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Molecular Pharmacology

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Table of Contents

August 01, 2003; Volume 64,Issue 2

Perspectives

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    Center Stage for the Serotonin Transporter: A Gain-of-Function Polymorphism in Persons with Obsessive-Compulsive Disorder
    Gonzalo E. Torres and Marc G. Caron
    Molecular Pharmacology August 2003, 64 (2) 196-198; DOI: https://doi.org/10.1124/mol.64.2.196
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    Sleuthful Pharmacology
    John S. Lazo, Alexander P. Ducruet and Radosevda P. Koldamova
    Molecular Pharmacology August 2003, 64 (2) 199-201; DOI: https://doi.org/10.1124/mol.64.2.199

Articles

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    Painful Inflammation-Induced Increase in μ-Opioid Receptor Binding and G-Protein Coupling in Primary Afferent Neurons
    C. Zöllner, M. A. Shaqura, C. P. Bopaiah, S. Mousa, C. Stein and M. Schäfer
    Molecular Pharmacology August 2003, 64 (2) 202-210; DOI: https://doi.org/10.1124/mol.64.2.202
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    Inhibition of Nuclear Factor κB by Phenolic Antioxidants: Interplay between Antioxidant Signaling and Inflammatory Cytokine Expression
    Qiang Ma, Krista Kinneer, Jianping Ye and Bruce J. Chen
    Molecular Pharmacology August 2003, 64 (2) 211-219; DOI: https://doi.org/10.1124/mol.64.2.211
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    Antifolate Resistance Associated with Loss of MRP1 Expression and Function in Chinese Hamster Ovary Cells with Markedly Impaired Export of Folate and Cholate
    Michal Stark, Lilah Rothem, Gerrit Jansen, George L. Scheffer, I. David Goldman and Yehuda G. Assaraf
    Molecular Pharmacology August 2003, 64 (2) 220-227; DOI: https://doi.org/10.1124/mol.64.2.220
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    Calcium-Dependent Prevention of Neuronal Apoptosis by Lithium Ion: Essential Role of Phosphoinositide 3-Kinase and Phospholipase Cγ
    Hyo Jung Kang, Jai Sung Noh, Yun Soo Bae and Byoung Joo Gwag
    Molecular Pharmacology August 2003, 64 (2) 228-234; DOI: https://doi.org/10.1124/mol.64.2.228
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    Key Roles of Phe1112 and Ser1115 in the Pore-Forming IIIS5-S6 Linker of L-Type Ca2+ Channel α1C Subunit (CaV 1.2) in Binding of Dihydropyridines and Action of Ca2+ Channel Agonists
    Shinji Yamaguchi, Boris S. Zhorov, Katsuro Yoshioka, Taku Nagao, Hidenori Ichijo and Satomi Adachi-Akahane
    Molecular Pharmacology August 2003, 64 (2) 235-248; DOI: https://doi.org/10.1124/mol.64.2.235
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    Prostacylin Receptor Activation Inhibits Proliferation of Aortic Smooth Muscle Cells by Regulating cAMP Response Element-Binding Protein- and Pocket Protein-Dependent Cyclin A Gene Expression
    Devashish Kothapalli, Sheryl A. Stewart, Emer M. Smyth, Ijeoma Azonobi, Daniel J. Rader, Ellen Puré and Richard K. Assoian
    Molecular Pharmacology August 2003, 64 (2) 249-258; DOI: https://doi.org/10.1124/mol.64.2.249
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    Anticancer Drug Resistance Induced by Disruption of the Saccharomyces cerevisiae NPR2 Gene: a Novel Component Involved in Cisplatin- and Doxorubicin-Provoked Cell Kill
    Paul W. Schenk, Mariël Brok, Antonius W. M. Boersma, Jourica A. Brandsma, Hans Den Dulk, Herman Burger, Gerrit Stoter, Jaap Brouwer and Kees Nooter
    Molecular Pharmacology August 2003, 64 (2) 259-268; DOI: https://doi.org/10.1124/mol.64.2.259
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    The Mechanism of Action of Aniracetam at Synaptic α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors: Indirect and Direct Effects on Desensitization
    J. Josh Lawrence, Stephan Brenowitz and Laurence O. Trussell
    Molecular Pharmacology August 2003, 64 (2) 269-278; DOI: https://doi.org/10.1124/mol.64.2.269
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    Carboxylesterase-Mediated Sensitization of Human Tumor Cells to CPT-11 Cannot Override ABCG2-Mediated Drug Resistance
    Monika Wierdl, Amelia Wall, Christopher L. Morton, Janardhan Sampath, Mary K. Danks, John D. Schuetz and Philip M. Potter
    Molecular Pharmacology August 2003, 64 (2) 279-288; DOI: https://doi.org/10.1124/mol.64.2.279
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    P53-Dependent Cell-Killing by Selective Repression of Thymidine Kinase and Reduced Prodrug Activation
    Dong Xu, Deitmar Falke and R. L. Juliano
    Molecular Pharmacology August 2003, 64 (2) 289-297; DOI: https://doi.org/10.1124/mol.64.2.289
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    Isoprostane-Mediated Secretion from Human Airway Epithelial Cells
    Elizabeth A. Cowley
    Molecular Pharmacology August 2003, 64 (2) 298-307; DOI: https://doi.org/10.1124/mol.64.2.298
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    c-Jun NH2-Terminal Kinase Inhibitor Anthra(1,9-cd)pyrazol-6(2H)-one Reduces Inducible Nitric-Oxide Synthase Expression by Destabilizing mRNA in Activated Macrophages
    Aleksi Lahti, Ulla Jalonen, Hannu Kankaanranta and Eeva Moilanen
    Molecular Pharmacology August 2003, 64 (2) 308-315; DOI: https://doi.org/10.1124/mol.64.2.308
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    Identification of Constitutive Androstane Receptor and Glucocorticoid Receptor Binding Sites in the CYP2C19 Promoter
    Yuping Chen, Stephen S. Ferguson, Masahiko Negishi and Joyce A. Goldstein
    Molecular Pharmacology August 2003, 64 (2) 316-324; DOI: https://doi.org/10.1124/mol.64.2.316
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    High-Affinity Partial Agonists of the Vanilloid Receptor
    Yun Wang, Attila Toth, Richard Tran, Tamas Szabo, Jacqueline D. Welter, Peter M. Blumberg, Jiyoun Lee, Sang-Uk Kang, Ju-Ok Lim and Jeewoo Lee
    Molecular Pharmacology August 2003, 64 (2) 325-333; DOI: https://doi.org/10.1124/mol.64.2.325
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    Preservation of Caspase-3 Subunits from Degradation Contributes to Apoptosis Evoked by Lactacystin: Any Single Lysine or Lysine Pair of the Small Subunit Is Sufficient for Ubiquitination
    Lei Chen, Lucinda Smith, Zhi Wang and Jeffrey B. Smith
    Molecular Pharmacology August 2003, 64 (2) 334-345; DOI: https://doi.org/10.1124/mol.64.2.334
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    Oltipraz Is a Bifunctional Inducer Activating Both Phase I and Phase II Drug-Metabolizing Enzymes via the Xenobiotic Responsive Element
    Weimin Miao, Lianggao Hu, Mustapha Kandouz and Gerald Batist
    Molecular Pharmacology August 2003, 64 (2) 346-354; DOI: https://doi.org/10.1124/mol.64.2.346
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    Down-Regulation of STAT5b Transcriptional Activity by Ligand-Activated Peroxisome Proliferator-Activated Receptor (PPAR) α and PPARγ
    Jonathan M. Shipley and David J. Waxman
    Molecular Pharmacology August 2003, 64 (2) 355-364; DOI: https://doi.org/10.1124/mol.64.2.355
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    Cholesterol Antagonizes Ethanol Potentiation of Human Brain BKCa Channels Reconstituted into Phospholipid Bilayers
    John J. Crowley, Steven N. Treistman and Alejandro M. Dopico
    Molecular Pharmacology August 2003, 64 (2) 365-372; DOI: https://doi.org/10.1124/mol.64.2.365
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    Isoflurane and Propofol Inhibit Voltage-Gated Sodium Channels in Isolated Rat Neurohypophysial Nerve Terminals
    Wei Ouyang, Gang Wang and Hugh C. Hemmings
    Molecular Pharmacology August 2003, 64 (2) 373-381; DOI: https://doi.org/10.1124/mol.64.2.373
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    Molecular Modes of Action of Artesunate in Tumor Cell Lines
    Thomas Efferth, Axel Sauerbrey, Armin Olbrich, Erich Gebhart, Pia Rauch, H. Oliver Weber, Jan G. Hengstler, Marc-Eric Halatsch, Manfred Volm, Kenneth D. Tew, Douglas D. Ross and Jens Oliver Funk
    Molecular Pharmacology August 2003, 64 (2) 382-394; DOI: https://doi.org/10.1124/mol.64.2.382
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    Desensitization of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors Facilitates Use-Dependent Inhibition by Pentobarbital
    Michael F. Jackson, Daisy T. Joo, Azza A. Al-Mahrouki, Beverley A. Orser and John F. Macdonald
    Molecular Pharmacology August 2003, 64 (2) 395-406; DOI: https://doi.org/10.1124/mol.64.2.395
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    Aspirin Protects Caco-2 Cells from Apoptosis after Serum Deprivation through the Activation of a Phosphatidylinositol 3-Kinase/AKT/p21Cip/WAF1Pathway
    Paolo Ricchi, Antonella Di Palma, Tiziana Di Matola, Anna Apicella, Rosaria Fortunato, Raffaele Zarrilli and Angela Maria Acquaviva
    Molecular Pharmacology August 2003, 64 (2) 407-414; DOI: https://doi.org/10.1124/mol.64.2.407
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    Thalidomide Down-Regulates Transcript Levels of GC-Rich Promoter Genes in Multiple Myeloma
    Liat Drucker, Orit Uziel, Tali Tohami, Hava Shapiro, Judith Radnay, Shai Yarkoni, Meir Lahav and Michael Lishner
    Molecular Pharmacology August 2003, 64 (2) 415-420; DOI: https://doi.org/10.1124/mol.64.2.415
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    Differential Involvement of Intracellular Domains of the Rat NTS1 Neurotensin Receptor in Coupling to G Proteins: A Molecular Basis for Agonist-Directed Trafficking of Receptor Stimulus
    Delphine Skrzydelski, Anne-Marie Lhiaubet, Antony Lebeau, Patricia Forgez, Misa Yamada, Emmanuel Hermans, William Rostene and Didier Pelaprat
    Molecular Pharmacology August 2003, 64 (2) 421-429; DOI: https://doi.org/10.1124/mol.64.2.421
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    Dissociation of High-Affinity Cocaine Analog Binding and Dopamine Uptake Inhibition at the Dopamine Transporter
    Wenfei Wang, Mark S. Sonders, Okechukwu T. Ukairo, Helen Scott, Megan K. Kloetzel and Christopher K. Surratt
    Molecular Pharmacology August 2003, 64 (2) 430-439; DOI: https://doi.org/10.1124/mol.64.2.430
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    A Human Serotonin Transporter Mutation Causes Constitutive Activation of Transport Activity
    Fusun Kilic, Dennis L. Murphy and Gary Rudnick
    Molecular Pharmacology August 2003, 64 (2) 440-446; DOI: https://doi.org/10.1124/mol.64.2.440
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    Requirement of Gβγ and c-Src in D2 Dopamine Receptor-Mediated Nuclear Factor-κB Activation
    Ming Yang, Hongmei Zhang, Tatyana Voyno-Yasenetskaya and Richard D. Ye
    Molecular Pharmacology August 2003, 64 (2) 447-455; DOI: https://doi.org/10.1124/mol.64.2.447
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    Msh2 Deficiency Attenuates But Does Not Abolish Thiopurine Hematopoietic Toxicity in Msh2-/- Mice
    Natalia F. Krynetskaia, Timothy L. Brenner, Eugene Y. Krynetski, Weinan Du, John C. Panetta, Pui Ching-Hon and William E. Evans
    Molecular Pharmacology August 2003, 64 (2) 456-465; DOI: https://doi.org/10.1124/mol.64.2.456
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    The Copper Export Pump ATP7B Modulates the Cellular Pharmacology of Carboplatin in Ovarian Carcinoma Cells
    Kuniyuki Katano, Roohangiz Safaei, Goli Samimi, Alison Holzer, Myriam Rochdi and Stephen B. Howell
    Molecular Pharmacology August 2003, 64 (2) 466-473; DOI: https://doi.org/10.1124/mol.64.2.466
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    The Environmental Pollutant 1,1-Dichloro-2,2-bis (p-chlorophenyl)ethylene Induces Rat Hepatic Cytochrome P450 2B and 3A Expression through the Constitutive Androstane Receptor and Pregnane X Receptor
    Michael E. Wyde, Erika Bartolucci, Akiko Ueda, He Zhang, Binfang Yan, Masahiko Negishi and Li You
    Molecular Pharmacology August 2003, 64 (2) 474-481; DOI: https://doi.org/10.1124/mol.64.2.474
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    Polymorphisms in Human Soluble Epoxide Hydrolase
    Beata D. Przybyla-Zawislak, Punit K. Srivastava, Johana Vázquez-Matías, Harvey W. Mohrenweiser, Joseph E. Maxwell, Bruce D. Hammock, J. Alyce Bradbury, Ahmed E. Enayetallah, Darryl C. Zeldin and David F. Grant
    Molecular Pharmacology August 2003, 64 (2) 482-490; DOI: https://doi.org/10.1124/mol.64.2.482
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    Molecular Determinants of Ca2+ Potentiation of Diltiazem Block and Ca2+-Dependent Inactivation in the Pore Region of Cav1.2
    Nejmi Dilmac, Nathan Hilliard and Gregory H. Hockerman
    Molecular Pharmacology August 2003, 64 (2) 491-501; DOI: https://doi.org/10.1124/mol.64.2.491
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    Prevalence of Necrosis in C2-Ceramide–Induced Cytotoxicity in NB16 Neuroblastoma Cells
    Belén Ramos, Jill M. Lahti, Enrique Claro and Suzanne Jackowski
    Molecular Pharmacology August 2003, 64 (2) 502-511; DOI: https://doi.org/10.1124/mol.64.2.502
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    Tiotidine, a Histamine H2 Receptor Inverse Agonist That Binds with High Affinity to an Inactive G-Protein—Coupled Form of the Receptor. Experimental Support for the Cubic Ternary Complex Model
    Federico Monczor, Natalia Fernández, Bibiana Lemos Legnazzi, Maria Eugenia Riveiro, Alberto Baldi, Carina Shayo and Carlos Davio
    Molecular Pharmacology August 2003, 64 (2) 512-520; DOI: https://doi.org/10.1124/mol.64.2.512
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    cGMP/Protein Kinase G-Dependent Potentiation of Glutamatergic Transmission Induced by Nitric Oxide in Immature Rat Rostral Ventrolateral Medulla Neurons in Vitro
    Chiung-Chun Huang, Samuel H. H. Chan and Kuei-Sen Hsu
    Molecular Pharmacology August 2003, 64 (2) 521-532; DOI: https://doi.org/10.1124/mol.64.2.521
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Molecular Pharmacology: 64 (2)
Molecular Pharmacology
Vol. 64, Issue 2
1 Aug 2003
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  • Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines.
  • The Orphan Human Pregnane X Receptor Mediates the Transcriptional Activation of CYP3A4 by Rifampicin through a Distal Enhancer Module
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