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Research ArticleArticle

[3H]R214127: A Novel High-Affinity Radioligand for the mGlu1 Receptor Reveals a Common Binding Site Shared by Multiple Allosteric Antagonists

Hilde Lavreysen, Cor Janssen, François Bischoff, Xavier Langlois, Josée E. Leysen and Anne S. J. Lesage
Molecular Pharmacology May 2003, 63 (5) 1082-1093; DOI: https://doi.org/10.1124/mol.63.5.1082

Article Information

vol. 63 no. 5 1082-1093
DOI 
https://doi.org/10.1124/mol.63.5.1082
PubMed 
12695537
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received October 21, 2002
  • Accepted February 4, 2003
  • Published online May 1, 2003.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Hilde Lavreysen1,4,
  2. Cor Janssen2,
  3. François Bischoff3,
  4. Xavier Langlois1,
  5. Josée E. Leysen4 and
  6. Anne S. J. Lesage1
  1. 1CNS Discovery Research (H.L., X.L., A.S.J.L.) and Departments of 2Preclinical Pharmacokinetics (C.J.) and 3Medicinal Chemistry (F.B.), Johnson and Johnson Pharmaceutical Research and Development, Beerse, Belgium; 4Free University of Amsterdam, Amsterdam, The Netherlands (H.L., J.E.L.)
  1. Anne S. J. Lesage. CNS Discovery Research, Johnson and Johnson Pharmaceutical Research and Development, Turnhoutseweg 30 B-2340 Beerse, Belgium. E-mail:alesage{at}prdbe.jnj.com
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[3H]R214127: A Novel High-Affinity Radioligand for the mGlu1 Receptor Reveals a Common Binding Site Shared by Multiple Allosteric Antagonists

Hilde Lavreysen, Cor Janssen, François Bischoff, Xavier Langlois, Josée E. Leysen and Anne S. J. Lesage
Molecular Pharmacology May 1, 2003, 63 (5) 1082-1093; DOI: https://doi.org/10.1124/mol.63.5.1082
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