Table of Contents

Articles

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  Pharmacological Characterization and Identification of Amino Acids Involved in the Positive Modulation of Metabotropic Glutamate Receptor Subtype 2

  Hervé Schaffhauser, Blake A. Rowe, Sylvia Morales, Laura E. Chavez-Noriega, Ruoyuan Yin, Christine Jachec, Sara P. Rao, Gretchen Bain, Anthony B. Pinkerton, Jean-Michel Vernier, Linda J. Bristow, Mark A. Varney and Lorrie P. Daggett

  Molecular Pharmacology October 2003, 64 (4) 798-810; DOI: https://doi.org/10.1124/mol.64.4.798
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  Pentoxifylline Inhibits Platelet-Derived Growth Factor-Stimulated Cyclin D1 Expression in Mesangial Cells by Blocking Akt Membrane Translocation

  Shuei-Liong Lin, Ruey-Hwa Chen, Yung-Ming Chen, Wen-Chih Chiang, Tun-Jun Tsai and Bor-Shen Hsieh

  Molecular Pharmacology October 2003, 64 (4) 811-822; DOI: https://doi.org/10.1124/mol.64.4.811
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  Mutational Analysis and Molecular Modeling of the Binding Pocket of the Metabotropic Glutamate 5 Receptor Negative Modulator 2-Methyl-6-(phenylethynyl)-pyridine

  Pari Malherbe, Nicole Kratochwil, Marie-Théeése Zenner, Jenny Piussi, Catherine Diener, Claudia Kratzeisen, Christophe Fischer and Richard H. P. Porter

  Molecular Pharmacology October 2003, 64 (4) 823-832; DOI: https://doi.org/10.1124/mol.64.4.823
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  Up-Regulation of Secretory Leukocyte Protease Inhibitor (SLPI) in the Brain after Ischemic Stroke: Adenoviral Expression of SLPI Protects Brain from Ischemic Injury

  Xinkang Wang, Xiang Li, Lin Xu, Yutian Zhan, Shoshanit Yaish-Ohad, Joseph A. Erhardt, Frank C. Barone and Giora Z. Feuerstein

  Molecular Pharmacology October 2003, 64 (4) 833-840; DOI: https://doi.org/10.1124/mol.64.4.833
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  Differential Activation of Formyl Peptide Receptor Signaling by Peptide Ligands

  Yoe-Sik Bae, Ji Young Song, Youndong Kim, Rong He, Richard D. Ye, Jong-Young Kwak, Pann-Ghill Suh and Sung Ho Ryu

  Molecular Pharmacology October 2003, 64 (4) 841-847; DOI: https://doi.org/10.1124/mol.64.4.841
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  Mutations in the Epithelial Na⁺ Channel ENaC Outer Pore Disrupt Amiloride Block by Increasing Its Dissociation Rate

  Stephan Kellenberger, Ivan Gautschi and Laurent Schild

  Molecular Pharmacology October 2003, 64 (4) 848-856; DOI: https://doi.org/10.1124/mol.64.4.848
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  A Presynaptic Action of the Neurosteroid Pregnenolone Sulfate on GABAergic Synaptic Transmission

  Zakaria Mtchedlishvili and Jaideep Kapur

  Molecular Pharmacology October 2003, 64 (4) 857-864; DOI: https://doi.org/10.1124/mol.64.4.857
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  Carbamoylcholine Homologs: Novel and Potent Agonists at Neuronal Nicotinic Acetylcholine Receptors

  Anders A. Jensen, Ivan Mikkelsen, Bente Frølund, Hans Bräuner-Osborne, Erik Falch and Povl Krogsgaard-Larsen

  Molecular Pharmacology October 2003, 64 (4) 865-875; DOI: https://doi.org/10.1124/mol.64.4.865
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  The Role of Nuclear Factor κB in Tumor Necrosis Factor-Regulated Transcription of the Human μ-Opioid Receptor Gene

  Jürgen Kraus, Christine Börner, Elisa Giannini and Volker Höllt

  Molecular Pharmacology October 2003, 64 (4) 876-884; DOI: https://doi.org/10.1124/mol.64.4.876
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  Functional Nicotinic Acetylcholine Receptors Are Expressed in B Lymphocyte-Derived Cell Lines

  Marina V. Skok, Elena N. Kalashnik, Ludmila N. Koval, Victor I. Tsetlin, Yuriy N. Utkin, Jean-Pierre Changeux and Régis Grailhe

  Molecular Pharmacology October 2003, 64 (4) 885-889; DOI: https://doi.org/10.1124/mol.64.4.885
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  Agonist- and Protein Kinase C-Induced Phosphorylation Have Similar Functional Consequences for Gastrin-Releasing Peptide Receptor Signaling via G_q

  Roxanne A. Ally, Kirk L. Ives, Elie Traube, Iman Eltounsi, Pei-Wen Chen, Patrick J. Cahill, James F. Battey, Mark R. Hellmich and Glenn S. Kroog

  Molecular Pharmacology October 2003, 64 (4) 890-904; DOI: https://doi.org/10.1124/mol.64.4.890
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  Syntaxin 1A Inhibits GABA Flux, Efflux, and Exchange Mediated by the Rat Brain GABA Transporter GAT1

  Dan Wang, Scott L. Deken, Terri L. Whitworth and Michael W. Quick

  Molecular Pharmacology October 2003, 64 (4) 905-913; DOI: https://doi.org/10.1124/mol.64.4.905
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  Mutations of the para Sodium Channel of Drosophila melanogaster Identify Putative Binding Sites for Pyrethroids

  H. Vais, S. Atkinson, F. Pluteanu, S. J. Goodson, A. L. Devonshire, M. S. Williamson and P. N. R. Usherwood

  Molecular Pharmacology October 2003, 64 (4) 914-922; DOI: https://doi.org/10.1124/mol.64.4.914
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  Role for Nuclear Factor-κB and Signal Transducer and Activator of Transcription 1/Interferon Regulatory Factor-1 in Cytokine-Induced Endothelin-1 Release in Human Vascular Smooth Muscle Cells

  Mandy Woods, Elizabeth G. Wood, Sonya C. Bardswell, David Bishop-Bailey, Stewart Barker, Stephen J. Wort, Jane A. Mitchell and Timothy D. Warner

  Molecular Pharmacology October 2003, 64 (4) 923-931; DOI: https://doi.org/10.1124/mol.64.4.923
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  Optimal Requirements for High Affinity and Use-Dependent Block of Skeletal Muscle Sodium Channel by N-Benzyl Analogs of Tocainide-Like Compounds

  Annamaria De Luca, Sophie Talon, Michela De Bellis, Jean-François Desaphy, Giovanni Lentini, Filomena Corbo, Antonio Scilimati, Carlo Franchini, Vincenzo Tortorella and Diana Conte Camerino

  Molecular Pharmacology October 2003, 64 (4) 932-945; DOI: https://doi.org/10.1124/mol.64.4.932
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  Tetrahydrobiopterin Prevents Nitration of Tyrosine Hydroxylase by Peroxynitrite and Nitrogen Dioxide

  Donald M. Kuhn and Timothy J. Geddes

  Molecular Pharmacology October 2003, 64 (4) 946-953; DOI: https://doi.org/10.1124/mol.64.4.946
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  Contrasting Actions of Philanthotoxin-343 and Philanthotoxin-(12) on Human Muscle Nicotinic Acetylcholine Receptors

  Tim J. Brier, Ian R. Mellor, Denis B. Tikhonov, Ioana Neagoe, Zuoyi Shao, Matt J. Brierley, Kristian Strømgaard, Jerzy W. Jaroszewski, Povl Krogsgaard-Larsen and Peter N. R. Usherwood

  Molecular Pharmacology October 2003, 64 (4) 954-964; DOI: https://doi.org/10.1124/mol.64.4.954
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  Inhibition of Protein Kinase Cα Enhances Anticancer Agent-Induced Loss of Anchorage-Independent Growth Regardless of Protection against Apoptosis by Bcl-2

  M. Huigsloot, R. B. Tijdens and B. van de Water

  Molecular Pharmacology October 2003, 64 (4) 965-973; DOI: https://doi.org/10.1124/mol.64.4.965
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  Differential Regulation of Nicotinic Acetylcholine Receptors in PC12 Cells by Nicotine and Nerve Growth Factor

  Amy M. Avila, Martha I. Dávila-García, Veronica S. Ascarrunz, YingxIan Xiao and Kenneth J. Kellar

  Molecular Pharmacology October 2003, 64 (4) 974-986; DOI: https://doi.org/10.1124/mol.64.4.974
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  Role of the Small GTPase Rho in Modulation of the Inwardly Rectifying Potassium Channel Kir2.1.

  S. V. Penelope Jones

  Molecular Pharmacology October 2003, 64 (4) 987-993; DOI: https://doi.org/10.1124/mol.64.4.987
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  Ki16425, a Subtype-Selective Antagonist for EDG-Family Lysophosphatidic Acid Receptors

  Hideo Ohta, Koichi Sato, Naoya Murata, Alatangaole Damirin, Enkhzol Malchinkhuu, Junko Kon, Takao Kimura, Masayuki Tobo, Yuji Yamazaki, Tomoko Watanabe, Mikio Yagi, Motoko Sato, Rika Suzuki, Hideko Murooka, Teruyuki Sakai, Tsuyoshi Nishitoba, Dong-Soon Im, Hiromi Nochi, Koichi Tamoto, Hideaki Tomura and Fumikazu Okajima

  Molecular Pharmacology October 2003, 64 (4) 994-1005; DOI: https://doi.org/10.1124/mol.64.4.994