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Research ArticleArticle

Allosteric Site on Muscarinic Acetylcholine Receptors: Identification of Two Amino Acids in the Muscarinic M2 Receptor That Account Entirely for the M2/M5 Subtype Selectivities of Some Structurally Diverse Allosteric Ligands in N-Methylscopolamine-Occupied Receptors

Uta Voigtländer, Kirstin Jöhren, Marion Mohr, Alexandra Raasch, Christian Tränkle, Stefan Buller, John Ellis, Hans-Dieter Höltje and Klaus Mohr
Molecular Pharmacology July 2003, 64 (1) 21-31; DOI: https://doi.org/10.1124/mol.64.1.21

Article Information

vol. 64 no. 1 21-31
DOI 
https://doi.org/10.1124/mol.64.1.21
PubMed 
12815157
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received October 7, 2002
  • Accepted March 21, 2003
  • Published online July 1, 2003.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Uta Voigtländer,
  2. Kirstin Jöhren,
  3. Marion Mohr,
  4. Alexandra Raasch,
  5. Christian Tränkle,
  6. Stefan Buller,
  7. John Ellis,
  8. Hans-Dieter Höltje and
  9. Klaus Mohr
  1. Department of Pharmacology and Toxicology, Institute of Pharmacy, University of Bonn, Bonn, Germany (U.V., M.M., A.R., C.T., S.B., K.M.); Institute of Pharmaceutical Chemistry, University of Düsseldorf, Düsseldorf, Germany (K.J., H.-D. H.); and Departments of Psychiatry and Pharmacology, Penn State College of Medicine, Hershey, Pennsylvania, USA (S.B., J.E.).
  1. Address correspondence to:
    Dr. Klaus Mohr, Department of Pharmacology and Toxicology, Institute of Pharmacy, University of Bonn, 53121 Bonn, Germany. E-mail: k.mohr{at}uni-bonn.de
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Research ArticleArticle

Allosteric Site on Muscarinic Acetylcholine Receptors: Identification of Two Amino Acids in the Muscarinic M2 Receptor That Account Entirely for the M2/M5 Subtype Selectivities of Some Structurally Diverse Allosteric Ligands in N-Methylscopolamine-Occupied Receptors

Uta Voigtländer, Kirstin Jöhren, Marion Mohr, Alexandra Raasch, Christian Tränkle, Stefan Buller, John Ellis, Hans-Dieter Höltje and Klaus Mohr
Molecular Pharmacology July 1, 2003, 64 (1) 21-31; DOI: https://doi.org/10.1124/mol.64.1.21
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