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Research ArticleArticle

Metal-Dependent Inhibition of HIV-1 Integrase by β-Diketo Acids and Resistance of the Soluble Double-Mutant (F185K/C280S)

Christophe Marchand, Allison A. Johnson, Rajeshri G. Karki, Godwin C. G. Pais, Xuechun Zhang, Kiriana Cowansage, Tapan A. Patel, Marc C. Nicklaus, Terrence R. Burke Jr. and Yves Pommier
Molecular Pharmacology September 2003, 64 (3) 600-609; DOI: https://doi.org/10.1124/mol.64.3.600

Article Information

vol. 64 no. 3 600-609
DOI 
https://doi.org/10.1124/mol.64.3.600
PubMed 
12920196
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received February 24, 2003
  • Accepted May 30, 2003
  • Published online August 14, 2003.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Christophe Marchand,
  2. Allison A. Johnson,
  3. Rajeshri G. Karki,
  4. Godwin C. G. Pais,
  5. Xuechun Zhang,
  6. Kiriana Cowansage,
  7. Tapan A. Patel,
  8. Marc C. Nicklaus,
  9. Terrence R. Burke Jr. and
  10. Yves Pommier
  1. Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (C.M., A.A.J., K.C., T.A.P., Y.P.); and Laboratory of Medicinal Chemistry, Center for Cancer Research, National Cancer Institute, Frederick, Maryland (R.G.K., G.C.G.P., X.Z., M.C.N., T.R.B.)
  1. Address correspondence to:
    Dr. Yves Pommier, Laboratory of Molecular Pharmacology, Center for Cancer Research, Bldg. 37, Rm. 5068, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4255. E-mail: pommier{at}nih.gov
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Research ArticleArticle

Metal-Dependent Inhibition of HIV-1 Integrase by β-Diketo Acids and Resistance of the Soluble Double-Mutant (F185K/C280S)

Christophe Marchand, Allison A. Johnson, Rajeshri G. Karki, Godwin C. G. Pais, Xuechun Zhang, Kiriana Cowansage, Tapan A. Patel, Marc C. Nicklaus, Terrence R. Burke and Yves Pommier
Molecular Pharmacology September 1, 2003, 64 (3) 600-609; DOI: https://doi.org/10.1124/mol.64.3.600
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