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Research ArticleArticle

Identification of Tyrosine 189 and Asparagine 358 of the Cholecystokinin 2 Receptor in Direct Interaction with the Crucial C-Terminal Amide of Cholecystokinin by Molecular Modeling, Site-Directed Mutagenesis, and Structure/Affinity Studies

Céline Galés, Marc Poirot, Julien Taillefer, Bernard Maigret, Jean Martinez, Luis Moroder, Chantal Escrieut, Lucien Pradayrol, Daniel Fourmy and Sandrine Silvente-Poirot
Molecular Pharmacology May 2003, 63 (5) 973-982; DOI: https://doi.org/10.1124/mol.63.5.973

Article Information

vol. 63 no. 5 973-982
DOI 
https://doi.org/10.1124/mol.63.5.973
PubMed 
12695525
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received July 22, 2002
  • Accepted January 17, 2003
  • Published online May 1, 2003.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Céline Galés1,
  2. Marc Poirot2,
  3. Julien Taillefer1,
  4. Bernard Maigret3,
  5. Jean Martinez4,
  6. Luis Moroder5,
  7. Chantal Escrieut1,
  8. Lucien Pradayrol1,
  9. Daniel Fourmy1 and
  10. Sandrine Silvente-Poirot
  1. 1Institut National de la Santé et de la Recherche Médicale (INSERM) U 531, Institut Louis Bugnard, CHU Rangueil, Toulouse, France (C.G., J.T., C.E., L.P., D.F.); 2INSERM U 563, Département Innovation Thérapeutique et Oncologie Moléculaire, Institut Claudius Regaud, Toulouse, France (M.P.); 3Laboratoire de Chimie Théorique, Université de Nancy, Vandoeuvre, Nancy, France (B.M.); 4Centre National de la Recherche Scientifique–Unité de Recherche Associée 1845, Faculté de Pharmacie, Montpellier, France (J.M.); and 5Max Planck Institute für Biochemie, Martinsried, Germany (L.M.).
  1. Sandrine Silvente-Poirot, INSERM U563, Département Innovation Thérapeutique et Oncologie Moléculaire, Institut Claudius Regaud, 20-24 rue du Pont Saint Pierre, 31052 Toulouse Cedex, France. Email:poirot_s{at}icr.fnclcc.fr
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Research ArticleArticle

Identification of Tyrosine 189 and Asparagine 358 of the Cholecystokinin 2 Receptor in Direct Interaction with the Crucial C-Terminal Amide of Cholecystokinin by Molecular Modeling, Site-Directed Mutagenesis, and Structure/Affinity Studies

Céline Galés, Marc Poirot, Julien Taillefer, Bernard Maigret, Jean Martinez, Luis Moroder, Chantal Escrieut, Lucien Pradayrol, Daniel Fourmy and Sandrine Silvente-Poirot
Molecular Pharmacology May 1, 2003, 63 (5) 973-982; DOI: https://doi.org/10.1124/mol.63.5.973
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