

  Gregory M. Lipkind and Harry A. Fozzard

  Molecular Pharmacology March 2003, 63 (3) 499-511; DOI: https://doi.org/10.1124/mol.63.3.499
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  Potentiation of Lipopolysaccharide-Inducible Cyclooxygenase 2 Expression by C2-Ceramide via c-Jun N-Terminal Kinase-Mediated Activation of CCAAT/Enhancer Binding Protein β in Macrophages

  Yang Hee Cho, Chang Ho Lee and Sang Geon Kim

  Molecular Pharmacology March 2003, 63 (3) 512-523; DOI: https://doi.org/10.1124/mol.63.3.512
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  Molecular Mechanism of Nuclear Translocation of an Orphan Nuclear Receptor, SXR

  Katsuyoshi Kawana, Togo Ikuta, Yasuhito Kobayashi, Osamu Gotoh, Ken Takeda and Kaname Kawajiri

  Molecular Pharmacology March 2003, 63 (3) 524-531; DOI: https://doi.org/10.1124/mol.63.3.524
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  In Vitro Study of the Functional Expression of Organic Anion Transporting Polypeptide 3 at Rat Choroid Plexus Epithelial Cells and Its Involvement in the Cerebrospinal Fluid-to-Blood Transport of Estrone-3-Sulfate

  Sumio Ohtsuki, Takuya Takizawa, Hitomi Takanaga, Nobuyuki Terasaki, Takeo Kitazawa, Masako Sasaki, Takaaki Abe, Ken-ichi Hosoya and Tetsuya Terasaki

  Molecular Pharmacology March 2003, 63 (3) 532-537; DOI: https://doi.org/10.1124/mol.63.3.532
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  Structural Analysis of the Activation of Ribavirin Analogs by NDP Kinase: Comparison with Other Ribavirin Targets

  Sarah Gallois-Montbrun, Yuxing Chen, Hélène Dutartre, Magali Sophys, Solange Morera, Catherine Guerreiro, Benoit Schneider, Laurence Mulard, Joël Janin, Michel Veron, Dominique Deville-Bonne and Bruno Canard

  Molecular Pharmacology March 2003, 63 (3) 538-546; DOI: https://doi.org/10.1124/mol.63.3.538
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  Molecular Site of Action of the Antiarrhythmic Drug Propafenone at the Voltage-Operated Potassium Channel Kv2.1

  Michael Madeja, Thorsten Leicher, Patrick Friederich, Mark A. Punke, Wilhelm Haverkamp, Ulrich Mußhoff, Günter Breithardt and Erwin-Josef Speckmann

  Molecular Pharmacology March 2003, 63 (3) 547-556; DOI: https://doi.org/10.1124/mol.63.3.547
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  Differential Regulation of Nonsteroidal Anti-Inflammatory Drug-Activated Gene in Normal Human Tracheobronchial Epithelial and Lung Carcinoma Cells by Retinoids

  Donna Newman, Morito Sakaue, Ja Seok Koo, Kyung-Su Kim, Seung Joon Baek, Thomas Eling and Anton M. Jetten

  Molecular Pharmacology March 2003, 63 (3) 557-564; DOI: https://doi.org/10.1124/mol.63.3.557
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  N-(4-Hydroxyphenyl)retinamide Inhibits Retinoblastoma Growth through Reactive Oxygen Species-Mediated Cell Death

  Francesca Tosetti, Roberta Venè, Giuseppe Arena, Monica Morini, Simona Minghelli, Douglas M. Noonan and Adriana Albini

  Molecular Pharmacology March 2003, 63 (3) 565-573; DOI: https://doi.org/10.1124/mol.63.3.565
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  Deficiency of Nicotinic Acetylcholine Receptor β4 Subunit Causes Autonomic Cardiac and Intestinal Dysfunction

  Ningshan Wang, Avi Orr-Urtreger, Joab Chapman, Ruth Rabinowitz and Amos D. Korczyn

  Molecular Pharmacology March 2003, 63 (3) 574-580; DOI: https://doi.org/10.1124/mol.63.3.574
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  Differential Effects of Catalase on Apoptosis Induction in Human Promonocytic Cells. Relationships with Heat-Shock Protein Expression

  Patricia Sancho, Alfonso Troyano, Carlos Fernández, Elena De Blas and Patricio Aller

  Molecular Pharmacology March 2003, 63 (3) 581-589; DOI: https://doi.org/10.1124/mol.63.3.581
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  Human Renal Organic Anion Transporter 1-Dependent Uptake and Toxicity of Mercuric-Thiol Conjugates in Madin-Darby Canine Kidney Cells

  Amy G. Aslamkhan, Yong-Hae Han, Xiao-Ping Yang, Rudolfs K. Zalups and John B. Pritchard

  Molecular Pharmacology March 2003, 63 (3) 590-596; DOI: https://doi.org/10.1124/mol.63.3.590
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  Functional Analysis of Murine Aryl Hydrocarbon (AH) Receptors Defective in Nuclear Import: Impact on AH Receptor Degradation and Gene Regulation

  Zhijuan Song and Richard S. Pollenz

  Molecular Pharmacology March 2003, 63 (3) 597-606; DOI: https://doi.org/10.1124/mol.63.3.597
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  Activation of p38 Mitogen-Activated Protein Kinase and Activator Protein-1 during the Promotion of Neurite Extension of PC-12 Cells by 15-Deoxy-Δ^12,14-prostaglandin J₂

  Kyung Mi Jung, Ki Sook Park, Jae Ho Oh, Soo Youn Jung, Ki Hwa Yang, Youn Sook Song, Dong Ju Son, Young Hyun Park, Yeo Pyo Yun, Myung Koo Lee, Ki Wan Oh and Jin Tae Hong

  Molecular Pharmacology March 2003, 63 (3) 607-616; DOI: https://doi.org/10.1124/mol.63.3.607
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  Erythromycin, Roxithromycin, and Clarithromycin: Use of Slow-Binding Kinetics to Compare Their in Vitro Interaction with a Bacterial Ribosomal Complex Active in Peptide Bond Formation

  George P. Dinos, Sean R. Connell, Knud H. Nierhaus and Dimitrios L. Kalpaxis

  Molecular Pharmacology March 2003, 63 (3) 617-623; DOI: https://doi.org/10.1124/mol.63.3.617
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  Small Ligands Modulating the Activity of Mammalian Adenylyl Cyclases: A Novel Mode of Inhibition by Calmidazolium

  Anders Haunsø, James Simpson and Ferenc A. Antoni

  Molecular Pharmacology March 2003, 63 (3) 624-631; DOI: https://doi.org/10.1124/mol.63.3.624
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  Telomere Dysfunction Increases Cisplatin and Ecteinascidin-743 Sensitivity of Melanoma Cells

  Annamaria Biroccio, Chiara Gabellini, Sarah Amodei, Barbara Benassi, Donatella Del Bufalo, Raffaella Elli, Anna Antonelli, Maurizio D'Incalci and Gabriella Zupi

  Molecular Pharmacology March 2003, 63 (3) 632-638; DOI: https://doi.org/10.1124/mol.63.3.632
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  Purinergic P2Y₁₂ Receptor Blockade Inhibits Shear-Induced Platelet Phosphatidylinositol 3-Kinase Activation

  Julio C. Reséndiz, Shuju Feng, Guilan Ji, Ketia A. Francis, Michael C. Berndt and Michael H. Kroll

  Molecular Pharmacology March 2003, 63 (3) 639-645; DOI: https://doi.org/10.1124/mol.63.3.639
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  Ruthenium Red Inhibits TASK-3 Potassium Channel by Interconnecting Glutamate 70 of the Two Subunits

  Gábor Czirják and Péter Enyedi

  Molecular Pharmacology March 2003, 63 (3) 646-652; DOI: https://doi.org/10.1124/mol.63.3.646
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  Cocaine Affinity Decreased by Mutations of Aromatic Residue Phenylalanine 105 in the Transmembrane Domain 2 of Dopamine Transporter

  Xiaohong Wu and Howard H. Gu

  Molecular Pharmacology March 2003, 63 (3) 653-658; DOI: https://doi.org/10.1124/mol.63.3.653
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  Different Ability of Clenbuterol and Salbutamol to Block Sodium Channels Predicts Their Therapeutic Use in Muscle Excitability Disorders

  Jean-François Desaphy, Sabata Pierno, Annamaria De Luca, Paola Didonna and Diana Conte Camerino

  Molecular Pharmacology March 2003, 63 (3) 659-670; DOI: https://doi.org/10.1124/mol.63.3.659
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  Selective Inhibitors of Cyclooxygenase-2 Delay the Activation of Nuclear Factor κB and Attenuate the Expression of Inflammatory Genes in Murine Macrophages Treated with Lipopolysaccharide

  Nuria A. Callejas, Amalia Fernández-Martı́nez, Antonio Castrillo, Lisardo Boscá and Paloma Martı́n-Sanz

  Molecular Pharmacology March 2003, 63 (3) 671-677; DOI: https://doi.org/10.1124/mol.63.3.671
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  Increased Antiviral Activity of 1-O-Hexadecyloxypropyl-[2-¹⁴C]cidofovir in MRC-5 Human Lung Fibroblasts Is Explained by Unique Cellular Uptake and Metabolism

  Kathy A. Aldern, Stephanie L. Ciesla, Kristine L. Winegarden and Karl Y. Hostetler

  Molecular Pharmacology March 2003, 63 (3) 678-681; DOI: https://doi.org/10.1124/mol.63.3.678
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  Pharmacological Interference with Dimerization of Human Neuronal Nitric-Oxide Synthase Expressed in Adenovirus-Infected DLD-1 Cells

  Hans-Jörg Habisch, Antonius C. F. Gorren, Haiying Liang, Richard C. Venema, John F. Parkinson, Kurt Schmidt and Bernd Mayer

  Molecular Pharmacology March 2003, 63 (3) 682-689; DOI: https://doi.org/10.1124/mol.63.3.682
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  Cyclic AMP Inhibition of Tumor Necrosis Factor α Production Induced by Amyloidogenic C-Terminal Peptide of Alzheimer's Amyloid Precursor Protein in Macrophages: Involvement of Multiple Intracellular Pathways and Cyclic AMP Response Element Binding Protein

  Young Hae Chong, Yoo Jung Shin and Yoo-Hun Suh

  Molecular Pharmacology March 2003, 63 (3) 690-698; DOI: https://doi.org/10.1124/mol.63.3.690
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  Selective Ligands and Cellular Effectors of a G Protein-Coupled Endothelial Cannabinoid Receptor

  László Offertáler, Fong-Ming Mo, Sándor Bátkai, Jie Liu, Malcolm Begg, Raj K. Razdan, Billy R. Martin, Richard D. Bukoski and George Kunos

  Molecular Pharmacology March 2003, 63 (3) 699-705; DOI: https://doi.org/10.1124/mol.63.3.699
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  Poly(ADP-ribose) Polymerase Activation and Changes in Bax Protein Expression Associated with Extracellular ATP-Mediated Apoptosis in Human Embryonic Kidney 293-P2X₇ Cells

  Long T. Wen, Charles C. Caldwell and Aileen F. Knowles

  Molecular Pharmacology March 2003, 63 (3) 706-713; DOI: https://doi.org/10.1124/mol.63.3.706
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  Tumor Necrosis Factor-α–Induced Activation of RhoA in Airway Smooth Muscle Cells: Role in the Ca²⁺ Sensitization of Myosin Light Chain₂₀ Phosphorylation

  Irene Hunter, Hannah J. Cobban, Peter Vandenabeele, David J. MacEwan and Graeme F. Nixon

  Molecular Pharmacology March 2003, 63 (3) 714-721; DOI: https://doi.org/10.1124/mol.63.3.714
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  Dehydroepiandrosterone Affects the Expression of Multiple Genes in Rat Liver Including 11β-Hydroxysteroid Dehydrogenase Type 1: A cDNA Array Analysis

  Shi Gu, Sharon L. Ripp, Russell A. Prough and Thomas E. Geoghegan

  Molecular Pharmacology March 2003, 63 (3) 722-731; DOI: https://doi.org/10.1124/mol.63.3.722
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  Hypersensitivity Reactions to Carbamazepine: Characterization of the Specificity, Phenotype, and Cytokine Profile of Drug-Specific T Cell Clones

  D. J. Naisbitt, M. Britschgi, G. Wong, J. Farrell, J. P. H. Depta, D. W. Chadwick, W. J. Pichler, M. Pirmohamed and B. K. Park

  Molecular Pharmacology March 2003, 63 (3) 732-741; DOI: https://doi.org/10.1124/mol.63.3.732
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  Usefulness of Liposomes Loaded with Cytostatic Bile Acid Derivatives to Circumvent Chemotherapy Resistance of Enterohepatic Tumors

  Oscar Briz, Rocio I. R. Macias, Marta Vallejo, Augusto Silva, Maria Angeles Serrano and Jose J. G. Marin

  Molecular Pharmacology March 2003, 63 (3) 742-750; DOI: https://doi.org/10.1124/mol.63.3.742
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  Mechanism of Corticotropin-Releasing Factor Type I Receptor Regulation by Nonpeptide Antagonists

  Sam R. J. Hoare, Sue K. Sullivan, Nicholas Ling, Paul D. Crowe and Dimitri E. Grigoriadis

  Molecular Pharmacology March 2003, 63 (3) 751-765; DOI: https://doi.org/10.1124/mol.63.3.751
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  Genotoxic Profiling of MCF-7 Breast Cancer Cell Line Elucidates Gene Expression Modifications Underlying Toxicity of the Anticancer Drug 2-(4-Amino-3-methylphenyl)-5-fluorobenzothiazole

  Anne Monks, Erik Harris, Curtis Hose, John Connelly and Edward A. Sausville

  Molecular Pharmacology March 2003, 63 (3) 766-772; DOI: https://doi.org/10.1124/mol.63.3.766