Molecular Pharmacology: 63 (4)

April 01, 2003; Volume 63,Issue 4

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Knock-Out Mice Reveal Tissue-Specific Roles of P2Y Receptor Subtypes in Different Epithelia
George R. Dubyak

Molecular Pharmacology April 2003, 63 (4) 773-776; DOI: https://doi.org/10.1124/mol.63.4.773

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Loss of Nucleotide Regulation of Epithelial Chloride Transport in the Jejunum of P2Y₄-Null Mice
Bernard Robaye, Esam Ghanem, Françoise Wilkin, Dominique Fokan, Willy Van Driessche, Stéphane Schurmans, Jean-Marie Boeynaems and Renaud Beauwens

Molecular Pharmacology April 2003, 63 (4) 777-783; DOI: https://doi.org/10.1124/mol.63.4.777

Articles

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Nuclear Translocation of Nuclear Transcription Factor-κB by α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Receptors Leads to Transcription of p53 and Cell Death in Dopaminergic Neurons
Gabriel A. de Erausquin, Krzyztof Hyrc, David A. Dorsey, Daniel Mamah, Mehmet Dokucu, Daniel H. Mascó, Timothy Walton, Krikor Dikranian, Mario Soriano, José Manuel Garcı́a Verdugo, Mark P. Goldberg and Laura L. Dugan

Molecular Pharmacology April 2003, 63 (4) 784-790; DOI: https://doi.org/10.1124/mol.63.4.784
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Mutation of the Androgen Receptor at Amino Acid 708 (Gly→Ala) Abolishes Partial Agonist Activity of Steroidal Antiandrogens
Béatrice Terouanne, Philippe Nirdé, Fanja Rabenoelina, William Bourguet, Charles Sultan and Gilles Auzou

Molecular Pharmacology April 2003, 63 (4) 791-798; DOI: https://doi.org/10.1124/mol.63.4.791
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Brominated Derivatives of Noscapine Are Potent Microtubule-interfering Agents That Perturb Mitosis and Inhibit Cell Proliferation
Jun Zhou, Kamlesh Gupta, Shefali Aggarwal, Ritu Aneja, Ramesh Chandra, Dulal Panda and Harish C. Joshi

Molecular Pharmacology April 2003, 63 (4) 799-807; DOI: https://doi.org/10.1124/mol.63.4.799
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Involvements of Voltage-Independent Ca²⁺ Channels and Phosphoinositide 3-Kinase in Endothelin-1–Induced PYK2 Tyrosine Phosphorylation
Yoshifumi Kawanabe, Nobuo Hashimoto and Tomoh Masaki

Molecular Pharmacology April 2003, 63 (4) 808-813; DOI: https://doi.org/10.1124/mol.63.4.808
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A Leishmania major Nucleobase Transporter Responsible for Allopurinol Uptake Is a Functional Homolog of theTrypanosoma brucei H2 Transporter.
Mohammed I. Al-Salabi, Lynsey J. M. Wallace and Harry P. de Koning

Molecular Pharmacology April 2003, 63 (4) 814-820; DOI: https://doi.org/10.1124/mol.63.4.814
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Unexpected Induction of the Human Connexin 43 Promoter by the Ras Signaling Pathway Is Mediated by a Novel Putative Promoter Sequence
George D. Carystinos, Mustapha Kandouz, Moulay A. Alaoui-Jamali and Gerald Batist

Molecular Pharmacology April 2003, 63 (4) 821-831; DOI: https://doi.org/10.1124/mol.63.4.821
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Mechanism of Action of G_q to Inhibit Gβγ Modulation of Ca_V2.2 Calcium Channels: Probed by the Use of Receptor-Gα Tandems
Federica Bertaso, Richard J. Ward, Patricia Viard, Graeme Milligan and Annette C. Dolphin

Molecular Pharmacology April 2003, 63 (4) 832-843; DOI: https://doi.org/10.1124/mol.63.4.832
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Involvement of Organic Cation Transporter 1 in the Lactic Acidosis Caused by Metformin
De-Sheng Wang, Hiroyuki Kusuhara, Yukio Kato, Johan W. Jonker, Alfred H. Schinkel and Yuichi Sugiyama

Molecular Pharmacology April 2003, 63 (4) 844-848; DOI: https://doi.org/10.1124/mol.63.4.844
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Anthracyclines Induce Accumulation of Iron in Ferritin in Myocardial and Neoplastic Cells: Inhibition of the Ferritin Iron Mobilization Pathway
J. C. Kwok and D. R. Richardson

Molecular Pharmacology April 2003, 63 (4) 849-861; DOI: https://doi.org/10.1124/mol.63.4.849
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Gemcitabine Potentiates Cisplatin Cytotoxicity and Inhibits Repair of Cisplatin-DNA Damage in Ovarian Cancer Cell Lines
Mazin A. Moufarij, Don R. Phillips and Carleen Cullinane

Molecular Pharmacology April 2003, 63 (4) 862-869; DOI: https://doi.org/10.1124/mol.63.4.862
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Characterization of Celecoxib and Valdecoxib Binding to Cyclooxygenase
William F. Hood, James K. Gierse, Peter C. Isakson, James R. Kiefer, Ravi G. Kurumbail, Karen Seibert and Joseph B. Monahan

Molecular Pharmacology April 2003, 63 (4) 870-877; DOI: https://doi.org/10.1124/mol.63.4.870
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P2Y Receptors Modulate Ion Channel Function through Interactions Involving The C-Terminal Domain
So Yeong Lee, Samuel C. Wolff, Robert A. Nicholas and Scott M. O'Grady

Molecular Pharmacology April 2003, 63 (4) 878-885; DOI: https://doi.org/10.1124/mol.63.4.878
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Activation of Endothelial Nitric-Oxide Synthase by Tumor Necrosis Factor-α: A Novel Pathway Involving Sequential Activation of Neutral Sphingomyelinase, Phosphatidylinositol-3′ kinase, and Akt
Rico Barsacchi, Cristiana Perrotta, Stefania Bulotta, Salvador Moncada, Nica Borgese and Emilio Clementi

Molecular Pharmacology April 2003, 63 (4) 886-895; DOI: https://doi.org/10.1124/mol.63.4.886
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γ-Hydroxybutyric Acid and Diazepam Antagonize a Rapid Increase in GABA_A Receptors α₄ Subunit mRNA Abundance Induced by Ethanol Withdrawal in Cerebellar Granule Cells
Paolo Follesa, Luisa Mancuso, Francesca Biggio, Maria Cristina Mostallino, Annalisa Manca, Maria Paola Mascia, Fabio Busonero, Giuseppe Talani, Enrico Sanna and Giovanni Biggio

Molecular Pharmacology April 2003, 63 (4) 896-907; DOI: https://doi.org/10.1124/mol.63.4.896
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The Cannabinoid CB₁ Receptor Antagonist SR141716 Increases Acrp30 mRNA Expression in Adipose Tissue of Obese fa/fa Rats and in Cultured Adipocyte Cells
M. Bensaid, M. Gary-Bobo, A. Esclangon, J. P. Maffrand, G. Le Fur, F. Oury-Donat and P. Soubrié

Molecular Pharmacology April 2003, 63 (4) 908-914; DOI: https://doi.org/10.1124/mol.63.4.908
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Species-Specific Transcriptional Activity of Synthetic Flavonoids in Guinea Pig and Mouse Cells as a Result of Differential Activation of the Aryl Hydrocarbon Receptor to Interact with Dioxin-Responsive Elements
Jun-guo Zhou, Ellen C. Henry, Christine M. Palermo, Stephen D. Dertinger and Thomas A. Gasiewicz

Molecular Pharmacology April 2003, 63 (4) 915-924; DOI: https://doi.org/10.1124/mol.63.4.915
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Resveratrol Increases Serine¹⁵-Phosphorylated but Transcriptionally Impaired p53 and Induces a Reversible DNA Replication Block in Serum-Activated Vascular Smooth Muscle Cells
Ursula G. B. Haider, Dan Sorescu, Kathy K. Griendling, Angelika M. Vollmar and Verena M. Dirsch

Molecular Pharmacology April 2003, 63 (4) 925-932; DOI: https://doi.org/10.1124/mol.63.4.925
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Antitumor and Cellular Pharmacological Properties of a Novel Platinum(IV) Complex:trans-[PtCl₂(OH)₂(Dimethylamine) (Isopropylamine)]
José M. Pérez, Lloyd R. Kelland, Eva I. Montero, Frances E. Boxall, Miguel A. Fuertes, Carlos Alonso and Carmen Navarro-Ranninger

Molecular Pharmacology April 2003, 63 (4) 933-944; DOI: https://doi.org/10.1124/mol.63.4.933
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Opposite Regulation of the Human Paraoxonase-1 Gene PON-1 by Fenofibrate and Statins
Cédric Gouédard, Nadine Koum-Besson, Robert Barouki and Yannick Morel

Molecular Pharmacology April 2003, 63 (4) 945-956; DOI: https://doi.org/10.1124/mol.63.4.945

Errata

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Correction to “The copper transporter CTR1 regulates cisplatin uptake in Saccharomyces cerevisiae”
Molecular Pharmacology April 2003, 63 (4) 957; DOI: https://doi.org/10.1124/mol.63.4.957
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Correction to “High affinity antagonists of the vanilloid receptor”
Molecular Pharmacology April 2003, 63 (4) 958; DOI: https://doi.org/10.1124/mol.63.4.958

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