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Molecular Pharmacology

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Table of Contents

June 01, 2003; Volume 63,Issue 6

Perspectives

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    Acid Tests of N-Methyl-d-aspartate Receptor Gating Basics
    Jon W. Johnson
    Molecular Pharmacology June 2003, 63 (6) 1199-1201; DOI: https://doi.org/10.1124/mol.63.6.1199
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    The Evolutionarily Triumphant G-Protein-Coupled Receptor
    Dianne M. Perez
    Molecular Pharmacology June 2003, 63 (6) 1202-1205; DOI: https://doi.org/10.1124/mol.63.6.1202
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    Nitric Oxide Signaling in Brain: Potentiating the Gain with YC-1
    David S. Bredt
    Molecular Pharmacology June 2003, 63 (6) 1206-1208; DOI: https://doi.org/10.1124/mol.63.6.1206
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    Cyclic Nucleotide Phosphodiesterase 5 and Sildenafil: Promises Realized
    Vincent Manganiello
    Molecular Pharmacology June 2003, 63 (6) 1209-1211; DOI: https://doi.org/10.1124/mol.63.6.1209

Accelerated Communications

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    Molecular Determinants of Proton-Sensitive N-Methyl-d-aspartate Receptor Gating
    Chian-Ming Low, Polina Lyuboslavsky, Adam French, Phuong Le, Karen Wyatte, William H. Thiel, Edward M. Marchan, Kazuei Igarashi, Keiko Kashiwagi, Kim Gernert, Keith Williams, Stephen F. Traynelis and Fang Zheng
    Molecular Pharmacology June 2003, 63 (6) 1212-1222; DOI: https://doi.org/10.1124/mol.63.6.1212
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    3,4-Methylenedioxymethamphetamine (MDMA, “Ecstasy”) Induces Fenfluramine-Like Proliferative Actions on Human Cardiac Valvular Interstitial Cells in Vitro
    Vincent Setola, Sandra J. Hufeisen, K. Jane Grande-Allen, Ivan Vesely, Richard A. Glennon, Bruce Blough, Richard B. Rothman and Bryan L. Roth
    Molecular Pharmacology June 2003, 63 (6) 1223-1229; DOI: https://doi.org/10.1124/mol.63.6.1223

Articles

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    Structural Evaluation of the Agonistic Action of a Vitamin D Analog with Two Side Chains Binding to the Nuclear Vitamin D Receptor
    Sami Väisänen, Mikael Peräkylä, Jouni I. Kärkkäinen, Milan R. Uskokovic and Carsten Carlberg
    Molecular Pharmacology June 2003, 63 (6) 1230-1237; DOI: https://doi.org/10.1124/mol.63.6.1230
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    Hypertonicity Inhibits Lipopolysaccharide-Induced Nitric Oxide Synthase Expression in Smooth Muscle Cells by Inhibiting Nuclear Factor κB
    Sandeep C. Pingle, Joseph F. Sanchez, Daniel M. Hallam, Andrea L. Williamson, Sanjay B. Maggirwar and Vickram Ramkumar
    Molecular Pharmacology June 2003, 63 (6) 1238-1247; DOI: https://doi.org/10.1124/mol.63.6.1238
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    Non-Nuclear Localized Human NOSII Enhances the Bioactivation and Toxicity of Tirapazamine (SR4233) in Vitro
    Edwin C. Chinje, Rachel L. Cowen, Jian Feng, Sanjeev P. Sharma, Natasha S. Wind, Adrian L. Harris and Ian J. Stratford
    Molecular Pharmacology June 2003, 63 (6) 1248-1255; DOI: https://doi.org/10.1124/mol.63.6.1248
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    The G-Protein-Coupled Receptors in the Human Genome Form Five Main Families. Phylogenetic Analysis, Paralogon Groups, and Fingerprints
    Robert Fredriksson, Malin C. Lagerström, Lars-Gustav Lundin and Helgi B. Schiöth
    Molecular Pharmacology June 2003, 63 (6) 1256-1272; DOI: https://doi.org/10.1124/mol.63.6.1256
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    Diazonamide A and a Synthetic Structural Analog: Disruptive Effects on Mitosis and Cellular Microtubules and Analysis of Their Interactions with Tubulin
    Zobeida Cruz-Monserrate, Hélène C. Vervoort, Ruoli Bai, David J. Newman, Stephen B. Howell, Gerrit Los, Jeffrey T. Mullaney, Michael D. Williams, George R. Pettit, William Fenical and Ernest Hamel
    Molecular Pharmacology June 2003, 63 (6) 1273-1280; DOI: https://doi.org/10.1124/mol.63.6.1273
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    Decrease in Survival Threshold of Quiescent Colon Carcinoma Cells in the Presence of a Small Molecule Integrin Antagonist
    Mike F. Burbridge, Virginie Venot, Patrick J. Casara, Françoise Perron-Sierra, John A. Hickman and Gordon C. Tucker
    Molecular Pharmacology June 2003, 63 (6) 1281-1288; DOI: https://doi.org/10.1124/mol.63.6.1281
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    Inhibition of Human Insulin Gene Transcription by the Immunosuppressive Drugs Cyclosporin A and Tacrolimus in Primary, Mature Islets of Transgenic Mice
    Elke Oetjen, Diana Baun, Stephan Beimesche, Doris Krause, Irmgard Cierny, Roland Blume, Corinna Dickel, Simone Wehner and Willhart Knepel
    Molecular Pharmacology June 2003, 63 (6) 1289-1295; DOI: https://doi.org/10.1124/mol.63.6.1289
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    Thyroid Hormone Induction of the Adrenoleukodystrophy-Related Gene (ABCD2)
    Stéphane Fourcade, Stéphane Savary, Catherine Gondcaille, Johannes Berger, Angela Netik, Françoise Cadepond, Martine El Etr, Brunhilde Molzer and Maurice Bugaut
    Molecular Pharmacology June 2003, 63 (6) 1296-1303; DOI: https://doi.org/10.1124/mol.63.6.1296
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    2-Aminoethoxydiphenyl Borane Activates a Novel Calcium-Permeable Cation Channel
    Franz-Josef Braun, Omar Aziz and James W. Putney
    Molecular Pharmacology June 2003, 63 (6) 1304-1311; DOI: https://doi.org/10.1124/mol.63.6.1304
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    Agonist Actions of “β-Blockers” Provide Evidence for Two Agonist Activation Sites or Conformations of the Human β1-Adrenoceptor
    Jillian G. Baker, Ian P. Hall and Stephen J. Hill
    Molecular Pharmacology June 2003, 63 (6) 1312-1321; DOI: https://doi.org/10.1124/mol.63.6.1312
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    Enhancement of Long-Term Potentiation by a Potent Nitric Oxide-Guanylyl Cyclase Activator, 3-(5-Hydroxymethyl-2-furyl)-1-benzyl-indazole
    Wei-Lin Chien, Keng-Chen Liang, Che-Ming Teng, Sheng-Chu Kuo, Fang-Yu Lee and Wen-Mei Fu
    Molecular Pharmacology June 2003, 63 (6) 1322-1328; DOI: https://doi.org/10.1124/mol.63.6.1322
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    Developmental Expression of Heteromeric Nicotinic Receptor Subtypes in Chick Retina
    S. Vailati, M. Moretti, R. Longhi, G. E. Rovati, F. Clementi and C. Gotti
    Molecular Pharmacology June 2003, 63 (6) 1329-1337; DOI: https://doi.org/10.1124/mol.63.6.1329
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    Developmental Changes in β2-Adrenergic Receptor Signaling in Ventricular Myocytes: the Role of Gi proteins and Caveolae Microdomains
    Vitalyi O. Rybin, Elena Pak, Sasha Alcott and Susan F. Steinberg
    Molecular Pharmacology June 2003, 63 (6) 1338-1348; DOI: https://doi.org/10.1124/mol.63.6.1338
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    Thiol-Modifying Phenylarsine Oxide Inhibits Guanine Nucleotide Binding of Rho but Not of Rac GTPases
    Ralf Gerhard, Harald John, Klaus Aktories and Ingo Just
    Molecular Pharmacology June 2003, 63 (6) 1349-1355; DOI: https://doi.org/10.1124/mol.63.6.1349
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    Characterization of a Ca2+ Response to Both UTP and ATP at Human P2Y11 Receptors: Evidence for Agonist-Specific Signaling
    Pamela J. White, Tania E. Webb and Michael R. Boarder
    Molecular Pharmacology June 2003, 63 (6) 1356-1363; DOI: https://doi.org/10.1124/mol.63.6.1356
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    [3H]Sildenafil Binding to Phosphodiesterase-5 Is Specific, Kinetically Heterogeneous, and Stimulated by cGMP
    Jackie D. Corbin, Mitsi A. Blount, James L. Weeks, Alfreda Beasley, Karl P. Kuhn, Yew S. J. Ho, Layla F. Saidi, James H. Hurley, Jun Kotera and Sharron H. Francis
    Molecular Pharmacology June 2003, 63 (6) 1364-1372; DOI: https://doi.org/10.1124/mol.63.6.1364
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    Aryl Hydrocarbon Receptor Gene Silencing with Small Inhibitory RNA Differentially Modulates Ah-Responsiveness in MCF-7 and HepG2 Cancer Cells
    Maen Abdelrahim, Roger Smith and Stephen Safe
    Molecular Pharmacology June 2003, 63 (6) 1373-1381; DOI: https://doi.org/10.1124/mol.63.6.1373
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    DNA Sequence Specificity for Topoisomerase II Poisoning by the Quinoxaline Anticancer Drugs XK469 and CQS
    Hanlin Gao, Edith F. Yamasaki, Kenneth K. Chan, Linus L. Shen and Robert M. Snapka
    Molecular Pharmacology June 2003, 63 (6) 1382-1388; DOI: https://doi.org/10.1124/mol.63.6.1382
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    Closure of Gap Junction Channels by Arylaminobenzoates
    Miduturu Srinivas and David C. Spray
    Molecular Pharmacology June 2003, 63 (6) 1389-1397; DOI: https://doi.org/10.1124/mol.63.6.1389
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    Point Mutations at L1280 in Nav1.4 Channel D3-S6 Modulate Binding Affinity and Stereoselectivity of Bupivacaine Enantiomers
    Carla Nau, Sho-Ya Wang and Ging Kuo Wang
    Molecular Pharmacology June 2003, 63 (6) 1398-1406; DOI: https://doi.org/10.1124/mol.63.6.1398
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    Pharmacological and Biophysical Properties of the Human P2X5 Receptor
    Xuenong Bo, Lin-Hua Jiang, Heather L. Wilson, Miran Kim, Geoffrey Burnstock, Annmarie Surprenant and R. Alan North
    Molecular Pharmacology June 2003, 63 (6) 1407-1416; DOI: https://doi.org/10.1124/mol.63.6.1407
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    Local Anesthetic Block of Kv Channels: Role of the S6 Helix and the S5-S6 Linker for Bupivacaine Action
    Johanna Nilsson, Michael Madeja and Peter Århem
    Molecular Pharmacology June 2003, 63 (6) 1417-1429; DOI: https://doi.org/10.1124/mol.63.6.1417
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    Extra- and Intracellular Sphingosylphosphorylcholine Promote Spontaneous Transmitter Release from Frog Motor Nerve Endings
    Eugen Brailoiu and Nae J. Dun
    Molecular Pharmacology June 2003, 63 (6) 1430-1436; DOI: https://doi.org/10.1124/mol.63.6.1430
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    A Key Role for Caspase-2 and Caspase-3 in the Apoptosis Induced by 2-Chloro-2′-deoxy-adenosine (Cladribine) and 2-Chloro-adenosine in Human Astrocytoma Cells
    Stefania Ceruti, Elena Beltrami, Paola Matarrese, Alessia Mazzola, Flaminio Cattabeni, Walter Malorni and Maria P. Abbracchio
    Molecular Pharmacology June 2003, 63 (6) 1437-1447; DOI: https://doi.org/10.1124/mol.63.6.1437
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Molecular Pharmacology: 63 (6)
Molecular Pharmacology
Vol. 63, Issue 6
1 Jun 2003
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  • SB-431542 Is a Potent and Specific Inhibitor of Transforming Growth Factor-β Superfamily Type I Activin Receptor-Like Kinase (ALK) Receptors ALK4, ALK5, and ALK7
  • The G-Protein-Coupled Receptors in the Human Genome Form Five Main Families. Phylogenetic Analysis, Paralogon Groups, and Fingerprints
  • Pharmacological Properties of Y-27632, a Specific Inhibitor of Rho-Associated Kinases
  • Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines.
  • The Orphan Human Pregnane X Receptor Mediates the Transcriptional Activation of CYP3A4 by Rifampicin through a Distal Enhancer Module
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