Molecular Pharmacology: 64 (3)

September 01, 2003; Volume 64,Issue 3

MINIREVIEW

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Cyclic Nucleotide Phosphodiesterase Activity, Expression, and Targeting in Cells of the Cardiovascular System
Donald H. Maurice, Daniel Palmer, Douglas G. Tilley, Heather A. Dunkerley, Stuart J. Netherton, Daniel R. Raymond, Hisham S. Elbatarny and Sandra L. Jimmo

Molecular Pharmacology September 2003, 64 (3) 533-546; DOI: https://doi.org/10.1124/mol.64.3.533

Perspective

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RGS Protein and G Protein Interactions: A Little Help from Their Friends
John R. Hepler

Molecular Pharmacology September 2003, 64 (3) 547-549; DOI: https://doi.org/10.1124/mol.64.3.547

Accelerated Communication

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Aspartate Aminotransferase Generates Proagonists of the Aryl Hydrocarbon Receptor
Mark A. Bittinger, Linh P. Nguyen and Christopher A. Bradfield

Molecular Pharmacology September 2003, 64 (3) 550-556; DOI: https://doi.org/10.1124/mol.64.3.550

Articles

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Critical Role for Akt1 in the Modulation of Apoptotic Phosphatidylserine Exposure and Microglial Activation
Jing-Qiong Kang, Zhao Zhong Chong and Kenneth Maiese

Molecular Pharmacology September 2003, 64 (3) 557-569; DOI: https://doi.org/10.1124/mol.64.3.557
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Membrane Assembly of the Cannabinoid Receptor 1: Impact of a Long N-Terminal Tail
Helena Andersson, Aaron M. D'Antona, Debra A. Kendall, Gunnar Von Heijne and Chen-Ni Chin

Molecular Pharmacology September 2003, 64 (3) 570-577; DOI: https://doi.org/10.1124/mol.64.3.570
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Prevention of Dopaminergic Neuronal Death by Cyclic AMP in Mixed Neuronal/Glial Mesencephalic Cultures Requires the Repression of Presumptive Astrocytes
Sophie Mourlevat, Jean-Denis Troadec, Merle Ruberg and Patrick P. Michel

Molecular Pharmacology September 2003, 64 (3) 578-586; DOI: https://doi.org/10.1124/mol.64.3.578
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Recruitment of RGS2 and RGS4 to the Plasma Membrane by G Proteins and Receptors Reflects Functional Interactions
Anju Anne Roy, Kara E. Lemberg and Peter Chidiac

Molecular Pharmacology September 2003, 64 (3) 587-593; DOI: https://doi.org/10.1124/mol.64.3.587
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Mouse κ-Opioid Receptor mRNA Differential Transport in Neurons
Jing Bi, Xinli Hu, Horace H. Loh and Li-Na Wei

Molecular Pharmacology September 2003, 64 (3) 594-599; DOI: https://doi.org/10.1124/mol.64.3.594
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Metal-Dependent Inhibition of HIV-1 Integrase by β-Diketo Acids and Resistance of the Soluble Double-Mutant (F185K/C280S)
Christophe Marchand, Allison A. Johnson, Rajeshri G. Karki, Godwin C. G. Pais, Xuechun Zhang, Kiriana Cowansage, Tapan A. Patel, Marc C. Nicklaus, Terrence R. Burke and Yves Pommier

Molecular Pharmacology September 2003, 64 (3) 600-609; DOI: https://doi.org/10.1124/mol.64.3.600
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Breast Cancer Resistance Protein Exports Sulfated Estrogens but Not Free Estrogens
Yasuo Imai, Sakiyo Asada, Satomi Tsukahara, Etsuko Ishikawa, Takashi Tsuruo and Yoshikazu Sugimoto

Molecular Pharmacology September 2003, 64 (3) 610-618; DOI: https://doi.org/10.1124/mol.64.3.610
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l-DOPA Treatment Modulates Nicotinic Receptors in Monkey Striatum
Maryka Quik, Tanuja Bordia, Michaella Okihara, Hong Fan, Michael J. Marks, J. Michael McIntosh and Paul Whiteaker

Molecular Pharmacology September 2003, 64 (3) 619-628; DOI: https://doi.org/10.1124/mol.64.3.619
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Involvement of Intramolecular Interactions in the Regulation of G Protein-Coupled Receptor Kinase 2
Susana Sarnago, Ramón Roca, Antonio De Blasi, Alfonso Valencia, Federico Mayor and Cristina Murga

Molecular Pharmacology September 2003, 64 (3) 629-639; DOI: https://doi.org/10.1124/mol.64.3.629
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Adenosine-A2a Receptor Down-Regulates Cerebral Smooth Muscle L-Type Ca²⁺ Channel Activity via Protein Tyrosine Phosphatase, Not cAMP-Dependent Protein Kinase
Katrina Murphy, Volodymyr Gerzanich, Hui Zhou, Svetlana Ivanova, Yafeng Dong, Gloria Hoffman, G. Alexander West, H. Richard Winn and J. Marc Simard

Molecular Pharmacology September 2003, 64 (3) 640-649; DOI: https://doi.org/10.1124/mol.64.3.640
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Agonist-Induced Conformational Changes in the Extracellular Domain of α7 Nicotinic Acetylcholine Receptors
Lisa K. Lyford, Adrian D. Sproul, Donnie Eddins, James T. McLaughlin and Robert L. Rosenberg

Molecular Pharmacology September 2003, 64 (3) 650-658; DOI: https://doi.org/10.1124/mol.64.3.650
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Genetic Polymorphism of CYP1A2 in Ethiopians Affecting Induction and Expression: Characterization of Novel Haplotypes with Single-Nucleotide Polymorphisms in Intron 1
Eleni Aklillu, Juan Antonio Carrillo, Eyasu Makonnen, Karin Hellman, Marià Pitarque, Leif Bertilsson and Magnus Ingelman-Sundberg

Molecular Pharmacology September 2003, 64 (3) 659-669; DOI: https://doi.org/10.1124/mol.64.3.659
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The Metabolites of the Cardioprotective Drug Dexrazoxane Do Not Protect Myocytes from Doxorubicin-Induced Cytotoxicity
Brian B. Hasinoff, Patricia E. Schroeder and Daywin Patel

Molecular Pharmacology September 2003, 64 (3) 670-678; DOI: https://doi.org/10.1124/mol.64.3.670
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Influence of Agonist Efficacy and Receptor Phosphorylation on Antagonist Affinity Measurements: Differences between Second Messenger and Reporter Gene Responses
Jillian G. Baker, Ian P. Hall and Stephen J. Hill

Molecular Pharmacology September 2003, 64 (3) 679-688; DOI: https://doi.org/10.1124/mol.64.3.679
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Characterization of Ca²⁺ Channels and G Proteins Involved in Arachidonic Acid Release by Endothelin-1/Endothelin_A Receptor
Yoshifumi Kawanabe, Kazuhiko Nozaki, Nobuo Hashimoto and Tomoh Masaki

Molecular Pharmacology September 2003, 64 (3) 689-695; DOI: https://doi.org/10.1124/mol.64.3.689
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Low Molecular Weight Fucoidan and Heparin Enhance the Basic Fibroblast Growth Factor-Induced Tube Formation of Endothelial Cells through Heparan Sulfate-Dependent α6 Overexpression
Delphine Chabut, Anne-Marie Fischer, Sylvia Colliec-Jouault, Ingrid Laurendeau, Sabine Matou, Bernard Le Bonniec and Dominique Helley

Molecular Pharmacology September 2003, 64 (3) 696-702; DOI: https://doi.org/10.1124/mol.64.3.696
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Stargazin Differentially Controls the Trafficking of α-Amino-3-hydroxyl-5-methyl-4-isoxazolepropionate and Kainate Receptors
Lu Chen, Alaa El-Husseini, Susumu Tomita, David S. Bredt and Roger A. Nicoll

Molecular Pharmacology September 2003, 64 (3) 703-706; DOI: https://doi.org/10.1124/mol.64.3.703
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5-Fluorouracil Blocks Transforming Growth Factor-β–Induced α₂ Type I Collagen Gene (COL1A2) Expression in Human Fibroblasts via c-Jun NH₂-Terminal Kinase/Activator Protein-1 Activation
Jeanne Wendling, Aimé Marchand, Alain Mauviel and Franck Verrecchia

Molecular Pharmacology September 2003, 64 (3) 707-713; DOI: https://doi.org/10.1124/mol.64.3.707
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Biochemical, Cytotoxic, and Genotoxic Effects of ES936, a Mechanism-Based Inhibitor of NAD(P)H:quinone Oxidoreductase 1, in Cellular Systems
Donna L. Dehn, David Siegel, Elizabeth Swann, Christopher J. Moody and David Ross

Molecular Pharmacology September 2003, 64 (3) 714-720; DOI: https://doi.org/10.1124/mol.64.3.714
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Differential Signaling of Formyl Peptide Receptor-Like 1 by Trp-Lys-Tyr-Met-Val-Met-CONH₂ or Lipoxin A4 in Human Neutrophils
Yoe-Sik Bae, Jun Chul Park, Rong He, Richard D. Ye, Jong-Young Kwak, Pann-Ghill Suh and Sung Ho Ryu

Molecular Pharmacology September 2003, 64 (3) 721-730; DOI: https://doi.org/10.1124/mol.64.3.721
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A Family of Highly Selective Allosteric Modulators of the Metabotropic Glutamate Receptor Subtype 5
Julie A. O'Brien, Wei Lemaire, Tsing-Bau Chen, Raymond S. L. Chang, Marlene A. Jacobson, Sookhee N. Ha, Craig W. Lindsley, Hervé J. Schaffhauser, Cyrille Sur, Douglas J. Pettibone, P. Jeffrey Conn and David L. Williams

Molecular Pharmacology September 2003, 64 (3) 731-740; DOI: https://doi.org/10.1124/mol.64.3.731
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Altered Gating and Local Anesthetic Block Mediated by Residues in the I-S6 and II-S6 Transmembrane Segments of Voltage-Dependent Na⁺ Channels
Andrei Kondratiev and Gordon F. Tomaselli

Molecular Pharmacology September 2003, 64 (3) 741-752; DOI: https://doi.org/10.1124/mol.64.3.741
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Receptor Subtype-Dependent Positive and Negative Modulation of GABA_A Receptor Function by Niflumic Acid, a Nonsteroidal Anti-Inflammatory Drug
Saku T. Sinkkonen, Salla Mansikkamäki, Tommi Möykkynen, Hartmut Lüddens, Mikko Uusi-Oukari and Esa R. Korpi

Molecular Pharmacology September 2003, 64 (3) 753-763; DOI: https://doi.org/10.1124/mol.64.3.753
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Down-Regulation of Acyl-CoA Oxidase Gene Expression in Heart of Troglitazone-Treated Mice through a Mechanism Involving Chicken Ovalbumin Upstream Promoter Transcription Factor II
Àgatha Cabrero, Mireia Jové, Anna Planavila, Manuel Merlos, Juan C. Laguna and Manuel Vázquez-Carrera

Molecular Pharmacology September 2003, 64 (3) 764-772; DOI: https://doi.org/10.1124/mol.64.3.764
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Signaling Pathways for Monocyte Chemoattractant Protein 1-Mediated Extracellular Signal-Regulated Kinase Activation
M. Carmen Jiménez-Sainz, Beate Fast, Federico Mayor and Anna M. Aragay

Molecular Pharmacology September 2003, 64 (3) 773-782; DOI: https://doi.org/10.1124/mol.64.3.773

Errata

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Correction to “Prostacylin receptor activation inhibits proliferation of aortic smooth muscle cells by regulating cAMP response element-binding protein- and pocket protein-dependent cyclin A gene expression”
Molecular Pharmacology September 2003, 64 (3) 783; DOI: https://doi.org/10.1124/mol.64.3.783
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Correction to “Enhancement of long-term potentiation by a potent nitric oxide-guanylyl cyclase activator, 3-(5-hydroxymethyl-2-furyl)-1-benzyl-indazole”
Molecular Pharmacology September 2003, 64 (3) 784; DOI: https://doi.org/10.1124/mol.64.3.784

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