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Research ArticleArticle

Differences in the Central Nervous System Distribution and Pharmacology of the Mouse 5-Hydroxytryptamine-6 Receptor Compared with Rat and Human Receptors Investigated by Radioligand Binding, Site-Directed Mutagenesis, and Molecular Modeling

Warren D. Hirst, Bjarke Abrahamsen, Frank E. Blaney, Andrew R. Calver, Lucia Aloj, Gary W. Price and Andrew D. Medhurst
Molecular Pharmacology December 2003, 64 (6) 1295-1308; DOI: https://doi.org/10.1124/mol.64.6.1295

Article Information

vol. 64 no. 6 1295-1308
DOI 
https://doi.org/10.1124/mol.64.6.1295
PubMed 
14645659
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received June 26, 2003
  • Accepted August 25, 2003
  • Published online November 26, 2003.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Warren D. Hirst,
  2. Bjarke Abrahamsen,
  3. Frank E. Blaney,
  4. Andrew R. Calver,
  5. Lucia Aloj,
  6. Gary W. Price and
  7. Andrew D. Medhurst
  1. Neurology and GI Centre of Excellence for Drug Discovery (W.D.H., B.A., A.R.C., L.A., A.D.M.), Computational, Analytical and Structural Sciences (F.E.B.), and Psychiatry Centre of Excellence for Drug Discovery (G.W.P.), GlaxoSmithKline, Harlow, Essex, United Kingdom
  1. Address correspondence to:
    Dr. Warren D. Hirst, Neurology and GI Centre of Excellence for Drug Discovery, GlaxoSmithKline, New Frontiers Science Park, Third Avenue, Harlow, Essex, CM19 5AW, United Kingdom. E-mail: Warren.D.Hirst{at}gsk.com
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Research ArticleArticle

Differences in the Central Nervous System Distribution and Pharmacology of the Mouse 5-Hydroxytryptamine-6 Receptor Compared with Rat and Human Receptors Investigated by Radioligand Binding, Site-Directed Mutagenesis, and Molecular Modeling

Warren D. Hirst, Bjarke Abrahamsen, Frank E. Blaney, Andrew R. Calver, Lucia Aloj, Gary W. Price and Andrew D. Medhurst
Molecular Pharmacology December 1, 2003, 64 (6) 1295-1308; DOI: https://doi.org/10.1124/mol.64.6.1295
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