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Molecular Pharmacology

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Table of Contents

January 01, 2004; Volume 65,Issue 1

Articles

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    Editor's Note
    Paul A. Insel
    Molecular Pharmacology January 2004, 65 (1) 1; DOI: https://doi.org/10.1124/mol.65.1.1
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    Limited Gene Activation in Tumor and Normal Epithelial Cells Treated with the DNA Methyltransferase Inhibitor 5-Aza-2′-deoxycytidine
    Adam R. Karpf, Amy W. Lasek, Ted O. Ririe, Adrianne N. Hanks, Douglas Grossman and David A. Jones
    Molecular Pharmacology January 2004, 65 (1) 18-27; DOI: https://doi.org/10.1124/mol.65.1.18
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    Measurement of Intermolecular Distances for the Natural Agonist Peptide Docked at the Cholecystokinin Receptor Expressed in Situ Using Fluorescence Resonance Energy Transfer
    Kaleeckal G. Harikumar, Delia I. Pinon, William S. Wessels, Eric S. Dawson, Terry P. Lybrand, Franklyn G. Prendergast and Laurence J. Miller
    Molecular Pharmacology January 2004, 65 (1) 28-35; DOI: https://doi.org/10.1124/mol.65.1.28
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    Identification of Amino Acids in Rat Pregnane X Receptor that Determine Species-Specific Activation
    Rommel G. Tirona, Brenda F. Leake, Larissa M. Podust and Richard B. Kim
    Molecular Pharmacology January 2004, 65 (1) 36-44; DOI: https://doi.org/10.1124/mol.65.1.36
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    Gene Profiling of Frizzled-1 and Frizzled-2 Signaling: Expression of G-Protein-Coupled Receptor Chimeras in Mouse F9 Teratocarcinoma Embryonal Cells
    Hong Li, Craig C. Malbon and Hsien-Yu Wang
    Molecular Pharmacology January 2004, 65 (1) 45-55; DOI: https://doi.org/10.1124/mol.65.1.45
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    Hydroxy Metabolites of the Alzheimer's Drug Candidate 3-[(2,4-Dimethoxy)Benzylidene]-Anabaseine Dihydrochloride (GTS-21): Their Molecular Properties, Interactions with Brain Nicotinic Receptors, and Brain Penetration
    William R. Kem, Vladimir M. Mahnir, Laszlo Prokai, Roger L. Papke, Xuefang Cao, Susan LeFrancois, Kristin Wildeboer, Katalin Prokai-Tatrai, Julia Porter-Papke and Ferenc Soti
    Molecular Pharmacology January 2004, 65 (1) 56-67; DOI: https://doi.org/10.1124/mol.65.1.56
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    Defining the Propofol Binding Site Location on the GABAA Receptor
    Moez Bali and Myles H. Akabas
    Molecular Pharmacology January 2004, 65 (1) 68-76; DOI: https://doi.org/10.1124/mol.65.1.68
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    Salvinal, a Novel Microtubule Inhibitor Isolated from Salvia miltiorrhizae Bunge (Danshen), with Antimitotic Activity in Multidrug-Sensitive and -Resistant Human Tumor Cells
    Jang-Yang Chang, Chi-Yen Chang, Ching-Chuan Kuo, Li-Tzong Chen, Yung-Shung Wein and Yueh-Hsiung Kuo
    Molecular Pharmacology January 2004, 65 (1) 77-84; DOI: https://doi.org/10.1124/mol.65.1.77
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    Mechanism of HIV-1 Integrase Inhibition by Styrylquinoline Derivatives in Vitro
    Eric Deprez, Sophie Barbe, Macieij Kolaski, Hervé Leh, Fatima Zouhiri, Christian Auclair, Jean-Claude Brochon, Marc Le Bret and Jean-François Mouscadet
    Molecular Pharmacology January 2004, 65 (1) 85-98; DOI: https://doi.org/10.1124/mol.65.1.85
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    Anti-Invasive Gene Expression Profile of Curcumin in Lung Adenocarcinoma Based on a High Throughput Microarray Analysis
    Huei-Wen Chen, Sung-Liang Yu, Jeremy J. W. Chen, Han-Ni Li, Yi-Chen Lin, Pei-Li Yao, Han-Yi Chou, Chiang-Ting Chien, Wen-Jone Chen, Yuan-Teh Lee and Pan-Chyr Yang
    Molecular Pharmacology January 2004, 65 (1) 99-110; DOI: https://doi.org/10.1124/mol.65.1.99
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    Green Tea Inhibits Human Inducible Nitric-Oxide Synthase Expression by Down-Regulating Signal Transducer and Activator of Transcription-1α Activation
    Elisa Tedeschi, Marta Menegazzi, Ying Yao, Hisanori Suzuki, Ulrich Förstermann and Hartmut Kleinert
    Molecular Pharmacology January 2004, 65 (1) 111-120; DOI: https://doi.org/10.1124/mol.65.1.111
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    Dopamine D1-Dependent Trafficking of Striatal N-Methyl-d-aspartate Glutamate Receptors Requires Fyn Protein Tyrosine Kinase but Not DARPP-32
    Anthone W. Dunah, Ana C. Sirianni, Allen A. Fienberg, Elena Bastia, Michael A. Schwarzschild and David. G. Standaert
    Molecular Pharmacology January 2004, 65 (1) 121-129; DOI: https://doi.org/10.1124/mol.65.1.121
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    The Liver-Selective Nitric Oxide Donor O2-Vinyl 1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (V-PYRRO/NO) Protects HepG2 Cells against Cytochrome P450 2E1-Dependent Toxicity
    Pengfei Gong, Arthur I. Cederbaum and Natalia Nieto
    Molecular Pharmacology January 2004, 65 (1) 130-138; DOI: https://doi.org/10.1124/mol.65.1.130
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    Heterogeneity of P2X Receptors in Sympathetic Neurons: Contribution of Neuronal P2X1 Receptors Revealed Using Knockout Mice
    Jennifer A. Calvert and Richard J. Evans
    Molecular Pharmacology January 2004, 65 (1) 139-148; DOI: https://doi.org/10.1124/mol.65.1.139
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    Proteinase-Activated Receptor-2: Key Role of Amino-Terminal Dipeptide Residues of the Tethered Ligand for Receptor Activation
    Bahjat Al-Ani, Kristina K. Hansen and Morley D. Hollenberg
    Molecular Pharmacology January 2004, 65 (1) 149-156; DOI: https://doi.org/10.1124/mol.65.1.149
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    Site within N-Methyl-d-aspartate Receptor Pore Modulates Channel Gating
    Nansheng Chen, Bo Li, Timothy H. Murphy and Lynn A. Raymond
    Molecular Pharmacology January 2004, 65 (1) 157-164; DOI: https://doi.org/10.1124/mol.65.1.157
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    HES-1, a Novel Target Gene for the Aryl Hydrocarbon Receptor
    Jane Sohn Thomsen, Silke Kietz, Anders Ström and Jan-Åke Gustafsson
    Molecular Pharmacology January 2004, 65 (1) 165-171; DOI: https://doi.org/10.1124/mol.65.1.165
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    Transcriptional Regulation of CYP2B1 Induction in Primary Rat Hepatocyte Cultures: Repression by Epidermal Growth Factor Is Mediated via a Distal Enhancer Region
    Daniel Bauer, Nils Wolfram, Georg F. Kahl and Karen I. Hirsch-Ernst
    Molecular Pharmacology January 2004, 65 (1) 172-180; DOI: https://doi.org/10.1124/mol.65.1.172
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    Examination of the Mechanism(s) Involved in Doxorubicin-Mediated Iron Accumulation in Ferritin: Studies Using Metabolic Inhibitors, Protein Synthesis Inhibitors, and Lysosomotropic Agents
    J. C. Kwok and D. R. Richardson
    Molecular Pharmacology January 2004, 65 (1) 181-195; DOI: https://doi.org/10.1124/mol.65.1.181
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    Characterization of Agonist Stimulation of cAMP-Dependent Protein Kinase and G Protein-Coupled Receptor Kinase Phosphorylation of the β2-Adrenergic Receptor Using Phosphoserine-Specific Antibodies
    Tuan M. Tran, Jackie Friedman, Eyad Qunaibi, Faiza Baameur, Robert H. Moore and Richard B. Clark
    Molecular Pharmacology January 2004, 65 (1) 196-206; DOI: https://doi.org/10.1124/mol.65.1.196
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    Characterization of the Human Calcitonin Gene-Related Peptide Receptor Subtypes Associated with Receptor Activity-Modifying Proteins
    Kenji Kuwasako, Yuan-Ning Cao, Yasuko Nagoshi, Toshihiro Tsuruda, Kazuo Kitamura and Tanenao Eto
    Molecular Pharmacology January 2004, 65 (1) 207-213; DOI: https://doi.org/10.1124/mol.65.1.207
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    Novel Neuroprotective K+ Channel Inhibitor Identified by High-Throughput Screening in Yeast
    Elena Zaks-Makhina, Yonjung Kim, Elias Aizenman and Edwin S. Levitan
    Molecular Pharmacology January 2004, 65 (1) 214-219; DOI: https://doi.org/10.1124/mol.65.1.214
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    Human Acetyl CoA:Arylamine N-Acetyltransferase Variants Generated by Random Mutagenesis
    Joanna E. Summerscales and P. David Josephy
    Molecular Pharmacology January 2004, 65 (1) 220-226; DOI: https://doi.org/10.1124/mol.65.1.220
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    The Antileukemia Drug 2-Chloro-2′-deoxyadenosine: An Intrinsic Transcriptional Antagonist
    William R. Hartman and Patricia Hentosh
    Molecular Pharmacology January 2004, 65 (1) 227-234; DOI: https://doi.org/10.1124/mol.65.1.227
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    Quantitative Effects on c-Jun N-Terminal Protein Kinase Signaling Determine Synergistic Interaction of Cisplatin and 17-Allylamino-17-Demethoxygeldanamycin in Colon Cancer Cell Lines
    Irina A. Vasilevskaya, Tatiana V. Rakitina and Peter J. O'Dwyer
    Molecular Pharmacology January 2004, 65 (1) 235-243; DOI: https://doi.org/10.1124/mol.65.1.235
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    Susceptibility of Feline Immunodeficiency Virus/Human Immunodeficiency Virus Type 1 Reverse Transcriptase Chimeras to Non-Nucleoside RT Inhibitors
    Joeri Auwerx, Robert Esnouf, Erik De Clercq and Jan Balzarini
    Molecular Pharmacology January 2004, 65 (1) 244-251; DOI: https://doi.org/10.1124/mol.65.1.244
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    RNA Editing of the Human Serotonin 5-HT2C Receptor Disrupts Transactivation of the Small G-Protein RhoA
    Lori McGrew, Raymond D. Price, Elizabeth Hackler, Mike S. S. Chang and Elaine Sanders-Bush
    Molecular Pharmacology January 2004, 65 (1) 252-256; DOI: https://doi.org/10.1124/mol.65.1.252
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    Thiochrome Enhances Acetylcholine Affinity at Muscarinic M4 Receptors: Receptor Subtype Selectivity via Cooperativity Rather than Affinity
    S. Lazareno, V. Doležal, A. Popham and N. J. M. Birdsall
    Molecular Pharmacology January 2004, 65 (1) 257-266; DOI: https://doi.org/10.1124/mol.65.1.257

Minireview

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    Efficacy as a Vector: the Relative Prevalence and Paucity of Inverse Agonism
    Terry Kenakin
    Molecular Pharmacology January 2004, 65 (1) 2-11; DOI: https://doi.org/10.1124/mol.65.1.2

Perspectives

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    More Hints on Wnts: Gene Profiling by β2-Adrenergic Receptor-Frizzled Chimeras
    Dieter Rosskopf and Karl H. Jakobs
    Molecular Pharmacology January 2004, 65 (1) 12-14; DOI: https://doi.org/10.1124/mol.65.1.12
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    Unravelling Green Tea's Mechanisms of Action: More Than Meets the Eye
    Marietta Kaszkin, Karl-Friedrich Beck, Wolfgang Eberhardt and Josef Pfeilschifter
    Molecular Pharmacology January 2004, 65 (1) 15-17; DOI: https://doi.org/10.1124/mol.65.1.15
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Molecular Pharmacology: 65 (1)
Molecular Pharmacology
Vol. 65, Issue 1
1 Jan 2004
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  • SB-431542 Is a Potent and Specific Inhibitor of Transforming Growth Factor-β Superfamily Type I Activin Receptor-Like Kinase (ALK) Receptors ALK4, ALK5, and ALK7
  • The G-Protein-Coupled Receptors in the Human Genome Form Five Main Families. Phylogenetic Analysis, Paralogon Groups, and Fingerprints
  • Pharmacological Properties of Y-27632, a Specific Inhibitor of Rho-Associated Kinases
  • Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines.
  • The Orphan Human Pregnane X Receptor Mediates the Transcriptional Activation of CYP3A4 by Rifampicin through a Distal Enhancer Module
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