Research ArticleArticle
[3H]Sildenafil Binding to Phosphodiesterase-5 Is Specific, Kinetically Heterogeneous, and Stimulated by cGMP
Jackie D. Corbin, Mitsi A. Blount, James L. Weeks II, Alfreda Beasley, Karl P. Kuhn, Yew S. J. Ho, Layla F. Saidi, James H. Hurley, Jun Kotera and Sharron H. Francis
Molecular Pharmacology June 2003, 63 (6) 1364-1372; DOI: https://doi.org/10.1124/mol.63.6.1364
Jackie D. Corbin
Department of Molecular Physiology and Biophysics (J.D.C., M.A.B., J.L.W., A.B., J.K., S.H.F.) and Center for Lung Research, Division of Allergy, Pulmonary and Critical Care Medicine (K.P.K.), Vanderbilt University School of Medicine, Nashville, Tennessee; and Laboratory of Molecular Biology, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland (Y.S.J.H., L.F.S., J.H.H.)
Mitsi A. Blount
Department of Molecular Physiology and Biophysics (J.D.C., M.A.B., J.L.W., A.B., J.K., S.H.F.) and Center for Lung Research, Division of Allergy, Pulmonary and Critical Care Medicine (K.P.K.), Vanderbilt University School of Medicine, Nashville, Tennessee; and Laboratory of Molecular Biology, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland (Y.S.J.H., L.F.S., J.H.H.)
James L. Weeks II
Department of Molecular Physiology and Biophysics (J.D.C., M.A.B., J.L.W., A.B., J.K., S.H.F.) and Center for Lung Research, Division of Allergy, Pulmonary and Critical Care Medicine (K.P.K.), Vanderbilt University School of Medicine, Nashville, Tennessee; and Laboratory of Molecular Biology, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland (Y.S.J.H., L.F.S., J.H.H.)
Alfreda Beasley
Department of Molecular Physiology and Biophysics (J.D.C., M.A.B., J.L.W., A.B., J.K., S.H.F.) and Center for Lung Research, Division of Allergy, Pulmonary and Critical Care Medicine (K.P.K.), Vanderbilt University School of Medicine, Nashville, Tennessee; and Laboratory of Molecular Biology, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland (Y.S.J.H., L.F.S., J.H.H.)
Karl P. Kuhn
Department of Molecular Physiology and Biophysics (J.D.C., M.A.B., J.L.W., A.B., J.K., S.H.F.) and Center for Lung Research, Division of Allergy, Pulmonary and Critical Care Medicine (K.P.K.), Vanderbilt University School of Medicine, Nashville, Tennessee; and Laboratory of Molecular Biology, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland (Y.S.J.H., L.F.S., J.H.H.)
Yew S. J. Ho
Department of Molecular Physiology and Biophysics (J.D.C., M.A.B., J.L.W., A.B., J.K., S.H.F.) and Center for Lung Research, Division of Allergy, Pulmonary and Critical Care Medicine (K.P.K.), Vanderbilt University School of Medicine, Nashville, Tennessee; and Laboratory of Molecular Biology, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland (Y.S.J.H., L.F.S., J.H.H.)
Layla F. Saidi
Department of Molecular Physiology and Biophysics (J.D.C., M.A.B., J.L.W., A.B., J.K., S.H.F.) and Center for Lung Research, Division of Allergy, Pulmonary and Critical Care Medicine (K.P.K.), Vanderbilt University School of Medicine, Nashville, Tennessee; and Laboratory of Molecular Biology, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland (Y.S.J.H., L.F.S., J.H.H.)
James H. Hurley
Department of Molecular Physiology and Biophysics (J.D.C., M.A.B., J.L.W., A.B., J.K., S.H.F.) and Center for Lung Research, Division of Allergy, Pulmonary and Critical Care Medicine (K.P.K.), Vanderbilt University School of Medicine, Nashville, Tennessee; and Laboratory of Molecular Biology, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland (Y.S.J.H., L.F.S., J.H.H.)
Jun Kotera
Department of Molecular Physiology and Biophysics (J.D.C., M.A.B., J.L.W., A.B., J.K., S.H.F.) and Center for Lung Research, Division of Allergy, Pulmonary and Critical Care Medicine (K.P.K.), Vanderbilt University School of Medicine, Nashville, Tennessee; and Laboratory of Molecular Biology, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland (Y.S.J.H., L.F.S., J.H.H.)
Sharron H. Francis
Department of Molecular Physiology and Biophysics (J.D.C., M.A.B., J.L.W., A.B., J.K., S.H.F.) and Center for Lung Research, Division of Allergy, Pulmonary and Critical Care Medicine (K.P.K.), Vanderbilt University School of Medicine, Nashville, Tennessee; and Laboratory of Molecular Biology, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland (Y.S.J.H., L.F.S., J.H.H.)
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Research ArticleArticle
[3H]Sildenafil Binding to Phosphodiesterase-5 Is Specific, Kinetically Heterogeneous, and Stimulated by cGMP
Jackie D. Corbin, Mitsi A. Blount, James L. Weeks, Alfreda Beasley, Karl P. Kuhn, Yew S. J. Ho, Layla F. Saidi, James H. Hurley, Jun Kotera and Sharron H. Francis
Molecular Pharmacology June 1, 2003, 63 (6) 1364-1372; DOI: https://doi.org/10.1124/mol.63.6.1364
Research ArticleArticle
[3H]Sildenafil Binding to Phosphodiesterase-5 Is Specific, Kinetically Heterogeneous, and Stimulated by cGMP
Jackie D. Corbin, Mitsi A. Blount, James L. Weeks, Alfreda Beasley, Karl P. Kuhn, Yew S. J. Ho, Layla F. Saidi, James H. Hurley, Jun Kotera and Sharron H. Francis
Molecular Pharmacology June 1, 2003, 63 (6) 1364-1372; DOI: https://doi.org/10.1124/mol.63.6.1364
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