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The Molecular Pharmacology of Organic Anion Transporters: from DNA to FDA?

Satish A. Eraly, Kevin T. Bush, Rosemary V. Sampogna, Vibha Bhatnagar and Sanjay K. Nigam
Molecular Pharmacology March 2004, 65 (3) 479-487; DOI: https://doi.org/10.1124/mol.65.3.479
Satish A. Eraly
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Kevin T. Bush
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Rosemary V. Sampogna
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Vibha Bhatnagar
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Sanjay K. Nigam
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Abstract

Renal organic anion secretion has been implicated in numerous clinically significant drug interactions and adverse reactions, indicating the importance of a detailed understanding of this pathway for the development of optimum therapeutics. With the cloning of multiple genes encoding organic anion transporters (OATs), the study of organic anion secretion has entered the molecular age. In this review, we focus on various aspects of the molecular biology and pharmacology of the OATs, including discussion of their structural biology, genomic organization in pairs, developmental regulation, toxicology, and pharmacogenetics. We propose functional, pathophysiological, and evolutionary hypotheses to help explain recent experimental and genomic data.

  • Received September 3, 2003.
  • Accepted October 3, 2003.
  • The American Society for Pharmacology and Experimental Therapeutics
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Molecular Pharmacology: 65 (3)
Molecular Pharmacology
Vol. 65, Issue 3
1 Mar 2004
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OtherMinireview

The Molecular Pharmacology of Organic Anion Transporters: from DNA to FDA?

Satish A. Eraly, Kevin T. Bush, Rosemary V. Sampogna, Vibha Bhatnagar and Sanjay K. Nigam
Molecular Pharmacology March 1, 2004, 65 (3) 479-487; DOI: https://doi.org/10.1124/mol.65.3.479

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The Molecular Pharmacology of Organic Anion Transporters: from DNA to FDA?

Satish A. Eraly, Kevin T. Bush, Rosemary V. Sampogna, Vibha Bhatnagar and Sanjay K. Nigam
Molecular Pharmacology March 1, 2004, 65 (3) 479-487; DOI: https://doi.org/10.1124/mol.65.3.479
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  • Article
    • Abstract
    • The Organic Anion Transporter Family of Genes
    • Structure and Function
    • Pairing and Tissue Distribution
    • Ontogeny and Morphogenesis
    • Knockouts
    • Transcriptional Regulation
    • Pharmacokinetics and Toxicology
    • Medical Anthropology and Pharmacogenetics
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