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Research ArticleArticle

Aryl Hydrocarbon Receptor Activation and Cytochrome P450 1A Induction by the Mitogen-Activated Protein Kinase Inhibitor U0126 in Hepatocytes

Lise Andrieux, Sophie Langouët, Alain Fautrel, Fréderic Ezan, Joel A. Krauser, Jean F. Savouret, F. Peter Guengerich, Georges Baffet and André Guillouzo
Molecular Pharmacology April 2004, 65 (4) 934-943; DOI: https://doi.org/10.1124/mol.65.4.934
Lise Andrieux
Institut National de la Santé et de la Recherche Médicale U620, Faculté des Sciences Pharmaceutiques et Biologiques, Université de Rennes I, Rennes, France (L.A., S.L., A.F., A.G.); Institut National de la Santé et de la Recherche Médicale U522, Hôpital Pontchaillou, Rennes, France (F.E., G.B.); Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee (J.A.K., F.P.G.); and Institut National de la Santé et de la Recherche Médicale U530, Université René Descartes, Paris, France (J.F.S.)
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Sophie Langouët
Institut National de la Santé et de la Recherche Médicale U620, Faculté des Sciences Pharmaceutiques et Biologiques, Université de Rennes I, Rennes, France (L.A., S.L., A.F., A.G.); Institut National de la Santé et de la Recherche Médicale U522, Hôpital Pontchaillou, Rennes, France (F.E., G.B.); Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee (J.A.K., F.P.G.); and Institut National de la Santé et de la Recherche Médicale U530, Université René Descartes, Paris, France (J.F.S.)
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Alain Fautrel
Institut National de la Santé et de la Recherche Médicale U620, Faculté des Sciences Pharmaceutiques et Biologiques, Université de Rennes I, Rennes, France (L.A., S.L., A.F., A.G.); Institut National de la Santé et de la Recherche Médicale U522, Hôpital Pontchaillou, Rennes, France (F.E., G.B.); Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee (J.A.K., F.P.G.); and Institut National de la Santé et de la Recherche Médicale U530, Université René Descartes, Paris, France (J.F.S.)
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Fréderic Ezan
Institut National de la Santé et de la Recherche Médicale U620, Faculté des Sciences Pharmaceutiques et Biologiques, Université de Rennes I, Rennes, France (L.A., S.L., A.F., A.G.); Institut National de la Santé et de la Recherche Médicale U522, Hôpital Pontchaillou, Rennes, France (F.E., G.B.); Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee (J.A.K., F.P.G.); and Institut National de la Santé et de la Recherche Médicale U530, Université René Descartes, Paris, France (J.F.S.)
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Joel A. Krauser
Institut National de la Santé et de la Recherche Médicale U620, Faculté des Sciences Pharmaceutiques et Biologiques, Université de Rennes I, Rennes, France (L.A., S.L., A.F., A.G.); Institut National de la Santé et de la Recherche Médicale U522, Hôpital Pontchaillou, Rennes, France (F.E., G.B.); Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee (J.A.K., F.P.G.); and Institut National de la Santé et de la Recherche Médicale U530, Université René Descartes, Paris, France (J.F.S.)
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Jean F. Savouret
Institut National de la Santé et de la Recherche Médicale U620, Faculté des Sciences Pharmaceutiques et Biologiques, Université de Rennes I, Rennes, France (L.A., S.L., A.F., A.G.); Institut National de la Santé et de la Recherche Médicale U522, Hôpital Pontchaillou, Rennes, France (F.E., G.B.); Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee (J.A.K., F.P.G.); and Institut National de la Santé et de la Recherche Médicale U530, Université René Descartes, Paris, France (J.F.S.)
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F. Peter Guengerich
Institut National de la Santé et de la Recherche Médicale U620, Faculté des Sciences Pharmaceutiques et Biologiques, Université de Rennes I, Rennes, France (L.A., S.L., A.F., A.G.); Institut National de la Santé et de la Recherche Médicale U522, Hôpital Pontchaillou, Rennes, France (F.E., G.B.); Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee (J.A.K., F.P.G.); and Institut National de la Santé et de la Recherche Médicale U530, Université René Descartes, Paris, France (J.F.S.)
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Georges Baffet
Institut National de la Santé et de la Recherche Médicale U620, Faculté des Sciences Pharmaceutiques et Biologiques, Université de Rennes I, Rennes, France (L.A., S.L., A.F., A.G.); Institut National de la Santé et de la Recherche Médicale U522, Hôpital Pontchaillou, Rennes, France (F.E., G.B.); Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee (J.A.K., F.P.G.); and Institut National de la Santé et de la Recherche Médicale U530, Université René Descartes, Paris, France (J.F.S.)
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André Guillouzo
Institut National de la Santé et de la Recherche Médicale U620, Faculté des Sciences Pharmaceutiques et Biologiques, Université de Rennes I, Rennes, France (L.A., S.L., A.F., A.G.); Institut National de la Santé et de la Recherche Médicale U522, Hôpital Pontchaillou, Rennes, France (F.E., G.B.); Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee (J.A.K., F.P.G.); and Institut National de la Santé et de la Recherche Médicale U530, Université René Descartes, Paris, France (J.F.S.)
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Article Information

vol. 65 no. 4 934-943
DOI 
https://doi.org/10.1124/mol.65.4.934
PubMed 
15044623

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received August 5, 2003
  • Accepted December 22, 2003
  • Published online March 25, 2004.

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Lise Andrieux,
  2. Sophie Langouët,
  3. Alain Fautrel,
  4. Fréderic Ezan,
  5. Joel A. Krauser,
  6. Jean F. Savouret,
  7. F. Peter Guengerich,
  8. Georges Baffet, and
  9. André Guillouzo
  1. Institut National de la Santé et de la Recherche Médicale U620, Faculté des Sciences Pharmaceutiques et Biologiques, Université de Rennes I, Rennes, France (L.A., S.L., A.F., A.G.); Institut National de la Santé et de la Recherche Médicale U522, Hôpital Pontchaillou, Rennes, France (F.E., G.B.); Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee (J.A.K., F.P.G.); and Institut National de la Santé et de la Recherche Médicale U530, Université René Descartes, Paris, France (J.F.S.)
  1. Address correspondence to:
    Dr. Sophie Langouët, INSERM U620, Université Rennes I, 2 avenue du Professeur L Bernard, 35043 RENNES Cedex, France. E-mail: sophie.langouet{at}rennes.inserm.fr
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Molecular Pharmacology: 65 (4)
Molecular Pharmacology
Vol. 65, Issue 4
1 Apr 2004
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Research ArticleArticle

Aryl Hydrocarbon Receptor Activation and Cytochrome P450 1A Induction by the Mitogen-Activated Protein Kinase Inhibitor U0126 in Hepatocytes

Lise Andrieux, Sophie Langouët, Alain Fautrel, Fréderic Ezan, Joel A. Krauser, Jean F. Savouret, F. Peter Guengerich, Georges Baffet and André Guillouzo
Molecular Pharmacology April 1, 2004, 65 (4) 934-943; DOI: https://doi.org/10.1124/mol.65.4.934

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Research ArticleArticle

Aryl Hydrocarbon Receptor Activation and Cytochrome P450 1A Induction by the Mitogen-Activated Protein Kinase Inhibitor U0126 in Hepatocytes

Lise Andrieux, Sophie Langouët, Alain Fautrel, Fréderic Ezan, Joel A. Krauser, Jean F. Savouret, F. Peter Guengerich, Georges Baffet and André Guillouzo
Molecular Pharmacology April 1, 2004, 65 (4) 934-943; DOI: https://doi.org/10.1124/mol.65.4.934
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