Table of Contents

Articles

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  Painful Inflammation-Induced Increase in μ-Opioid Receptor Binding and G-Protein Coupling in Primary Afferent Neurons

  C. Zöllner, M. A. Shaqura, C. P. Bopaiah, S. Mousa, C. Stein and M. Schäfer

  Molecular Pharmacology August 2003, 64 (2) 202-210; DOI: https://doi.org/10.1124/mol.64.2.202
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  Inhibition of Nuclear Factor κB by Phenolic Antioxidants: Interplay between Antioxidant Signaling and Inflammatory Cytokine Expression

  Qiang Ma, Krista Kinneer, Jianping Ye and Bruce J. Chen

  Molecular Pharmacology August 2003, 64 (2) 211-219; DOI: https://doi.org/10.1124/mol.64.2.211
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  Antifolate Resistance Associated with Loss of MRP1 Expression and Function in Chinese Hamster Ovary Cells with Markedly Impaired Export of Folate and Cholate

  Michal Stark, Lilah Rothem, Gerrit Jansen, George L. Scheffer, I. David Goldman and Yehuda G. Assaraf

  Molecular Pharmacology August 2003, 64 (2) 220-227; DOI: https://doi.org/10.1124/mol.64.2.220
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  Calcium-Dependent Prevention of Neuronal Apoptosis by Lithium Ion: Essential Role of Phosphoinositide 3-Kinase and Phospholipase Cγ

  Hyo Jung Kang, Jai Sung Noh, Yun Soo Bae and Byoung Joo Gwag

  Molecular Pharmacology August 2003, 64 (2) 228-234; DOI: https://doi.org/10.1124/mol.64.2.228
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  Key Roles of Phe¹¹¹² and Ser¹¹¹⁵ in the Pore-Forming IIIS5-S6 Linker of L-Type Ca²⁺ Channel α_1C Subunit (Ca_V 1.2) in Binding of Dihydropyridines and Action of Ca²⁺ Channel Agonists

  Shinji Yamaguchi, Boris S. Zhorov, Katsuro Yoshioka, Taku Nagao, Hidenori Ichijo and Satomi Adachi-Akahane

  Molecular Pharmacology August 2003, 64 (2) 235-248; DOI: https://doi.org/10.1124/mol.64.2.235
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  Prostacylin Receptor Activation Inhibits Proliferation of Aortic Smooth Muscle Cells by Regulating cAMP Response Element-Binding Protein- and Pocket Protein-Dependent Cyclin A Gene Expression

  Devashish Kothapalli, Sheryl A. Stewart, Emer M. Smyth, Ijeoma Azonobi, Daniel J. Rader, Ellen Puré and Richard K. Assoian

  Molecular Pharmacology August 2003, 64 (2) 249-258; DOI: https://doi.org/10.1124/mol.64.2.249
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  Anticancer Drug Resistance Induced by Disruption of the Saccharomyces cerevisiae NPR2 Gene: a Novel Component Involved in Cisplatin- and Doxorubicin-Provoked Cell Kill

  Paul W. Schenk, Mariël Brok, Antonius W. M. Boersma, Jourica A. Brandsma, Hans Den Dulk, Herman Burger, Gerrit Stoter, Jaap Brouwer and Kees Nooter

  Molecular Pharmacology August 2003, 64 (2) 259-268; DOI: https://doi.org/10.1124/mol.64.2.259
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  The Mechanism of Action of Aniracetam at Synaptic α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors: Indirect and Direct Effects on Desensitization

  J. Josh Lawrence, Stephan Brenowitz and Laurence O. Trussell

  Molecular Pharmacology August 2003, 64 (2) 269-278; DOI: https://doi.org/10.1124/mol.64.2.269
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  Carboxylesterase-Mediated Sensitization of Human Tumor Cells to CPT-11 Cannot Override ABCG2-Mediated Drug Resistance

  Monika Wierdl, Amelia Wall, Christopher L. Morton, Janardhan Sampath, Mary K. Danks, John D. Schuetz and Philip M. Potter

  Molecular Pharmacology August 2003, 64 (2) 279-288; DOI: https://doi.org/10.1124/mol.64.2.279
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  P53-Dependent Cell-Killing by Selective Repression of Thymidine Kinase and Reduced Prodrug Activation

  Dong Xu, Deitmar Falke and R. L. Juliano

  Molecular Pharmacology August 2003, 64 (2) 289-297; DOI: https://doi.org/10.1124/mol.64.2.289
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  Isoprostane-Mediated Secretion from Human Airway Epithelial Cells

  Elizabeth A. Cowley

  Molecular Pharmacology August 2003, 64 (2) 298-307; DOI: https://doi.org/10.1124/mol.64.2.298
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  c-Jun NH₂-Terminal Kinase Inhibitor Anthra(1,9-cd)pyrazol-6(2H)-one Reduces Inducible Nitric-Oxide Synthase Expression by Destabilizing mRNA in Activated Macrophages

  Aleksi Lahti, Ulla Jalonen, Hannu Kankaanranta and Eeva Moilanen

  Molecular Pharmacology August 2003, 64 (2) 308-315; DOI: https://doi.org/10.1124/mol.64.2.308
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  Identification of Constitutive Androstane Receptor and Glucocorticoid Receptor Binding Sites in the CYP2C19 Promoter

  Yuping Chen, Stephen S. Ferguson, Masahiko Negishi and Joyce A. Goldstein

  Molecular Pharmacology August 2003, 64 (2) 316-324; DOI: https://doi.org/10.1124/mol.64.2.316
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  High-Affinity Partial Agonists of the Vanilloid Receptor

  Yun Wang, Attila Toth, Richard Tran, Tamas Szabo, Jacqueline D. Welter, Peter M. Blumberg, Jiyoun Lee, Sang-Uk Kang, Ju-Ok Lim and Jeewoo Lee

  Molecular Pharmacology August 2003, 64 (2) 325-333; DOI: https://doi.org/10.1124/mol.64.2.325
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  Preservation of Caspase-3 Subunits from Degradation Contributes to Apoptosis Evoked by Lactacystin: Any Single Lysine or Lysine Pair of the Small Subunit Is Sufficient for Ubiquitination

  Lei Chen, Lucinda Smith, Zhi Wang and Jeffrey B. Smith

  Molecular Pharmacology August 2003, 64 (2) 334-345; DOI: https://doi.org/10.1124/mol.64.2.334
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  Oltipraz Is a Bifunctional Inducer Activating Both Phase I and Phase II Drug-Metabolizing Enzymes via the Xenobiotic Responsive Element

  Weimin Miao, Lianggao Hu, Mustapha Kandouz and Gerald Batist

  Molecular Pharmacology August 2003, 64 (2) 346-354; DOI: https://doi.org/10.1124/mol.64.2.346
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  Down-Regulation of STAT5b Transcriptional Activity by Ligand-Activated Peroxisome Proliferator-Activated Receptor (PPAR) α and PPARγ

  Jonathan M. Shipley and David J. Waxman

  Molecular Pharmacology August 2003, 64 (2) 355-364; DOI: https://doi.org/10.1124/mol.64.2.355
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  Cholesterol Antagonizes Ethanol Potentiation of Human Brain BK_Ca Channels Reconstituted into Phospholipid Bilayers

  John J. Crowley, Steven N. Treistman and Alejandro M. Dopico

  Molecular Pharmacology August 2003, 64 (2) 365-372; DOI: https://doi.org/10.1124/mol.64.2.365
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  Isoflurane and Propofol Inhibit Voltage-Gated Sodium Channels in Isolated Rat Neurohypophysial Nerve Terminals

  Wei Ouyang, Gang Wang and Hugh C. Hemmings

  Molecular Pharmacology August 2003, 64 (2) 373-381; DOI: https://doi.org/10.1124/mol.64.2.373
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  Molecular Modes of Action of Artesunate in Tumor Cell Lines

  Thomas Efferth, Axel Sauerbrey, Armin Olbrich, Erich Gebhart, Pia Rauch, H. Oliver Weber, Jan G. Hengstler, Marc-Eric Halatsch, Manfred Volm, Kenneth D. Tew, Douglas D. Ross and Jens Oliver Funk

  Molecular Pharmacology August 2003, 64 (2) 382-394; DOI: https://doi.org/10.1124/mol.64.2.382
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  Desensitization of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors Facilitates Use-Dependent Inhibition by Pentobarbital

  Michael F. Jackson, Daisy T. Joo, Azza A. Al-Mahrouki, Beverley A. Orser and John F. Macdonald

  Molecular Pharmacology August 2003, 64 (2) 395-406; DOI: https://doi.org/10.1124/mol.64.2.395
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  Aspirin Protects Caco-2 Cells from Apoptosis after Serum Deprivation through the Activation of a Phosphatidylinositol 3-Kinase/AKT/p21^Cip/WAF1Pathway

  Paolo Ricchi, Antonella Di Palma, Tiziana Di Matola, Anna Apicella, Rosaria Fortunato, Raffaele Zarrilli and Angela Maria Acquaviva

  Molecular Pharmacology August 2003, 64 (2) 407-414; DOI: https://doi.org/10.1124/mol.64.2.407
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  Thalidomide Down-Regulates Transcript Levels of GC-Rich Promoter Genes in Multiple Myeloma

  Liat Drucker, Orit Uziel, Tali Tohami, Hava Shapiro, Judith Radnay, Shai Yarkoni, Meir Lahav and Michael Lishner

  Molecular Pharmacology August 2003, 64 (2) 415-420; DOI: https://doi.org/10.1124/mol.64.2.415
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  Differential Involvement of Intracellular Domains of the Rat NTS1 Neurotensin Receptor in Coupling to G Proteins: A Molecular Basis for Agonist-Directed Trafficking of Receptor Stimulus

  Delphine Skrzydelski, Anne-Marie Lhiaubet, Antony Lebeau, Patricia Forgez, Misa Yamada, Emmanuel Hermans, William Rostene and Didier Pelaprat

  Molecular Pharmacology August 2003, 64 (2) 421-429; DOI: https://doi.org/10.1124/mol.64.2.421
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  Dissociation of High-Affinity Cocaine Analog Binding and Dopamine Uptake Inhibition at the Dopamine Transporter

  Wenfei Wang, Mark S. Sonders, Okechukwu T. Ukairo, Helen Scott, Megan K. Kloetzel and Christopher K. Surratt

  Molecular Pharmacology August 2003, 64 (2) 430-439; DOI: https://doi.org/10.1124/mol.64.2.430
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  A Human Serotonin Transporter Mutation Causes Constitutive Activation of Transport Activity

  Fusun Kilic, Dennis L. Murphy and Gary Rudnick

  Molecular Pharmacology August 2003, 64 (2) 440-446; DOI: https://doi.org/10.1124/mol.64.2.440
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  Requirement of Gβγ and c-Src in D2 Dopamine Receptor-Mediated Nuclear Factor-κB Activation

  Ming Yang, Hongmei Zhang, Tatyana Voyno-Yasenetskaya and Richard D. Ye

  Molecular Pharmacology August 2003, 64 (2) 447-455; DOI: https://doi.org/10.1124/mol.64.2.447
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  Msh2 Deficiency Attenuates But Does Not Abolish Thiopurine Hematopoietic Toxicity in Msh2^-/- Mice

  Natalia F. Krynetskaia, Timothy L. Brenner, Eugene Y. Krynetski, Weinan Du, John C. Panetta, Pui Ching-Hon and William E. Evans

  Molecular Pharmacology August 2003, 64 (2) 456-465; DOI: https://doi.org/10.1124/mol.64.2.456
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  The Copper Export Pump ATP7B Modulates the Cellular Pharmacology of Carboplatin in Ovarian Carcinoma Cells

  Kuniyuki Katano, Roohangiz Safaei, Goli Samimi, Alison Holzer, Myriam Rochdi and Stephen B. Howell

  Molecular Pharmacology August 2003, 64 (2) 466-473; DOI: https://doi.org/10.1124/mol.64.2.466
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  The Environmental Pollutant 1,1-Dichloro-2,2-bis (p-chlorophenyl)ethylene Induces Rat Hepatic Cytochrome P450 2B and 3A Expression through the Constitutive Androstane Receptor and Pregnane X Receptor

  Michael E. Wyde, Erika Bartolucci, Akiko Ueda, He Zhang, Binfang Yan, Masahiko Negishi and Li You

  Molecular Pharmacology August 2003, 64 (2) 474-481; DOI: https://doi.org/10.1124/mol.64.2.474
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  Polymorphisms in Human Soluble Epoxide Hydrolase

  Beata D. Przybyla-Zawislak, Punit K. Srivastava, Johana Vázquez-Matías, Harvey W. Mohrenweiser, Joseph E. Maxwell, Bruce D. Hammock, J. Alyce Bradbury, Ahmed E. Enayetallah, Darryl C. Zeldin and David F. Grant

  Molecular Pharmacology August 2003, 64 (2) 482-490; DOI: https://doi.org/10.1124/mol.64.2.482
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  Molecular Determinants of Ca²⁺ Potentiation of Diltiazem Block and Ca²⁺-Dependent Inactivation in the Pore Region of Ca_v1.2

  Nejmi Dilmac, Nathan Hilliard and Gregory H. Hockerman

  Molecular Pharmacology August 2003, 64 (2) 491-501; DOI: https://doi.org/10.1124/mol.64.2.491
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  Prevalence of Necrosis in C₂-Ceramide–Induced Cytotoxicity in NB16 Neuroblastoma Cells

  Belén Ramos, Jill M. Lahti, Enrique Claro and Suzanne Jackowski

  Molecular Pharmacology August 2003, 64 (2) 502-511; DOI: https://doi.org/10.1124/mol.64.2.502
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  Tiotidine, a Histamine H2 Receptor Inverse Agonist That Binds with High Affinity to an Inactive G-Protein—Coupled Form of the Receptor. Experimental Support for the Cubic Ternary Complex Model

  Federico Monczor, Natalia Fernández, Bibiana Lemos Legnazzi, Maria Eugenia Riveiro, Alberto Baldi, Carina Shayo and Carlos Davio

  Molecular Pharmacology August 2003, 64 (2) 512-520; DOI: https://doi.org/10.1124/mol.64.2.512
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  cGMP/Protein Kinase G-Dependent Potentiation of Glutamatergic Transmission Induced by Nitric Oxide in Immature Rat Rostral Ventrolateral Medulla Neurons in Vitro

  Chiung-Chun Huang, Samuel H. H. Chan and Kuei-Sen Hsu

  Molecular Pharmacology August 2003, 64 (2) 521-532; DOI: https://doi.org/10.1124/mol.64.2.521